Abstract
The reaction of chloroacetamide with 2 equiv of γ-aminobutyric acid potassium salts provides a convenient method for the synthesis of substituted 4-[(2-amino-2-oxoethyl)amino]butanoic acids. Alkylation products of 2-aminoacetic and 3-aminopropanoic acid with chloroacetamide were isolated. Thermal cyclization of substituted 4-[(2-amino-2-oxoethyl)amino]butanoic acids afforded 2-(2-oxopyrrolidin-1-yl)acetamides.
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Original Russian Text © M.A. Kavina, V.V. Sizov, I.P. Yakovlev, 2017, published in Zhurnal Organicheskoi Khimii, 2017, Vol. 53, No. 6, pp. 857–862.
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Kavina, M.A., Sizov, V.V. & Yakovlev, I.P. Synthesis of substituted 2-(2-oxopyrrolidin-1-yl)acetamides. Russ J Org Chem 53, 873–878 (2017). https://doi.org/10.1134/S1070428017060100
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DOI: https://doi.org/10.1134/S1070428017060100