Abstract
In the present study, we report the synthesis of 5-[4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)phenyl]-1H-tetrazole derivatives by the Michael addition of chalcones to hydrazine hydrate in presence of acetic acid under conventional heating and microwave irradiation. All the synthesized compounds are characterized by IR, NMR, and mass spectra. The products are screened for their in vitro antimicrobial activity against strains such as Staphylococcus aurous, Bacillus subtilis, Klebsiella pneumonia, Escherichia coli, Aspergillus Niger, Aspergillus flavus, and Fusarium oxysporum. Most of the compounds exhibit high activity.
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Funding
The authors are thankful to The Head, Department of Chemistry, Osmania University for providing laboratory facilities and the Director, Central Facilities for Research and Development (CFRD), Osmania University for providing IR and NMR spectral analysis. We are thankful to the University Grants Commission, New Delhi, for their financial support. D. Ashok is thankful to UGC, New Delhi for the award of UGC-BSR fellowship.
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Ashok, D., Nagaraju, N., Lakshmi, B.V. et al. Microwave Assisted Synthesis of 5-[4-(3-Phenyl-4,5-dihydro-1H-pyrazol-5-yl)phenyl]-1H-tetrazole Derivatives and Their Antimicrobial Activity. Russ J Gen Chem 89, 1905–1910 (2019). https://doi.org/10.1134/S1070363219090275
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DOI: https://doi.org/10.1134/S1070363219090275