Abstract
New piperidinone incorporating pyrimidine, triazine, diazipine, oxatriazine, and thiazole derivatives have been synthesized starting with tetramethylpipridin-4-one. Structures of the newly synthesized compounds are characterized on the basis of spectroscopic and analytical data. The anticancer activity of the prepared compounds has been studied in vitro against HCT-116 and MCF-7 human cancer cells using the MTT assay. A number of compounds demonstrates potent activity towards both cell lines with IC50 values comparable with doxorubicin.
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Yousif, M.N.M., Nassar, I.F., Yousif, N.M. et al. Synthesis and Anticancer Activity of New Substituted Piperidinones Linked to Pyrimidine, Thiazole, and Triazole Glycoside Derivatives. Russ J Gen Chem 89, 1673–1682 (2019). https://doi.org/10.1134/S1070363219080218
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DOI: https://doi.org/10.1134/S1070363219080218