Abstract
A series of thieno-pyrimidine derivatives are synthesized from 5′-amino-2,3′-bithiophene-4′-carboxylate via the corresponding intermediate N-benzoylated carboxamide derivatives. The target compounds are tested for antibacterial and antifungal activity. Some of the synthesized compounds demonstrate potent antibacterial activity with LD50 comparable with the reference drug indomethacin.
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The authors are grateful to the Deanship of Scientific Research, king Saud University for funding through Vice Deanship of Scientific Research Chairs.
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El-Shehry, M.F., Hosni, H.M., Amr, A.E. et al. Synthesis of Some New Substituted Thieno[2,3-d]pyrimidine Derivatives as Antimicrobial Agents. Russ J Gen Chem 89, 1528–1534 (2019). https://doi.org/10.1134/S1070363219070247
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DOI: https://doi.org/10.1134/S1070363219070247