Abstract
Three-component reaction of acetoacetanilide, aromatic aldehydes, and N-methylurea afforded 6-aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. IR, 1H NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis data confirmed the structure of the compounds obtained. Antimicrobial activity of these compounds was investigated.
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Kappe, C.O., Eur. J. Med. Chem., 2000, vol. 35, p. 1043. DOI: DOI: 10.1016/S0223-5234(00)01189-2.
Vdovina, S.V. and Mamedov, V.A., Russ. Chem. Rev., 2008, vol. 77, no. 12, p. 1017. DOI: 10.1070/RC2008v077n12ABEH003894.
Zamanova, A.V., Kurbanova, M.M., and Farzaliev, V.M., Izv. Vuzov, Ser. Khim. i Khim. Tekhnol., 2010, vol. 53, no. 4, p. 111.
Brands, M., Endermann, R., and Gahlmann, R., Bioorg. Med. Chem. Lett., 2003, vol. 13, p. 241. DOI: 10.1016/S0960-894X(02)00880-6.
Gein, V.L., Fedotov, A.Yu., Zamaraeva, T.M., Bobyleva, A.A., Kasimova, N.N., and Odegova, T.F., Pharm. Chem. J., 2013, vol. 46, no. 12, p. 720. DOI: 10.1007/s11094-013-0877-6.
Gein, V.L., Fedotov, A.Yu., Zamaraeva, T.M., and Vakhrin, M.I., Russ. J. Gen. Chem., 2013, vol. 83, no. 4, p. 781. DOI: 10.1134/S1070363213040324.
CrysAlisPro, Agilent Technologies, Version 1.171.36.28 (release 01-02-2013 CrysAlis171.NET).
Dolomanov, O.V., Bourhis, L.J., Gildea, R.J., Howard, J.A.K., and Puschmann, M., J. Appl. Cryst., 2009, vol. 42, p. 339. DOI: 10.1107/S0021889808042726.
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Original Russian Text © T.M. Zamaraeva, T.F. Odegova, A.Yu. Fedotov, M.V. Tomilov, V.L. Gein, P.A. Slepukhin, 2014, published in Zhurnal Obshchei Khimii, 2014, Vol. 84, No. 10, pp. 1672–1675.
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Zamaraeva, T.M., Odegova, T.F., Fedotov, A.Y. et al. Synthesis and antimicrobial activity of 6-aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. Russ J Gen Chem 84, 1950–1952 (2014). https://doi.org/10.1134/S1070363214100168
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DOI: https://doi.org/10.1134/S1070363214100168