Abstract
The activity of caspase-3, caspase-8, superoxide dismutase, and catalase and the content of circulating immune complexes and immunoglobulins A, M, and G in the blood serum and muscles of rats in the norm, in experimental rheumatoid arthritis, and by the action of lipoic acid against the background of progressive pathology have been studied. The induction of rheumatoid arthritis in rats was accompanied by an increase in marker parameters and immune status indices, as well as in the activity of caspase-3, caspase-8, superoxide dismutase, and catalase, which was probably caused by excessive generation of reactive oxygen species during the development of pathology. The administration of lipoic acid to rats with rheumatoid arthritis led to a normalization of the parameters, which was evidently due to the capacity of the compound to produce the antioxidant effect and reduce the severity of autoimmune diseases.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Abbreviations
- CIC:
-
circulating immune complexes
- DHLA:
-
dihydrolipoic acid
- FRO:
-
free-radical oxidation
- LA:
-
lipoic acid
- LPO:
-
lipid peroxidation
- NBT:
-
nitro blue tetrazolium
- PMS:
-
phenazine methosulfate
- RA:
-
rheumatoid arthritis
- RF:
-
rheumatoid factor
- ROS:
-
reactive oxygen species
- SOD:
-
superoxide dismutase
- ESR:
-
erythrocyte sedimentation rate
References
Mazurov, V.I., Klinicheskaya revmatologiya: rukovodstvo dlya vrachei (Clinical Rheumatology: A Guide for Physicians), St. Petersburg: Foliant, 2005.
Hirao, M., Yamasaki, N., Oze, H., Ebina, K., Nampei, A., Kawato, Y., Shi, K., Yoshikawa, H., Nishimoto, N., and Hashimoto, J., Rheumatol. Int., 2012, vol. 32, pp. 4041–4045.
Rho, Y.H., Chung, C.P., Oeser, A., Solus, J.F., Gebretsadik, T., Shintani, A., Raggi, P., Milne, G.L., and Stein, C.M., Arthritis Care Res., 2010, vol. 62, no. 10, pp. 1473–1480.
Popova, T.N., Agarkov, A.A., and Verevkin, A.N., Acta Naturae, 2013, vol. 5, no. 4 (19), pp. 129–134.
Tchetina, E.V., Demidova, N.V., Karateev, D.E., and Nasonov, E.L., Int. J. Rheumatol., 2013, vol. 2013, Article ID457876.
Martinova, E.A., Russ. J. Bioorg. Chem., 2003, vol. 29, no. 5, pp. 471–495.
Tien, Y.C., Liao, J.C., Chiu, C.S., Huang, T.H., Huang, C.Y., Chang, W.T., and Peng, W.H., Int. J. Mol. Sci., 2011, vol. 1, no. 2, pp. 4053–4067.
Bayati, S. and Yazdanparast, R., Iranian Biomed. J., 2011, vol. 15, no. 4, pp. 134–142.
Liang, H.L., Arsenault, J., Mortensen, J., Park, F., Johnson, C.P., and Nilakantan, V., Apoptosis, 2009, vol. 14, no.10.
Swaran, J.S., Flora, Oxid. Med. Cell. Longev., 2009, vol. 2, no. 4, pp. 191–206.
Liang, J.F., Chem. Biol. Interact., 2000, vol. 124, no. 1, pp. 53–60.
Zacharias, E., Pharm. Res., 2003, no. 48, pp. 585–591.
Gomes, M.B. and Negrato, C.A., Diabetol. Metab. Syndr., 2014, vol. 6, no.80.
Mesquitaa, A., Weinbergerb, M., Silvaa, A., Sampaio-Marquesa, B., Almeidaa, B., Leaoa, C., Costa, V., Rodriguesa, F., Burhans, W.C., and Ludovico, P., Proc. Natl. Acad. Sci. U. S. A., 2010, vol. 107, no. 34, pp. 15123–15128.
Holers, V.M., Curr. Opin. Immunol., 2013, vol. 25, no. 6, pp. 728–735.
Van Steendam, K., Tilleman, K., De Ceuleneer, M., De Keyser, F., Elewaut, D., and Deforce, D., Arthritis Res. Ther., 2010, vol. 12, no. R132.
Salintho, S., Yadav, V., Schillace, R.V., Bourdette, D.N., and Carr, D.W., PLoS ONE, 2010, vol. 5, no.9.
Yadav, V., Marracci, G.H., Munar, M.Y., Cherala, G., Stuber, L.E., Alvarez, L., Shinto, L., Koop, D.R., and Bourdette, D.N., Mult. Scler., 2010, vol. 16, no. 4, pp. 387–397.
Deneke, S.M., Curr. Top. Cell Regul., 2000, vol. 36, pp. 151–180.
Self, W.T., Tsai, L., and Stadtman, T.C., Proc. Natl. Acad. Sci. U. S. A., 2000, vol. 97, pp. 12481–12486.
Pierce, R.H., Campbell, J.S., Stephenson, A.B., Franklin, C.C., Chaisson, M., Poot, M., Kavanagh, T.J., Rabinovitch, P.S., and Fausto, N., Am. J. Pathol., 2000, vol. 157, no. 1, pp. 221–236.
Kaya-Dagistanli, F., Tanriverdi, G., Altinok, A., Ozyazgan, S., and Ozturk, M., Food Chem. Toxicol., 2013, vol. 53, pp. 84–93.
Bobyrev, V.N., Pochernyaeea, V.F., Starodubtsev, S.G., Bobyreva, L.E., Dubinskaya, G.M., and Voskresenskii, O.N., Eksp. Klin. Farmakol., 1994, vol. 57, no. 1, pp. 47–54.
Filippin, L.I., Vercelino, R., Marroni, N.P., and Xavier, R.M., Clin. Exp. Immunol., 2008, vol. 152, pp. 415–422.
Frei, B., Stocker, R., and Ames, B., Proc. Natl. Acad. Sci. U. S. A., 1988, vol. 85, pp. 9748–9752.
Feng, B., Yan, X.F., Xue, J.L., Xu, L., and Wang, H., Int. J. Mol. Sci., 2013, vol. 14, no. 4, pp. 6746–6756.
Vershinin, V.I., Vlasova, I.V., and Nikiforova, I.A., Analiticheskaya khimiya (Analytical Chemistry), Moscow: Akademiya, 2011.
Lugovskaya, S.A., Morozova, V.T., Pochtar’, M.E., and Dolgov, V.V., Laboratornaya gematologiya (Laboratory Hematology), Tver: Triada, 2014.
White, A., Handler, P., Smith, E., Hill, R., and Lehman, I.R., Principles of Biochemistry, New York: McGrow-Hill, 1978.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © E.D. Kryl’skiy, T.N. Popova, E.M. Kirilova, O.A. Safonova, 2016, published in Bioorganicheskaya Khimiya, 2016, Vol. 42, No. 4, pp. 431–439.
Rights and permissions
About this article
Cite this article
Kryl’skiy, E.D., Popova, T.N., Kirilova, E.M. et al. Effect of lipoic acid on the activity of caspases and the characteristics of the immune and antioxidant statuses in rats with rheumatoid arthritis. Russ J Bioorg Chem 42, 389–396 (2016). https://doi.org/10.1134/S1068162016040130
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1068162016040130