Abstract
A new highly sensitive and rapid approach to the determination of 1,1-dimethylhydrazine in natural water is developed (determination range is 0.03–1 μg/L). It is based on the use of high-performance liquid chromatography–tandem mass spectrometry with precolumn derivatization by phenylglyoxal and does not require any preconcentration. Derivatization, chromatographic separation conditions, and tandem mass spectrometry detection parameters are chosen. Intra-day precision of the results of measurements of 1,1- dimethylhydrazine in natural water is 12–16%, and inter-day precision is 16–22%. The lowest limit of detection and the lowest limit of quantification are 0.010 μg/L and 0.030 μg/L, respectively.
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Original Russian Text © S.V. Osipenko, R.S. Smirnov, A.D. Smolenkov, O.A. Shpigun, 2015, published in Mass-spektrometriya, 2015, Vol. 12, No. 4, pp. 247–252.
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Osipenko, S.V., Smirnov, R.S., Smolenkov, A.D. et al. Highly sensitive determination of 1,1-dimethylhydrazine by high-performance liquid chromatography–tandem mass spectrometry with precolumn derivatization by phenylglyoxal. J Anal Chem 71, 1228–1232 (2016). https://doi.org/10.1134/S1061934816130098
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DOI: https://doi.org/10.1134/S1061934816130098