Abstract
Methods are proposed for the identification and determination of residual quantities of antibiotics from various classes in food- and feedstuffs for animals by matrix-or surface-assisted laser desorption/ionization mass spectrometry (MALDI/SALDI MS). It is shown that acetonitrile is efficient for the extraction of antibiotics without additional extract purification. The limits of detection for antibiotics in the indicated products are 0.01–0.3 μg/kg in MALDI MS and 0.001–0.03 μg/kg in SALDI MS at the signal-to-noise ratio 4. The relative standard deviation of the results of determination of antibiotics does not exceed 10% in feedstuffs and premixes at the analytical range 20–400 mg/kg for monensin and narasin, 0.2–200 mg/kg for tilmicosin, and 20–1000 mg/kg for avilamycin and a weighed portion of feedstuff 1.0 g. The time of analysis is 40–50 min.
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Original Russian Text © V.G. Amelin, T.A. Krasnova, 2015, published in Zhurnal Analiticheskoi Khimii, 2015, Vol. 70, No. 7, pp. 734–744.
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Amelin, V.G., Krasnova, T.A. Identification and determination of antibiotics from various classes in food- and feedstuffs by matrix-or surface-assisted laser desorption/ionization mass spectrometry. J Anal Chem 70, 850–859 (2015). https://doi.org/10.1134/S1061934815070023
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DOI: https://doi.org/10.1134/S1061934815070023