Abstract
Initially our method of the decomposition of charge state distributions of biopolymer ions was designed to estimate the probabilities of the retention of charges by biopolymer ionogenic groups without distinction of different charge carriers (proton, alkali metal ions, or other ions). The analysis of mass spectra of several peptides and proteins produced by electrospray ionization carried out on this basis made possible some conclusions about their ion structure and behavior inside the ion source. A generalization of the method for the case of multidimensional charge state distributions corresponding to the retention of various charge carriers by ions of biomolecules is described. Hopefully, this will make possible gaining more substantial information concerning the structure and behavior of biomolecule ions in solutions and under electrospray conditions, which can be important for various biological applications.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Fenn, J.B., Mann, M., Meng, C.K., Wong, S.F., and Whitehouse, C.M., Science, 1989, vol. 246, no. 4929, p. 464.
Aleksandrov, M.L., Gall’, L.N., Krasnov, N.V., Nikolaev, V.I., Pavlenko, V.A., and Shkurov, V.A, Dokl. Akad. Nauk SSSR, 1984, vol. 277, no. 2, p. 379.
Ferrige, A.G., Seddon, M.J., Green, B.N., Jarvis, S.A., and Skilling, J., Rapid Commun. Mass Spectrom., 1992, vol. 6, no. 7, p. 707.
Abzalimov, R.R., Fringpong, A.K., and Kaltashov, I.A., Int. J. Mass Spectrom., 2006, vol. 253, no. 3, p. 207.
Hogan, C.J., Carroll, J.A., Rohrs, H.W., Biswas, P., and Gross, M.L., J. Am. Chem. Soc., 2008, vol. 130, no. 12, p. 6926.
Kaltashov, I.A. and Mohimen, A., Anal. Chem., 2005, vol. 77, no. 16, p. 5370.
Mohimen, A., Dobo, A., Hoerner, J.K., and Kaltashov, I.A., Anal. Chem., 2003, vol. 75, no. 16, p. 4139.
Raznikov, V.V. and Raznikova, M.O., Which Information Can Be Acquired from the Distribution of Multicharged Ions Produced by Electrospray-Induced Fragmentation of Bioorganic Compounds?, 4 Vseross. konf. Mass-spektrometriya i ee prikladnye problemi (4th All-Russia Conf. Mass-Spectrometry and Applied Problems), Moscow, 2011.
Felitsyn, N., Peschke, M., and Kebarle, P., Int. J. Mass Spectrom., 2002, vol. 219, no. 1, p. 39.
Dole, M., Mack, L.L., Hines, R.L., Mobley, R.S., Feruson, L.D., and Alice, M.B., J. Chem. Phys., 1968, vol. 49, no. 5, p. 2240.
Verkerk, U.H. and Kebarle, P., J. Am. Soc. Mass Spectrom., 2005, vol. 16, no. 8, p. 1325.
Raznikov, V.V. and Raznikova, M.O., Eur. J. Mass Spectrom., 2009, vol. 15, no. 3, p. 367.
Korolyuk, V.S., Portenko, N.I., Skorokhod, A.V., and Turbin, A.F., Spravochnik po teorii veroyatnostei i matematicheskoi statistike (Handbook on the Probability Theory and Mathematical Statistics), Moscow: Nauka, 1985.
Yergey, J.A., Int. J. Mass Spectrom. Ion Phys., 1983, vol. 52, nos. 2–3, p. 337.
Orlov, A.I., Prikladnaya statistika (Applied Statistics), Moscow: Ekzamen, 2004.
Raznikov, V.V., Pikhtelev, A.R., and Raznikova, M.O., Mass-Spektrometria, 2006, vol. 3, no. 2, p. 113.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © V.V. Raznikov, M.O. Raznikova, 2013, published in Mass-spektrometria, 2013, Vol. 10, No. 3, pp. 175–181.
Rights and permissions
About this article
Cite this article
Raznikov, V.V., Raznikova, M.O. Decomposition of multidimensional charge state distributions of ions produced by electrospray ionization of bioorganic compounds. Part 1: Basic formalism and implementation of the method. J Anal Chem 69, 1270–1277 (2014). https://doi.org/10.1134/S1061934814130073
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1061934814130073