Abstract
Fabrication of electrospun chitosan nanofibers is still a controversial issue in publications. Although regarding the lots of reports, mixtures of chitosan with a hydrophilic synthetic polymer such as polyethylene oxide (PEO) have been electrospun successfully, abundance of partly contradictory protocols in which one variable has been surveyed in each study is unfortunately baffling. In the present study, influence of three considerable parameters including the average molecular weight of chitosan, chitosan solution concentration and the mass ratio of polyethylene oxide to chitosan at the mixtures on electrospinning possibility as well as the quality of as-spun fibers is investigated. Eventually, the necessities for obtaining the best results are introduced followed by further analysis of optimized nanofibers using atomic force microscopy. According to our results, the blend solutions prepared from the low molecular weight (LMW) chitosan and PEO are efficient for reproducible production of bead-free electrospun nanofibers even in low proportion of polyethylene oxide.
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References
D. Liang, B. S. Hsiao, and B. Chu, Adv. Drug Delivery Rev. 59, 1392 (2007).
Z.-M. Huang, Y.-Z. Zhang, M. Kotaki, and S. Ramakrishna, Compos. Sci. Technol. 63, 2223 (2003).
M. Rinaudo, Prog. Polym. Sci. 31, 603 (2006).
R. Muzzarelli and C. Muzzarelli, “Chitosan Chemistry: Relevance to the Biomedical Sciences,” in Polysaccharides I. Structure, Characterization and Use, Ed. by T. Heinze (Springer-Verlag, Berlin; Heidelberg, 2005), p. 151.
I.-Y. Kim, S.-J. Seo, H.-S. Moon, M.-K. Yoo, I.-Y. Park, B.-C. Kim, and C.-S. Cho, Biotechnol. Adv. 26, 1 (2008).
H. Park, B. Choi, J. Hu, and M. Lee, Acta Biomater. 9, 4779 (2013).
F. Croisier and C. Jérôme, Eur. Polym. J. 49, 780 (2013).
M. Karimi, P. Avci, R. Mobasseri, M. R. Hamblin, and H. Naderi-Manesh, J. Nanopart. Res. 15, 1 (2013).
M. Karimi, P. Avci, M. Ahi, T. Gazori, M. R. Hamblin, and H. Naderi-Manesh, J. Nanopharm. Drug Delivery 1, 266 (2013).
S. A. Agnihotri, N. N. Mallikarjuna, and T. M. Aminabhavi, J. Controlled Release 100, 5 (2004).
N. Bhattarai, J. Gunn, and M. Zhang, Adv. Drug Delivery Rev. 62, 83 (2010).
K. Pospiskova and I. Safarik, Carbohydr. Polym. 96, 545 (2013).
S. Datta, L. R. Christena, and Y. R. S. Rajaram, Biotechnology 3, 1 (2013).
J. Wang and C. Chen, Bioresour. Technol. 160, 129 (2014).
J. Wang, W. Xu, L. Chen, X. Huang, and J. Liu, Chem. Eng. J. 251, 25 (2014).
M. Aliabadi, M. Irani, J. Ismaeili, H. Piri, and M. J. Parnian, Chem. Eng. J. 220, 237 (2013).
K. Sunand and Z. Li, eXPRESS Polym. Lett. 5, 342 (2011).
K. Ziani, C. Henrist, C. Jérôme, A. Aqil, J. I. Maté, and R. Cloots, Carbohydr. Polym. 83, 470 (2011).
K. Ohkawa, D. Cha, H. Kim, A. Nishida, and H. Yamamoto, Macromol. Rapid Commun. 25, 1600 (2004).
H. Homayoni, S. A. H. Ravandi, and M. Valizadeh, Carbohydr. Polym. 77. 656 (2009).
P. Sangsanoh and P. Supaphol, Biomacromolecules 7, 2710 (2006).
N. Bhattarai, D. Edmondson, O. Veiseh, F. A. Matsen, and M. Zhang, Biomaterials 26, 6176 (2005).
M. Pakravan, M.-C. Heuzey, and A. Ajji, Polymer 52, 4813 (2011).
B. Duan, C. Dong, X. Yuan, and K. Yao, J. Biomater. Sci., Polym. Ed. 15, 797 (2004).
M. Spasova, N. Manolova, D. Paneva, and I. Rashkov, e-Polym. 4, 624 (2004).
Y.-T. Jia, J. Gong, X.-H. Gu, H.-Y. Kim, J. Dong, and X.-Y. Shen, Carbohydr. Polym. 67, 403 (2007).
N. Charernsriwilaiwat, T. Rojanarata, T. Ngawhirunpat, and P. Opanasopit, Int. Wound J. 11, 215 (2014).
A. Cooper, N. Bhattarai, F. M. Kievit, M. Rossol, and M. Zhang, Phys. Chem. Chem. Phys. 13, 9969 (2011).
Q. Li, X. Wang, X. Lou, H. Yuan, H. Tu, B. Li, and Y. Zhang, Carbohydr. Polym. 130, 166 (2015).
J. D. Schiffman and C. L. Schauer, Biomacromolecules 8, 594 (2007).
Zainuddin, J. Albinska, P. Ulanski, and J. Rosiak, J. Radioanal. Nucl. Chem. 253, 339 (2002).
M. Doytcheva, D. Dotcheva, R. Stamenova, A. Orahovats, C. Tsvetanov, and J. Leder, J. Appl. Polym. Sci. 64, 2299 (1997).
E. Mirzaei, R. Faridi-Majidi, M. A. Shokrgozar, and F. Asghari Paskiabi, Nanomed. J. 1, 137 (2014).
Y.-Y. Wang, L.-X. Lü, Z.-Q. Feng, Z.-D. Xiao, and N.-P. Huang, Biomed. Mater. 5, 054112 (2010).
R. A. Muzzarelli, Mar. Drugs 9, 1510 (2011).
C. Kriegel, K. Kit, D. J. McClements, and J. Weiss, Polymer 50, 189 (2009).
R. R. Klossner, H. A. Queen, A. J. Coughlin, and W. E. Krause, Biomacromolecules 9, 2947 (2008).
J.-F. Zhang, D.-Z. Yang, F. Xu, Z.-P. Zhang, R.-X. Yin, and J. Nie, Macromolecules 42, 5278 (2009).
K. Desai, K. Kit, J. Li, and S. Zivanovic, Biomacromolecules 9, 1000 (2008).
X. Geng, O.-H. Kwon, and J. Jang, Biomaterials 26, 5427 (2005).
L. Martinova and D. Lubasova, Res. J. Text. Apparel 12, 72 (2008).
P. Sorlier, C. Viton, and A. Domard, Biomacromolecules 3, 1336 (2002).
J. Roussy, M. Van Vooren, and E. Guibal, J. Appl. Polym. Sci. 98, 2070 (2005).
C. Pillai and C. P. Sharma, Trends Biomater. Artif. Organs 22, 179 (2009).
C. Pillai, W. Paul, and C. P. Sharma, Prog. Polym. Sci. 34, 641 (2009).
G. Macfie, R. G. Compton, and H. R. Corti, J. Chem. Eng. Data 46, 1300 (2001).
K. Ohkawa, K.-I. Minato, G. Kumagai, S. Hayashi, and H. Yamamoto, Biomacromolecules 7, 3291 (2006).
H. Homayoni, S. A. H. Ravandi, and M. Valizadeh, J. Appl. Polym. Sci. 113, 2507 (2009).
R. P. Gonçalves, W. H. Ferreira, R. F. Gouvêa, and C. T. Andrade, Mater. Res. 20, 984 (2017).
J. Grobelny, F. W. DelRio, N. Pradeep, D.-I. Kim, V. A. Hackley, and R. F. Cook, “Size Measurement of Nanoparticles using Atomic Force Microscopy,” in Characterization of Nanoparticles Intended for Drug Delivery, Ed. by S. E. McNeil (Springer, New York, 2011), p. 71.
P. Markiewicz and M. C. Goh, J. Vac. Sci. Technol., B: Microelectron. Nanometer Struct.—Process., Meas., Phenom. 13, 1115 (1995).
J. Širc, R. Hobzová, N. Kostina, M. Munzarová, M. Juklickova, M. Lhotka, S. Kubinova, A. Zajicova, and J. Michalek, J. Nanomater. 2012, 121 (2012).
D. Reneker, W. Kataphinan, A. Theron, E. Zussman, and A. Yarin, Polymer 43, 6785 (2002).
A. K. Aljehani, M. A. Hussaini, M. A. Hussain, N. S. Alothmany, and R. W. Aldhaheri, in Proceedings of “IEEE Middle East Conference on Biomedical Engineering (MECBME),” Doha, Qatar, 2014 (Doha, 2014), p. 379.
C. Xu, F. Yang, S. Wang, and S. Ramakrishna, J. Biomed. Mater. Res., Part A 71, 154 (2004).
T. P. Kunzler, T. Drobek, M. Schuler, and N. D. Spencer, Biomaterials 28, 2175 (2007).
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Sohi, A.N., Naderi-Manesh, H., Soleimani, M. et al. Influence of Chitosan Molecular Weight and Poly(ethylene oxide): Chitosan Proportion on Fabrication of Chitosan Based Electrospun Nanofibers. Polym. Sci. Ser. A 60, 471–482 (2018). https://doi.org/10.1134/S0965545X18040077
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DOI: https://doi.org/10.1134/S0965545X18040077