Abstract
This review summarizes the literature data as well as experimental results obtained at our Institute over a period of 50 years on the substrate specificity of cholinesterases–acetylcholine acetylhydrolases (EC 3.1.1.7) and acylcholine acylhydrolases (EC 3.1.1.8). The parameters of enzymatic hydrolysis of oxo- and thiocholine and β-methylcholine esters in different organs and tissues were analyzed in 66 animal species including 22 chordate, 20 insect, 1 mite, 17 mollusk, 4 nematode, and 2 flatworm species. Our substrate specificity studies and extensive data on the inhibitory specificity obtained using irreversible organophosphorous inhibitors and reversible effectors unequivocally indicate that the cholinesterase family is characterized by a clear-cut species and tissue specificity.
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Original Russian Text © N.E. Basova, B.N. Kormilitsyn, A.Yu. Perchenok, E.V. Rozengart, V.S. Saakov, A.A. Suvorov, 2018, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2018, Vol. 54, No. 3, pp. 141–153.
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Basova, N.E., Kormilitsyn, B.N., Perchenok, A.Y. et al. Substrate Specificity of Cholinesterases in Various Representatives of the Animal Kingdom. J Evol Biochem Phys 54, 157–174 (2018). https://doi.org/10.1134/S0022093018030018
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DOI: https://doi.org/10.1134/S0022093018030018