Abstract
A significant antitumor activity of aqueous solutions of binuclear dinitrosyl iron complexes with glutathione was found when they were injected intravenously in a model of a solid malignant tumor, that is, Lewis carcinoma, in mice. Dinitrosyl iron complexes completely inhibited the tumor growth (by 100%) at doses of 20, 10, and 2 μmol/kg in the first 11 days after the beginning of experiment followed by tumor proliferation at a rate that was lowest for the lowest of the used doses. At day 16, the inhibition of tumor growth was 90% when a solution of dinitrosyl iron complexes was injected at a dose of 2 μmol/kg five times with an interval of 2 to 3 days between injections; whereas the inhibition of tumor growth did not exceed 70 and 30% at doses of 10 and 20 μmol/kg, respectively. Acceleration, rather than inhibition of carcinoma growth was observed at a dose of 100 μmol/kg. The tumor weight increased 1.5–2.0 times compared to the control values, depending on the time.
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Abbreviations
- B-DNIC−GS:
-
binuclear dinitrosyl iron complex with glutathione
- M-DNIC:
-
mononuclear dinitrosyl iron complex
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Original Russian Text © A.F. Vanin, L.A. Ostrovskaya, D.B. Korman, V.A. Rykova, N.V. Blyuchterova, M.M. Fomina, 2017, published in Biofizika, 2017, Vol. 62, No. 3, pp. 591–597.
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Vanin, A.F., Ostrovskaya, L.A., Korman, D.B. et al. The antitumor effect of dinitrosyl iron complexes with glutathione in a murine solid-tumor model. BIOPHYSICS 62, 479–484 (2017). https://doi.org/10.1134/S000635091703023X
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DOI: https://doi.org/10.1134/S000635091703023X