Abstract
For many years, investigators have attempted to identify unique ultrastructural conditions of mitochondria related to aging. However, this did not result in definitive results. At present, this issue has again become of topical interest due to development of the mitochondrial theory of aging and of engineering of a novel antioxidant class known as mitochondria-targeted antioxidants. The review briefly discusses experimental results that, from our perspective, allow the most objective understanding regarding age-related changes in mitochondrial ultrastructure.
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Policard, A., and Bessis, M. (1968) Elements de Pathologie Cellulaire, MASSON et Cie, Paris.
Martin, L., Feldman, M. L., and Navaratnam, V. (1981. Ultrastructural changes in atrial myocardium of the ageing rat, J. Anat., 133, 7–17.
Beregi, E., Regius, O., Huttl, T., and Gobl, Z. (1988. Agerelated changes in the skeletal muscle cells, Z. Gerontol., 21, 83–86.
Brunk, U. T., and Terman, A. (2002. The mitochondriallysosomal axis theory of aging, Eur. J. Biochem., 269, 19962002.
Bakarev, M. A., and Nepomnyashchikh, L. M. (2004. Structural manifestations of disturbed mitochondrial function in skeletal muscle of prematurely aging rat strain OXYS, Bull. Exp. Biol. Med., 138, 674–679.
Feher, J., Kovacs, I., Artico, M., Cavallotti, C., Papale, A., and Gabrieli, C. B. (2006. Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration, Neurobiol. Aging, 27, 983–993.
Corsetti, G., Pasini, E., D’ Antona, G., Nisoli, E., Flati, V., Assanelli, D., Dioguardi, F. S., and Bianchi, R. (2008. Morphometric changes induced by amino acid supplementation in skeletal and cardiac muscles of old mice, Am. J. Cardiol., 101, 26–34.
Sachs, H., Colgan, J., and Lazarus, M. L. (1977. Ultrastructure of the aging myocardium: a morphometric approach, Am. J. Anat., 150, 63–71.
Cheng, Z., Ito, S., Nishio, N., Thanasegaran, S., Fang, H., and Isobe, K. (2013. Characteristics of cardiac aging in C57BL/6, Exp. Gerontol., 48, 341–348.
Crane, J. D., Devries, C., Safdar, A., Hamadeh, M. J., and Tarnopolsky, M. A. (2010. The effect of aging on human skeletal muscle mitochondrial and intramyocellular lipid ultrastructure, J. Gerontol., 65, 119–128.
Orlander, J., Kiessling, K., Larsson, L., Karlsson, J., and Aniansson, A. (1978. Skeletal muscle metabolism and ultrastructure in relation to age in sedentary men, Acta Physiol. Scand., 104, 249–261.
Tomanek, R., and Karlsson, U. L. (1973. Myocardial ultrastructure of young and senescent rats, J. Ultrastruct. Res., 42, 201–220.
Riva, A., Tandler, B., Lesnefsky, E., Conti, G., Loffredo, F., Vazquez, E., and Hoppel, C. (2006. Structure of cristae in cardiac mitochondria of aged rat, Mech. Ageing Dev., 127, 917–921.
Williams, C. M., Barness, L. A., and Sawyer, W. H. (1943. The utilization of glycogen by flies during flight and some aspects of the physiological ageing of Drosophila, Biol. Bull. (Woods Hole), 84, 263–268.
Sacktor, B., and Shimada, Y. (1972. Degenerative changes in the mitochondria of flight muscle from aging blowflies, J. Cell Biol., 52, 465–477.
Bakeeva, L. E., Saprunova, V. B., Pasyukova, E. G., and Roshchina, N. V. (2007. Mitoptosis in flight muscle of Drosophila melanogaster, Dokl. Akad. Nauk, 413, 1–3.
Skulachev, V. P. (2009. Functions of mitochondria: from intracellular power stations to mediators of a senescence program, Cell. Mol. Life Sci., 66, 1785–1793.
Walker, D. W., and Benzer, S. (2004. Mitochondrial “swirls” induced by oxygen stress and in the Drosophila mutant hyperswirl, Proc. Natl. Acad. Sci. USA, 101, 1029010295.
Skulachev, V. P. (2007. A biochemical approach to the problem of aging: “megaproject” on membrane-penetrating ions. The first results and prospects, Biochemistry (Moscow), 72, 1385–1396.
Antonenko, Yu. N., Avetisyan, A. V., Bakeeva, L. E., Chernyak, B. V., Chertkov, V. A., Domnina, L. V., Ivanova, O. Yu., Izyumov, D. S., Khaylova, L. S., Klishin, S. S., Korshunova, G. A., Lyamzaev, K. G., Muntyan, M. S., Nepryakhina, O. K., Pashkovskaya, A. A., Pletyushkina, O. Yu., Pustovidko, A. V., Roginskiy, V. A., Rokitskaya, T. I., Ruuge, E. K., Saprunova, V. B., Severina, I. I., Simonyan, R. A., Skulachev, I. V., Skulachev, M. V., Sumbatyan, N. V., Sviryaeva, I. V., Tashlitskiy, V. N., Vasil’ev, Yu. M., Vysokikh, M. Yu., Yaguzhinskiy, L. S., Zamyatnin, A. A., and Skulachev, V. P. (2008. Mitochondria-targeted plasto-quinone derivative as a means for disrupting aging program. 1. Cationic derivatives of plastoquinone: synthesis and in vitro examination, Biochemistry (Moscow), 73, 1273–1287.
Anisimov, V. N., Bakeeva, L. E., Egormin, P. A., Filenko, O. F., Isakova, E. F., Manskikh, V. N., Mikhel’son, V. M., Panteleeva, A. A., Pasyukova, E. G., Pilipenko, D. I., Piskunova, T. S., Popovich, I. G., Roshchina, N. V., Rybina, O. Yu., Saprunova, V. B., Samoylova, T. A., Semenchenko, A. V., Skulachev, M. V., Spivak, I. M., Tsybul’ko, E. A., Tyndyk, M. L., Vysokikh, M. Yu., Yurova, M. N., Zabezhinskiy, M. A., and Skulachev, V. P. (2008. Mitochondria-targeted plastoquinone derivative as a means for disrupting aging program. 5. SkQ1 increases lifespan and prevents developing signs of aging, Biochemistry (Moscow), 73, 1329–1342.
Skulachev, V. P., Anisimov, V. N., Antonenko, Y. N., Bakeeva, L. E., Chernyak, B. V., Erichev, V. P., Filenko, O. F., Kalinina, N. I., Kapelko, V. I., Kolosova, N. G., Kopnin, B. P., Korshunova, G. A., Lichinitser, M. R., Obukhova, L. A., Pasyukova, E. G., Pisarenko, O. I., Roginsky, V. A., Ruuge, E. K., Senin, I. I., Severina, I. I., Skulachev, M. V., Spivak, I. M., Tashlitsky, V. N., Tkachuk, V. A., Vyssokikh, M. Y., Yaguzhinsky, L. S., and Zorov, D. B. (2009. An attempt to prevent senescence: a mitochondrial approach, Biochim. Biophys. Acta, 1787, 437–461.
Bakeeva, L. E., Barskov, I. V., Egorov, M. V., Isaev, N. K., Kapel’ko, V. I., Kazachenko, A. V., Kirpatovskiy, V. I., Kozlovskiy, S. V., Lakomkin, V. L., Levina, S. V., Pisarenko, O. I., Plotnikov, E. Yu., Saprunova, V. B., Serebryakova, L. I., Skulachev, M. V., Stelmashook, E. V., Studneva, I. M., Tskitishvili, O. V., Vasil’eva, A. K., Viktorov, I. V., Zorov, D. B., and Skulachev, V. P. (2008. Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROSand age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke), Biochemistry (Moscow), 73, 1288–1299.
Shabalina, I. G., Kolosova, N. G., Grishanova, A. Yu., Solovyov, V. N., Salganik, R. I., and Solovyova, N. A. (1995. Oxidative phosphorylation activity, F0F1-ATPase, and cytochrome content in liver mitochondria of rats with inherited hyperproduction of free radicals, Biochemistry (Moscow), 66, 1563–1568.
Bakeeva, L. E., Vays, V. B., and Vangeli, I. M. (2014. Agerelated changes in mitochondrial ultrastructure of muscular tissue, Biochemistry (Moscow). Suppl. Ser A: Membr. Cell Biol., 8, 16–22.
Kolosova, N. G., Lebedev, P. A., Fursova, A. Zh., Moroskova, T. S., and Gusarevich, O. G. (2003. Prematurely aging OXYS rat strain as a model of human senile cataract, Usp. Gerontol., 12, 143–148.
Vays, V. B., Eldarov, C. M., Kolosova, N. G., and Bakeeva, L. E. (2014. Antioxidant SkQ1 delays sarcopenia-associated damage of mitochondrial ultrastructure, Aging, 6, 140–148.
Saprunova, V. B., Pilipenko, D. I., Alekseevskiy, A. V., Fursova, A. Zh., Kolosova, N. G., and Bakeeva, L. E. (2010. Lipofuscin granule dynamics during development of age-related macular degeneration, Biochemistry (Moscow), 75, 130–138.
Vays, V. B., Vangeli, I. M., and Bakeeva, L. E. (2014. Ultrastructural changes in lacrimal gland of Wistar rats upon aging, Bull. Exp. Biol. Med., 157, 235–240.
Bourgeois, J. M., and Tarnopolsky, M. A. (2004. Pathology of skeletal muscle in mitochondrial disorders, Mitochondrion, 4, 441–452.
Feldman, M. L., and Navaratnam, V. (1981. Ultrastructural changes in atrial myocardium of the ageing rat, J. Anat., 133, 7–17.
Hubner, G., and Grantzow, R. (1983. Mitochondrial cardiomyopathy with involvement of skeletal muscles, Virch. Arch. Pathol. Anat., 399, 115–125.
James, T. N., Terasaki, F., Pavlovich, E. R., and Vikhert, A. N. (1993. Apoptosis and pleomorphic micromitochondriosis in the sinus nodes surgically excised from five patients with the long QT syndrome, J. Lab. Clin. Med., 122, 309–323.
Klembovskiy, A. I., and Sukhorukov, V. S. (1997. Mitochondrial insufficiency in children, Arch. Patol., 59, 3–7.
Klembovskiy, A. I. (2008. A role for mitochondrial disorders in developing diseases. Therapeutic approaches, Vrach, 5, 21–25.
Beregi, E., Regius, O., Hutti, T., and Gobl, Z. (1988. Agerelated changes in the skeletal muscle cells, Z. Gerontol., 21, 83–86.
Yasuda, K., Ishii, T., Suda, H., Akatsuka, A., Hartman, P. S., Goto, S., Miyazawa, M., and Ishii, N. (2006. Age-related changes of mitochondrial structure and function in Caenorhabditis elegans, Mech. Ageing Dev., 127, 763–770.
Kawashima, M., Kawakita, T., Okada, N., Ogawa, Y., Murat, D., Nakamura, S., Nakashima, H., Shimmura, S., Shimmura, K., and Tsubota, K. (2010. Calorie restriction: a new therapeutic intervention for age related dry eye disease in rats, Biochem. Biophys. Res. Commun., 397, 724–728.
Kawashima, M., and Tsubota, K. (2011. Effect of calorie restriction on change in lacrimal gland with age, Cornea, 30, 29–33.
Feher, J., Kovaks, I., Artico, M., Cavallotti, C., Papale, A., and Gabrieli, C. B. (2006. Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration, Neurobiol. Aging, 27, 983–993.
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Original Russian Text © L. E. Bakeeva, 2015, published in Biokhimiya, 2015, Vol. 80, No. 12, pp. 1843-1850.
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Bakeeva, L.E. Age-related changes in ultrastructure of mitochondria. Effect of SkQ1. Biochemistry Moscow 80, 1582–1588 (2015). https://doi.org/10.1134/S0006297915120068
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DOI: https://doi.org/10.1134/S0006297915120068