Abstract
The research on the structure and role of bacterial cytochromes P450 are summarized in this review. We consider the organizational features of these enzymes, cytochrome-catalyzed reactions, the distribution of cytochromes among prokaryotes, and their functions in bacterial cells. We cite the data on cytochrome genes and the regulation of their expression in prokaryotes and classify cytochromes by components involved in the electronic transition. We consider the role of bacterial cytochromes in the biodegradation of carbohydrates and xenobiotics by microorganisms and the possible involvement of reactive oxygen species, which are generated in the catalytic cycle of these enzymes, at the initial stages of carbohydrate biodegradation.
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References
Lewis, D.F.V. and Wiseman, A., Enzyme Microb. Technol., 2005, vol. 36, pp. 377–384.
Hannemann, F., Bichet, A., Ewen, K.M., and Bernhardt, R., Biochim. Biophys. Acta, 2007, vol. 1770, no. 3, pp. 330–344.
Kubota, M., Nodate, M., Yasumoto-Hirose, M., Uchiyama, T., Kagami, O., Shizuri, Y., and Misawa, N., Biosci. Biotechnol. Biochem., 2005, vol. 69, no. 12, pp. 2421–2430.
Archakov, A.I., Mikrosomal’noe okislenie (Microsomal Oxidation), Moscow Nauka, 1975.
Montellano, P.R. and Voss, J.J., in Cytochrome P450: Structure, Mechanism, and Biochemistry, 3rd ed., Ortiz De Montellano, P.R., Ed., New York: Plenum Publishers, 2005, pp. 183–245.
Narhi, L.O. and Fulco, A.J., J. Biol. Chem., 1987, vol. 262, no. 14, pp. 6683–6690.
Lamb, D.C., Phil. Trans. R. Soc., vol. 368, p. 20120434.
Mueller, E.J., Loida, P.J., and Sligar, S.G., in Cytochrome P450: Structure, Mechanism, and Biochemistry, 2nd ed., Ortiz De Montellano, P.R., Ed., New York: Plenum Press, 1995, pp. 83–124.
Lewis, D.F.V. and Pratt, J.M., Drug Metab. Rev., 1998, vol. 30, pp. 739–786.
Goeptar, A.R., Scheerens, H., and Vermeulen, N.P.E., Crit. Rev. Toxicol., 1995, vol. 25, pp. 25–65.
Guengerich, F.P., Chem. Res. Toxicol., 2001, vol. 14, pp. 611–650.
Yasui, H., Hayashi, S., and Sakurai, H., Drug Metab. Pharmacokinet., 2005, vol. 20, no. 1, pp. 1–13.
Belcher, J., McLean, K.J., Matthews, S., Woodward, L.S., Fisher, K., Rigby, S.E.J., Nelson, D.R., Potts, D., Baynham, M.T., Parker, D.A., Leys, D., and Munro, A.W., J. Biol. Chem., 2014, vol. 289, no. 10, pp. 6535–6550.
Girvan, H.M. and Munro, A.W., Curr. Opin. Chem. Biol., 2016, vol. 31, pp. 136–145.
Lyakhovich, V.V., Vavilin, V.A., Zenkov, N.K., and Men’shchikova, E.B., Byul. SO RAMN, 2005, no. 4, pp. 7–12.
Osada, M., Ogura, Y., Yasui, H., and Sakurai, H., Biochem. Biophys. Res. Commun., 1999, vol. 263, no. 2, pp. 392–397.
Zenkov, N.K., Lankin, V.Z., and Men’shchikova, E.B., Okislitel’nyi stress. Biokhimicheskii i patofiziologicheskii aspekty (Oxidative Stress: Biochemical and Pathophysiological Aspects), Moscow MAIK. Nauka/Interperiodika, 2001.
Coon, M.J., Vaz, A.D., McGinnity, D.F., and Peng, H.M., Drug Metab. Dispos., 1998, vol. 26, pp. 1190–1193.
Sazykin, I.S. and Sazykina, M.A., Voda: Khim. Ekol., 2013, no. 3, pp. 75–80.
Sazykin, I., Sazykina, M., Khmelevtsova, L., Khammami, M., Karchava, S., and Kudeevskaya, E., Ann. Microbiol., 2016. doi 10.1007/s13213-015-1188-9
Smirnov, L.P., Sukhovskaya, I.V., and Borvinskaya, E.V., Uch. Zap. Petrozavodsk. Gos. Univ., Ser. Biol. Nauki, 2015, no. 4, pp. 18–23.
Katagiri, M., Ganguli, B.N., and Gunsalus, I.C., J. Biol. Chem., 1968, vol. 243, pp. 3543–3546.
Cardini, G. and Jurtshuk, P., J. Biol. Chem., 1968, vol. 243, pp. 6070–6072.
Yasutake, Y., Kitagawa, W., Hata, M., Nishioka, T., Ozaki, T., Nishiyama, M., Kuzuyama, T., and Tamura, T., FEBS Lett., 2014, vol. 588, pp. 105–110.
Moody, S.C. and Loveridge, E. J., J. Appl. Microbiol., 2014, vol. 117, pp. 1549–1563.
Han, S., Pham, T.-V., Kim, J.-H., Lim, Y.-R., Park, H.-G., Cha, G.-S., Yunb, C.-H, Chunc, Y.-J., Kang, L.-W., and Kim, D., Arch. Biochem. Biophys., 2015, vol. 575, pp. 1–7.
Bowman, J.S. and Deming, J.W., BMC Genomics, 2014, vol. 15, p. 1120. doi 10.1186/1471-2164-15-1120
van Beilen, J.B. and Funhoff, E.G., Appl. Microbiol. Biotechnol., 2007, vol. 74, pp. 13–21.
Liu, R., Gao, Y., Ji, Y., Zhang, Y., and Yang, M., Water Sci. Technol., 2015, vol. 71, no. 1, pp. 75–82.
Lamb, D.C., Lei, L., Warrilow, A.G.S., Lepesheva, G.I., Mullins, J.G.L., Waterman, M.R., and Kelly, S.L., J. Virol., 2009, vol. 83, no. 16, pp. 8266–8269.
Chenge, J., Kavanagh, M.E., Driscoll, M.D., McLean, K.J., Young, D.B., Cortes, T., Matak-Vinkovic, D., Levy, C.W., Rigby, S.E.J., Leys, D., Abel, C., and Munro, A.W., Sci. Rep., 2016, vol. 6, no. 26628, pp. 1–12.
Nelson, D.R., Arch. Biochem. Biophys., 1999, vol. 369, pp. 1–10.
Lewis, D.F.V., Guide to Cytochromes P450 Structure and Function, London Taylor and Francis, 2001.
Hrycay, E.G. and Bandiera, S.M., Adv. Exp. Med. Biol., 2016, vol. 851, pp. 1–63.
Munro, A.W., Girvan, H.M., and McLean, K.J., Nat. Prod. Rep., vol. 24, pp. 585–609.
Kelly, S.L. and Kelly, D.E., Phil. Trans. R. Soc. B, 2013, vol. 368, p. 20120 476.
Kitazume, T., Takaya, N., Nakayama, N., and Shoun, H., J. Biol. Chem., 2000, vol. 275, no. 50, pp. 39734–39740.
Warrilow, A.G.S., Melo, N., Martel, C.M., Parker, J.E., Nes, W.D., Kelly, S.L., and Kelly, D.E., Antimicrob. Agents Chemother., 2010, vol. 54, no. 10, pp. 4225–4234.
Werck-Reichhart, D. and Feyereisen, R., Genome Biol., 2000, vol. 1, no. 6, p. 9.
Minerdi, D., Sadeghi, S.J., Di Nardo, G., Rua, F., Castrignanò, S., Allegra, P., and Gilardi, G., Mol. Microbiol., 2015, vol. 95, no. 3, pp. 539–554.
English, N., Hughes, V., and Wolf, C.R., Biochem. J., 1996, vol. 316, pp. 279–283.
Malandain, C., Fayolle-Guichard, F., and Vogel, T.M., FEMS Microbiol. Ecol., 2010, vol. 72, pp. 289–296.
Rojo, F., Env. Microbiol., 2009, vol. 11, no. 10, pp. 2477–2490.
van Beilen, J.B., Funhoff, E.G., van Loon, A., Just, A., Kaysser, L., Bouza, M., Holtackers, R., Röthlisberger, M., Li, Z., and Witholt, B., Appl. Environ. Microbiol., 2006, vol. 72, no. 1, pp. 59–65.
Maier, T., Förster, H.-H., Asperger, O., and Hahn, U., Biochem. Biophys. Res. Commun., 2001, vol. 286, pp. 652–658.
Funhoff, E.G., Bauer, U., Garcia-Rubio, I., Witholt, B., and van Beilen, J.B., J. Bacteriol., 2006, vol. 188, no. 14, pp. 5220–5227.
Du, L., Ma, L., Qi, F., Zheng, X., Jiang, C., Li, A., Wan, X., Liu, S.-J., and Li, S., J. Biol. Chem., 2016, vol. 291, pp. 6583–6594.
Bell, S.G. and Wong, L.-L., Biochem. Biophys. Res. Commun., 2007, vol. 360, no. 3, pp. 666–672.
Leont'ev, V.N., Ignatovets, O.S., and Akhramovich, T.I., Trudy BGTU. Khim. Tekhnol. Org. Veshchestv Biotekhnol., 2009, vol. 1, no. 4, pp. 174–177.
Bernstein, A., Adar, E., Nejidat, A., and Ronen, Z., Biodegradation, 2011, vol. 22, pp. 997–1005.
Le, T.-K., Jang, H.-H., Nguyen, H.T.H., Doan, T.T.M., Lee, G.-Y., Park, K.D., Ahnc, T., Jounga, Y.H., Kang, H.-S., and Yun, C.-H., Enzyme Microb.Technol., 2017, vol. 97, pp. 34–42.
Liu, X., Synthet. Systems Biotechnol., 2016, vol. 1, no. 2, pp. 95–108.
Stok, J.E., Hall, E.A., Stone, I.S.J., Noble, M.C., Wong, S.H., Bell, S.G., and De Voss, J.J., J. Mol. Catal., 2016, vol. 128, pp. 52–64.
Milhim, M., Putkaradze, N., Abdulmughni, A., Kern, F., Hartz, P., and Bernhardt, R., J. Biotechnol., 2016, vol. 240, pp. 68–75.
Zhu, Y., Hassan, Y.I., Watts, C., and Zhou, T., Anim. Feed Sci. Technol., 2016, vol. 216, pp. 19–29.
Ito, M., Sato, I., Ishizaka, M., Yoshida, S.-I., Koitabashi, M., Yoshida, S., and Tsushima, S., Appl. Environ. Microbiol., 2013, vol. 79, no. 5, pp. 1619–1628.
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Original Russian Text © L.E. Khmelevtsova, I.S. Sazykin, M.A. Sazykina, E.Yu. Seliverstova, 2017, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2017, Vol. 53, No. 4, pp. 363–372.
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Khmelevtsova, L.E., Sazykin, I.S., Sazykina, M.A. et al. Prokaryotic cytochromes P450 (Review). Appl Biochem Microbiol 53, 401–409 (2017). https://doi.org/10.1134/S0003683817040093
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DOI: https://doi.org/10.1134/S0003683817040093