Abstract
The existence of cannabis dependence has been questioned for a long time (Murray et al., 2007). This debate has partly stemmed from an outdated view on substance use disorders (SUDs; Leshner, 1997), which measured the relative harm of substances of abuse through the severity of physical dependence (tolerance and withdrawal). In 1964, the World Health Organization recognized psychological dependence as the driving force behind SUDs, rather than physical dependence (Eddy et al., 1965). However, the minimal withdrawal symptoms associated with chronic cannabis use still supported the consensus that cannabis was not addictive (Murray et al., 2007).
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References
Agosti, V., & Levin, F. R. (2004). ‘Predictors of treatment contact among individuals with cannabis dependence’, The American Journal of Drug and Alcohol Abuse, 30, 121–7.
Aracil-Fernandez, A., Almela, P., & Manzanares, J. (2013). ‘Pregabalin and topiramate regulate behavioural and brain gene transcription changes induced by spontaneous cannabinoid withdrawal in mice’, Addiction Biology, 18, 252–62.
Asmaro, D., Carolan, P. L., & Liotti, M. (2014). ‘Electrophysiological evidence of early attentional bias to drug-related pictures in chronic cannabis users’, Addictive Behaviors, 39, 114–21.
Beraha, E. M., Cousijn, J., Hermanides, E., Goudriaan, A. E., & Wiers, R. W. (2013). ‘Implicit associations and explicit expectancies toward cannabis in heavy cannabis users and controls’, Frontiers in Psychiatry, 4, 59.
Bickel, W. K., Yi, R., Landes, R. D., Hill, P. R, & Baxter, C. (2011). ‘Remember the future: Working memory training decreases delay discounting among stimulant addicts’, Biological Psychiatry, 69, 260–5.
Boggio, P. S., Zaghi, S., Villani, A. B., Fecteau, S., Pascual-Leone, A., & Fregni, F. (2010). ‘Modulation of risk-taking in marijuana users by transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC)’, Drug and Alcohol Dependence, 112, 220–5.
Budney, A. J., Vandrey R. G., Hughes, J. R., Thostenson, J. D., & Bursac, Z. (2008). ‘Comparison of cannabis and tobacco withdrawal: Severity and contribution to relapse’, Journal of Substance Abuse Treatment, 35, 362–8.
Chauchard, E., Septfons, A., & Chabrol, H. (2013). ‘Motivations for cannabis cessation, coping and adaptation strategies, and perceived benefits: Impact on cannabis use relapse and abstinence’, Encephale, 39, 385–92.
Chung, T., Martin, C. S., Cornelius, J. R., & Clark, D. B. (2008). ‘Cannabis withdrawal predicts severity of cannabis involvement at 1-year follow-up among treated adolescents’, Addiction, 103, 787–99.
Clapper, J. R., Mangieri, R. A., & Piomelli, D. (2009). ‘The endocannabinoid system as a target for the treatment of cannabis dependence’, Neuropharmacology, 56 Suppl 1, 235–43.
Cornelius, J. R., Chung, T., Martin, C., Wood, D. S., & Clark, D. B. (2008). ‘Cannabis withdrawal is common among treatment-seeking adolescents with cannabis dependence and major depression, and is associated with rapid relapse to dependence’, Addictive Behaviors, 33, 1500–5.
Cousijn, J. (2012). ‘A joint approach: Brain structure and function in heavy cannabis users and their relationship with future use’ (Doctoral Dissertation). Retrieved from http://dare.uva.nl/en/record/431855
Cousijn, J., Goudriaan, A. E., Ridderinkhof, K. R., van den Brink, W., Veltman, D. J., & Wiers, R. W. (2012). ‘Approach-bias predicts development of cannabis problem severity in heavy cannabis users: Results from a prospective fMRI study’, PLoS one, 7, e42394.
Cousijn, J., Goudriaan, A. E., & Wiers, R. W. (2011). ‘Reaching out towards cannabis: Approach-bias in heavy cannabis users predicts changes in cannabis use’, Addiction, 106, 1667–74.
Cousijn, J., Watson, P., Koenders, L., Vingerhoets, W A., Goudriaan, A. E., & Wiers, R. W. (2013). ‘Cannabis dependence, cognitive control and attentional bias for cannabis words’, Addictive Behaviors, 38, 2825–32.
Cousijn, J., Wiers, R. W., Ridderinkhof, K. R., van den Brink, W, Veltman, D. J., & Goudriaan, A. E. (2013a). ‘Effect of baseline cannabis use and working-memory network function on changes in cannabis use in heavy cannabis users: A prospective fMRI study’, Human Brain Mapping, 35(5), 2470–82.
Cousijn, J., Wiers, R. W., Ridderinkhof, K. R., van den Brink, W., Veltman, D. J., Porrino, L. J., & Goudriaan, A. E. (2013b). ‘Individual differences in decision making and reward processing predict changes in cannabis use: A prospective functional magnetic resonance imaging study’, Addiction Biology, 6, 1013–23.
Dekker, N., Smeerdijk, A. M., Wiers, R. W, Duits, J. H., van Gelder, G., Houben, K., … de Haan, L. (2010). ‘Implicit and explicit affective associations towards cannabis use in patients with recent-onset schizophrenia and healthy controls’, Psychological Medicine, 40, 1325–36.
Eberl, C., Wiers, R. W., Pawelczack, S., Rinck, M., Becker, E. S., & Lindenmeyer, J. (2013). ‘Approach bias modification in alcohol dependence: Do clinical effects replicate and for whom does it work best?’, Developmental Cognitive Neuroscience, 4, 38–51.
Eddy, N. B., Halbach, H., Isbell, H., & Seevers, M. H. (1965). ‘Drug dependence: Its significance and characteristics’, Bulletin of the World Health Organization, 32, 721–33.
Everitt, B. J., & Robbins, T. W. (2005). ‘Neural systems of reinforcement for drug addiction: From actions to habits to compulsion’, Nature Neuroscience, 8, 1481–9.
Fadardi, J. S., & Cox, W. M. (2009). ‘Reversing the sequence: Reducing alcohol consumption by overcoming alcohol attentional bias’, Drug and Alcohol Dependence, 101, 137–45.
Fernandez-Serrano, M. J., Perez-Garcia, M., & Verdejo-Garcia, A. (2011). ‘What are the specific vs. generalized effects of drugs of abuse on neuropsychological performance?’, Neuroscience and Biobehavioral reviews, 35, 377–406.
Field, M., Eastwood, B., Bradley, B. P., & Mogg, K. (2006). ‘Selective processing of cannabis cues in regular cannabis users’, Drug and Alcohol Dependence, 85, 75–82.
Florez-Salamanca, L., Secades-Villa, R., Budney A. J., Garcia-Rodriguez, O., Wang, S., & Blanco, C. (2013). ‘Probability and predictors of cannabis use disorders relapse: Results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)’, Drug and Alcohol Dependence, 132, 127–33.
Goldstein, R. Z., & Volkow, N. D. (2002). ‘Drug addiction and its underlying neurobiological basis: Neuroimaging evidence for the involvement of the frontal cortex’, The American Journal of Psychiatry, 159, 1642–52.
Gore, R., & Earleywine, M. (2007). ‘Marijuana’s perceived addictiveness: A survey of clinicians and researchers’. In M. Earleywine (Ed.), Pot politics: Marijuana and the costs of prohibition. (New York, NY: Oxford University Press).
Gray, K. M., Larowe, S. D., Watson, N. L., & Carpenter, M.J. (2011). ‘Reactivity to in vivo marijuana cues among cannabis-dependent adolescents’, Addictive Behaviors, 36, 140–3.
Gray, K. M., Watson, N. L., Carpenter, M. J., & Larowe, S. D. (2010). ‘N-acetylcysteine (NAC) in young marijuana users: An open-label pilot study’, The American Journal on Addictions, 19, 187–9.
Haney M., Hart, C. L., Vosburg, S. K., Comer, S. D., Reed, S. C., & Foltin, R. W. (2008). ‘Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse’, Psychopharmacology (Berlin, Germany), 197, 157–68.
Haney, M., Ward, A. S., Comer, S. D., Hart, C. L., Foltin, R. W., & Fischman, M. W. (2001). ‘Bupropion SR worsens mood during marijuana withdrawal in humans’, Psychopharmacology (Berlin, Germany), 155, 171–9.
Huestis, M. A., Gorelick, D. A., Heishman, S. J., Preston, K. L., Nelson, R. A., Moolchan, E. T., & Frank, R. A. (2001). ‘Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716’, Archives of General Psychiatry, 58, 322–8.
Heyman, G. M. (2009). Addiction: A disorder of choice. (Boston, MA: Harvard University Press).
Houben, K., Havermans, R. C., Nederkoorn, C., & Jansen, A. (2012). ‘Beer a no-go: Learning to stop responding to alcohol cues reduces alcohol intake via reduced affective associations rather than increased response inhibition’, Addiction, 107, 1280–7.
Houben, K., Nederkoorn, C., Wiers, R. W., & Jansen, A. (2011). ‘Resisting temptation: Decreasing alcohol-related affect and drinking behavior by training response inhibition’, Drug and Alcohol Dependence, 116, 132–6.
Houben, K., Wiers, R. W., & Jansen, A. (2011). ‘Getting a grip on drinking behavior: Training working memory to reduce alcohol abuse’, Psychological Science, 22, 968–75.
Jansen, J. M., Daams, J. G., Koeter, M. W., Veltman, D. J., van den Brink, W., & Goudriaan, A. E. (2013). ‘Effects of non-invasive neurostimulation on craving: A meta-analysis’, Neuroscience and Biobehavioral Reviews, 37, 2472–80.
Kane, M. J., & Engle, R. W. (2002). ‘The role of prefrontal cortex in working-memory capacity, executive attention, and general fluid intelligence: An individual-differences perspective’, Psychonomic Bulletin & Review, 9, 637–71.
Keren, G., & Schul, Y. (2009). ‘Two is not always better than one: A critical evaluation of two-system theories’, Perspectives on Psychological Science, 4, 533–50.
Leshner, A. I. (1997). ‘Addiction is a brain disease, and it matters’, Science, 278, 45–7.
Levin, F. R., & Kleber, H. D. (2008). ‘Use of dronabinol for cannabis dependence: Two case reports and review’, The American Journal of Addictions, 17, 161–4.
Lundahl, L. H., & Johanson, C. E. (2011). ‘Cue-induced craving for marijuana in cannabis-dependent adults’, Experimental and Clinical Psychopharmacology, 19, 224–30.
McRae-Clark, A. L., Carter, R. E., Killeen, T. K., Carpenter, M. J., Wahlquist, A. E., Simpson, S. A., & Brady, K. T. (2009). A placebo-controlled trial of buspirone for the treatment of marijuana dependence’, Drug and Alcohol Dependence, 105, 132–8.
Morrison, A. B., & Chein, J. M. (2011). ‘Does working memory training work? The promise and challenges of enhancing cognition by training working memory’, Psychonomic Bulletin & Review, 18, 46–60.
Murray, R. M., Morrison, P. D., Henquet, C., & Di Forti, M. (2007). ‘Cannabis, the mind and society: The hash realities’, Nature Reviews Neuroscience, 8, 885–95.
Nutt, D. J., King, L. A., & Phillips, L. D. (2010). ‘Drug harms in the UK: A multicriteria decision analysis’, Lancet, 376, 1558–65.
Ochsner, K. N., Silvers, J. A., & Buhle, J. T. (2012). ‘Functional imaging studies of emotion regulation: A synthetic review and evolving model of the cognitive control of emotion’, Annals of the New York Academy of Sciences, 1251, E1–24.
Orford, J. (2001). ‘Addiction as excessive appetite’, Addiction, 96, 15–31.
Rahioui, H., Benyamina, A., & Reynaud, M. (2005). ‘Treatment of cannabis dependence’, La Revue du Praticien, 55, 64–70; discussion 71–2.
Rinck, M., & Becker, E. S. (2007). ‘Approach and avoidance in fear of spiders’, Journal of Behavior Therapy and Experimental Psychiatry, 38, 105–20.
Robinson, T. E., & Berridge, K. C. (2003). ‘Addiction’, Annual Review of Psychology, 54, 25–53.
Schoenmakers, T., De Bruin, M., Lux, I. R, Goertz, A. G., van Kerkhof, D. H., & Wiers, R. W. (2010). ‘Clinical effectiveness of attentional bias modification training in abstinent alcoholic patients’, Drug and Alcohol Dependence, 109, 30–6.
Shafa, R. (2009). ‘COMT-inhibitors may be a promising tool in treatment of marijuana addiction trials’, The American Journal on Addictions, 18, 322.
Sugarman, D. E., Poling, J., & Sofuoglu, M. (2011). ‘The safety of modafinil in combination with oral 9-tetrahydrocannabinol in humans’, Pharmacololgy, Biochemistry, and Behavior, 98, 94–100.
Tirado, C. F., Goldman, M., Lynch, K., Kampman, K. M., & O’Brien, C. P. (2008). ‘Atomoxetine for treatment of marijuana dependence: A report on the efficacy and high incidence of gastrointestinal adverse events in a pilot study’, Drug and Alcohol Dependence, 94, 254–7.
United Nations Office on Drugs and Crime. (2009). World Drug Report. Retrieved from http://www.unodc.org/documents/wdr/WDR_2009/WDR2009_eng_web.pdf
van der Pol, P., Liebregts, N., de Graaf, R., Ten Have, M., Korf, D. J., van den Brink, W., & van Laar, M. (2013). ‘Mental health differences between frequent cannabis users with and without dependence and the general population’, Addiction, 108, 1459–69.
Vandrey R., & Haney M. (2009). ‘Pharmacotherapy for cannabis dependence: How close are we?’ CNS Drugs, 23, 543–53.
Vandrey, R., Stitzer, M. L., Mintzer, M. Z., Huestis, M. A., Murray, J. A., & Lee, D. (2013). ‘The dose effects of short-term dronabinol (oral THC) maintenance in daily cannabis users’, Drug and Alcohol Dependence, 128, 64–70.
Wachtel, S. R., & de Wit, H. (2000). ‘Naltrexone does not block the subjective effects of oral Delta(9)-tetrahydrocannabinol in humans’, Drug and Alcohol Dependence, 59, 251–60.
Weinstein, A. M., & Gorelick, D. A. (2011). ‘Pharmacological treatment of cannabis dependence’, Current Pharmaceutical Design, 17, 1351–8.
Wiers, R. W., Bartholow, B. D., van den Wildenberg, E., Thush, C., Engels, R. C., Sher, K. J., … Stacy, A. W. (2007). ‘Automatic and controlled processes and the development of addictive behaviors in adolescents: A review and a model’, Pharmacology, Biochemistry, and Behavior, 86, 263–83.
Wiers, R. W., Eberl, C., Rinck, M., Becker, E. S., & Lindenmeyer, J. (2011). ‘Retraining automatic action tendencies changes alcoholic patients’ approach bias for alcohol and improves treatment outcome’, Psychological Science, 22, 490–7.
Wiers, R. W., Gladwin, T. E., Hofmann, W., Salemink, E., & Ridderinkhof, K. R. (2013). ‘Cognitive bias modification and cognitive control training in addiction and related psychopathology: Mechanisms, clinical perspectives, and ways forward’, Clinical Psychological Science, 1, 192–212.
Zumdick, S., Schneider, U., Leweke, M., Julicher, A., Tossmann, P., & Bonnet, U. (2006). ‘A survey on trials focussing on the treatment of cannabis-dependence’, Fortschritte der Neurologie-Psychiatrie, 74, 211–25.
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© 2015 Janna Cousijn and Francesca Filbey
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Cousijn, J., Filbey, F. (2015). New Approaches to Treating Cannabis Dependence: From Neuroscience to Practice. In: Ewing, S.W.F., Witkiewitz, K., Filbey, F.M. (eds) Neuroimaging and Psychosocial Addiction Treatment. Palgrave Macmillan, London. https://doi.org/10.1057/9781137362650_7
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DOI: https://doi.org/10.1057/9781137362650_7
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