Abstract
Heatstroke is a life-threatening event that affects people worldwide. Currently, there are no established tools to predict the outcomes of heatstroke. Although the Sequential Organ Failure Assessment (SOFA) score is a promising tool for judging the severity of critically ill patients. Therefore, in this study, we investigated whether the SOFA score could predict the outcome of patients hospitalized with severe heatstroke, including the classical and exertional types, by using data from a Japanese nationwide multicenter observational registry. We performed retrospective subanalyses of the Japanese Association for Acute Medicine heatstroke registry, 2019. Adults with a SOFA score ≥ 1 hospitalized for heatstroke were analyzed. We analyzed data for 225 patients. Univariate and multivariable analyses showed a significant difference in the SOFA score between non-survivors and survivors in classical and exertional heatstroke cases. The area under the receiver operating characteristic curve were 0.863 (classical) and 0.979 (exertional). The sensitivity and specificity of SOFA scores were 50.0% and 97.5% (classical), 66.7% and 97.5% (exertional), respectively, at a cutoff of 12.5, and 35.0% and 98.8% (classical), 33.3% and 100.0% (exertional), respectively, at a cutoff of 13.5. This study revealed that the SOFA score may predict mortality in patients with heatstroke and might be useful for assessing prognosis.
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Introduction
Heatstroke is a pathologic event that is internationally defined by the triad of hyperthermia, neurologic abnormalities, and exposure to hot weather or physical exertion. It affects people worldwide and is potentially hazardous due to increased risk of mortality. The causes of heatstroke are generally divided into classical causes, such as passive heatstroke in a hot environment, and exertional causes, which are associated with physical exercise. Regardless of cause, heatstroke is potentially life-threatening due to the risk of central nervous system dysfunction and multiple organ failure1.
Although some efforts have been made to recognize and define the severity of heatstroke, and hence predict the mortality and neurological status at discharge, there are still no internationally agreed definitions of the severity of heatstroke. Some reports have suggested that advanced age, disturbed consciousness, elevated serum creatinine (Cre) and total bilirubin (T-bil) levels, and coagulation disorder are risk factors for death2,3. In reports that focused on exertional heatstroke, acute kidney injury4 and myocardial injury5 were identified as risk factors. Other groups have also developed a scoring system (exertional heat stroke score [EHSS]) for classifying the severity of exertional heatstroke6,7.
Despite these efforts, a definitive tool for predicting the outcome of heatstroke that may be useful for assessing the prognosis has not yet been developed. Therefore, in this study, we evaluated a tool that may predict the outcome of heatstroke. In selecting the tool, we felt that the following factors were important when predicting mortality: (1) the tool should be available for classical and/or exertional heatstroke; (2) the tool could be used to assess heatstroke with multiple organ disfunction (we felt it was unnecessary to judge non-life-threatening cases); (3) the tool could use information recorded early, at the time of admission or hospitalization; and (4) the tool should be commonly available.
Internationally, the Sequential Organ Failure Assessment (SOFA) score is widely used to assess multiple organ dysfunction or failure as the main causes of death in critically ill patients8. Prior studies have suggested that the SOFA score is also useful for predicting mortality in patients with heatstroke3,4,5,6,7,9,10. However, those studies exhibited some weaknesses, including the use of populations comprising only exertional heatstroke, and single-center designs.
We therefore considered that the SOFA score could be a useful tool for assessing the risk of mortality in patients with severe classical or exertional heatstroke. Accordingly, we investigated the prognostic potential of the SOFA score using data from a Japanese nationwide multicenter observational registry collated annually by the Japanese Association of Acute Medicine (JAAM) (JAAM heatstroke registry).
Our hypothesis was that the early SOFA score predicts the mortality risk in both types of heatstroke, even in severe cases, and we tested it using the JAAM heatstroke registry.
Methods
Study design
In the present study, we performed retrospective analyses of data from the JAAM heatstroke registry, a nationwide multicenter observational registry collated annually since 2014 by the JAAM11. In 2019 (1 July–30 September), 148 hospitals participated in data collection (see acknowledgements). Patients were eligible for the registry if they were judged as having heat-related illness by the hospitals’ physicians and hospitalized. Anonymized medical data were entered into the registry using the JAAM online system. This registry database was mainly managed by Teikyo University Hospital. The registry protocol was approved by the ethics committee at Teikyo University Hospital. The participating hospitals also obtained approval from their ethics committees as necessary. And, this retrospective observational study was approved by ethics committees at Mie University Hospital, by using Ethical Guidelines for Medical and Biological Research Involving Human Subjects from Japanese government. Informed consent was obtained from all the study participants.
Patients
The JAAM heatstroke registry is collated annually, and we used data recorded in 2019. Between 1 July and 30 September in 2019, a total of 734 patients were hospitalized for heatstroke and registered. For the present analyses, we retrieved data for patients with a SOFA score ≥ 1, excluding patients without multiple organ dysfunction in whom the SOFA score was not calculated. All of the patients were over 15 years old without intentional entry protocol.
Study outcomes and statistical analysis
The eligible cases were divided into two groups of classical and exertional heatstroke, and statistical analysis were performed as follows. The following variables were retrieved retrospectively from the database: age, sex, outside onset, vital signs on admission (respiratory rate [RR], heart rate [HR], systolic and diastolic blood pressure [sBP and dBP], Glasgow Coma Score [GCS], and surface and core (rectum, bladder, esophagus, etc.) body temperature [sBT and cBT]), laboratory data on admission (pH, lactate, platelet count, prothrombin time [PT], T-bil, and Cre), Acute Physiology and Chronic Health Evaluation (APACHE) II score, SOFA score, and 28-day mortality. For this study, we used 28-day mortality as the outcome variable.
The patients were divided into two groups (non-survivor and survivors) based on their survival at 28 days. We compared the clinical data between these two groups using univariate and multivariable analyses. Univariate analyses were performed using the Mann–Whitney U test or Fisher’s exact test, as appropriate. Multivariable analyses were performed using logistic regression analysis, in which the dependent variable was 28-day mortality and the explanatory variables were age, sex (male), outside onset, RR, HR, sBP, dBP, cBT, pH, lactate, SOFA score, and APACHE II score. sBT was excluded from the analysis because of its correlation with cBT. GCS, platelet count, PT, T-bil, and Cre were also excluded because these are used to calculate the SOFA score. Receiver operating characteristic (ROC) curve analysis was performed to plot the SOFA score against 28-day mortality, and the area under the curve (AUC) was calculated. Sensitivity and specificity were calculated using the curve for individual cutoff values of the SOFA score.
In all analyses, a P-value of < 0.05 was considered statistically significant. All statistical analyses were performed with SPSS version 25.0 (IBM, Armonk, NY, USA).
Ethical approval and consent to participate
The registry was approved by the ethics committees at Teikyo University and at the participating institutions and hospitals, as necessary. This retrospective observational study was approved by ethics committees at Mie University Hospital, by using Ethical Guidelines for Medical and Biological Research Involving Human Subjects from Japanese government. Informed consent was obtained from all the study participants.
Results
The registry comprised 734 patients, of which 225 met the inclusion criteria (i.e., SOFA score ≥ 1; Fig. 1). Therefore, the inclusion rate was 31% (225/734).
Table 1 shows the characteristics of the patients included in this analysis (all, classical, and exertional cases). The median age was 74 years, 72% of patients were male, 51% suffered heatstroke outside, and the median SOFA and APACHE II scores were 6 and 23, respectively. The survival status at 28 days was recorded in 146 of 225 patients (65%) and the 28-day mortality rate among these patients was 16% (24/146). Between classical and exertional cases, age, sex, outside onset, blood pressure, sBT, platelet, PT, and T-bil showed significant difference, and exertional cases shoed about 20 years younger age. Core body temperature was measured by 67% of bladder, 27% of rectum, 2% of esophagus, and etc.
Table 2 compares the clinical data between the non-survivors (n = 20) and survivors (n = 80) at 28 days in classical cases. The univariate analyses revealed significant differences between these two groups in terms of sBP, dBP, GCS, cBT, lactate, platelet, PT, Cre, SOFA score (P < 0.001), and APACHE II score. In the multivariable analysis, there were significant differences between the two groups in terms of sex and SOFA score (odds ratio [OR] 1.973 [95% confidence interval [CI] 1.050–3.706], P = 0.035).
Table 3 compares the clinical data between the non-survivors (n = 3) and survivors (n = 40) at 28 days in exertional cases. The univariate analyses revealed significant differences between these two groups in terms of GCS, PT, and SOFA score (P = 0.001). The multivariable analysis could not be calculated.
Figure 2 shows a bar graph of the mortality rate according to the SOFA score in each classical and exertional cases. Refer to both bar graphs, these demonstrates a correlation between SOFA score and mortality rate, with a dramatic increase in the mortality rate in patients with a SOFA score ≥ 13.
Figure 3 and Table 4 show the results of the ROC analysis of SOFA score and 28-day mortality in classical and exertional cases. The AUC were 0.863 (P < 0.001) and 0.979 (P = 0.006), respectively. From both ROC analysis, at a SOFA score cutoff value of 12.5, both specificity was more than 95%, each the sensitivity and specificity were 50.0% and 97.5%, 66.7% and 97.5%, respectively, At the cutoff value of 13.5, each the sensitivity and specificity were 35.0% and 98.8%, 33.3% and 100.0%, respectively.
Discussion
In the present study, univariate and multivariable analysis revealed a significant association between the SOFA score and 28-day mortality in each classical and exertional heatstroke patients hospitalized for multiple organ dysfunction. The ROC analysis of SOFA score and 28-day mortality was also significant with an AUC of 0.863 (P < 0.001) and 0.979 (P = 0.006), respectively.
Some reports have revealed the potential usefulness of the SOFA score3,4,5,6,7,9,10. Here, we have also shown an advantage of using SOFA score for predicting the outcome of patients included in the heatstroke database. The study population were hospitalized for classical or exertional heatstroke, and we eliminated patients without a SOFA score (in other words excluding mild and moderate cases). The results therefore suggest that the SOFA score may predict the outcome of heatstroke, particularly for severe cases.
Heatstroke is disease related to fever and, from a pathophysiological perspective, non-septic fever could show more rapid deterioration than sepsis-related fever. Nevertheless, the pathology of systemic damage and progression of multiorgan dysfunction are thought to overlap12. The SOFA score was previously shown to be useful for predicting in-hospital mortality in patients with sepsis13. Based on the present results, the SOFA score may be a reliable tool for assessing the prognosis of heatstroke, a non-septic fever, as demonstrated in patients with sepsis. Nevertheless, other factors may be needed in combination with the SOFA score to improve the accuracy of predicting the prognosis of heatstroke.
Other studies have sought to establish a new scoring scale for heatstroke. Yang et al. reported that the exertional heatstroke score (EHSS; based on body temperature, GCS, pH, lactate, PT, fibrinogen, troponin I, aspartate transaminase, T-bil, Cre, and acute gastrointestinal injury) showed potential for predicting the outcome of heatstroke and was evaluated in several studies6,7. Many of the parameters used in that EHSS score were also strong factors in our study. In fact, GCS, platelet, PT, and Cre differed significantly between non-survivors and survivors in univariate analyses. However, these variables are used to calculate the SOFA score and were therefore excluded from the multivariable analysis to avoid confounding. The ROC curve analyses in earlier studies showed superiority of the EHSS versus the SOFA score (EHSS score showed both sensitivity and specificity were more than 90%). However, if these tools are used for assessing prognosis, high sensitivity with 100% specificity (or at least 98%–99%) is needed. Therefore, the EHSS should be improved to increase sensitivity while retaining high specificity, which was < 50% in their study6. As tools for assessing prognosis, neither the EHSS nor the SOFA score displayed sufficient sensitivity.
To improve the predictive value of the SOFA score, lactate could be included as a candidate variable because it showed statistical significance in the univariate analysis. In fact, prior studies have already demonstrated the use of lactate for predicting mortality in critical care patients14, and a combination of lactate and SOFA score has been already applied in sepsis, with a pathology of shock and multiple organ dysfunction15. Accordingly, a combination of lactate and SOFA score is worth investigating in order to improve the predictive and prognostic value in heatstroke.
This study has several limitations. First, although we used data from a nationwide cohort, the study was performed retrospectively, which may introduce some bias. Second, the survival status at 28 days was only recorded for a proportion of patients (65%, 146/225), which may reduce data quality. Third, although we performed multivariable analysis, there might be residual confounding or other factors that may influence the results. Fourth, 28-day mortality was used as the outcome of interest in this study; the results may differ if we used 6-month or 1-year mortality. Fifth, our database did not have prehospital care information, there was a possibility that prehospital treatment might affect the outcome.
Conclusions
These subanalyses of a Japanese nationwide multicenter observational heatstroke database using data from 2019 revealed that the SOFA score may be useful for predicting mortality and could be used to assess the prognosis of patients with severe heatstroke.
Data availability
The datasets used during the current study available from the corresponding author on reasonable request.
Abbreviations
- EHSS:
-
Exertional heatstroke scale
- SOFA:
-
Sequential organ failure assessment
- JAAM:
-
Japanese association of acute medicine
- HR:
-
Heart rate
- RR:
-
Respiratory rate
- sBP:
-
Systolic blood pressure
- dBP:
-
Diastolic blood pressure
- PT:
-
Prothrombin time
- T-bil:
-
Total bilirubin
- Cre:
-
Creatinine
- APACHE:
-
Acute physiology and chronic health evaluation
- ROC:
-
Receiver operating characteristic
- AUC:
-
Area under the curve
- OR:
-
Odds ratio
- CI:
-
Confidence interval
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Acknowledgements
We wish to thank all members of this JAAM multicenter observational heatstroke registry. A list of institutions participating are below. Aichi Medical University Hospital, Aidu Chuo Hospital, Aizawa Hospital, Asahikawa Medical University Hospital, Chiba University Hospital, Daiyukai General Hospital, Dokkyo Medical University Saitama Medical Center, Eastern Chiba Medical Center, Ehime Prefectural Central Hospital, Fujieda Municipal General Hospital, Fujisawa City Hospital, Fukui Prefectural Hospital, Funabashi Municipal Medical Center, Gifu Prefectural General Medical Center, Gifu University Hospital, Hamamatsu Medical Center, Handa City Hospital, Hiroshima City Hiroshima Citizens Hospital, Hyogo Prefectural Awaji Medical Center, Hyogo Prefectural Kakogawa Medical Center, Hyogo Prefectural Nishinomiya Hospital, Ichinomiya Municipal Hospital, Iizuka Hospital, Ina Central Hospital, Ishikawa Prefectural Central Hospital, Iwata City Hospital, Japanese Red Cross Ise Hospital, Japanese Red Cross Ishinomaki Hospital, Japanese Red Cross Kyoto Daini Hospital, Japanese Red Cross Maebashi Hospital, Japanese Red Cross Medical Center, Japanese Red Cross Narita Hospital, Japanese Red Cross Shizuoka Hospital, Japanese Red Cross Tokushima Hospital, Jichi Medical University Saitama Medical Center, Juntendo University Nerima hospital, Juntendo University Urayasu Hospital, Kagawa Prefectural Central Hospital, Kasugai Municipal Hospital, Kawasaki Municipal Hospital, Kitakyushu General Hospital, Kochi Health Sciences Center, Kurume University Hospital, Kushiro City General Hospital, Kyorin University Hospital, Kyoto University Hospital, Kyushu University Hospital, Mie University Hospital, Mito Saiseikai General Hospital, Nagoya Ekisaikai Hospital, Nagoya University Hospital, National Center for Global Health and Medicine, National Hospital Organization Hokkaido Medical Center, National Hospital Organization Kumamoto Medical Center, National Hospital Organization Osaka National Hospital, National Hospital Organization Takasaki General Medical Center, National Hospital Organization Yokohama Medical Center, Nihon University Hospital, Nihon University Itabashi Hospital, Nihonkai General Hospital, Niigata Prefectural Shibata Hospital, Nippon Medical School Tama Nagayama Hospital, Odawara Municipal Hospital, Oita University Hospital, Okazaki City Hospital, Okinawa Prefectural Chubu Hospital, Ome Municipal General Hospital, Omihachiman Community Medical Center, Osaka City General Hospital, Osaka Mishima Emergency Critical Care Center, Osaka Police Hospital, Osaka Prefectural Nakakawachi Emergency and Critical Care Center, Ota Medical Hospital, Saiseikai Utsunomiya Hospital, Saiseikai Yokohamashi Tobu Hospital, Saitama Medical University International Medical Center, Saku Central Hospital, Sapporo City General Hospital, Sapporo Medical University Hospital, Shinshu University Hospital, Shonan Kamakura General Hospital, Showa University Fujigaoka Hospital, St. Luke's International Hospital, St. Mary's Hospital, Sugita Genpaku Memorial Obama Municipal Hospital, Sunagawa City Medical Center, Teikyo University Hospital, Teine Keijinkai Hospital, The University of Tokyo Hospital, Toho University Omori Medical Center, Tohoku University Hospital, Tokai University Hachioji Hospital, Tokai University Hospital, Tokushima Prefectural Miyoshi Hospital, Tokyo Metropolitan Tama Medical Center, Tokyo Women's Medical University Hospital, Tokyo Women's Medical University Medical Center East, Tokyo Women's Medical University Yachiyo Medical Center, Tosei General Hospital, Toyama Prefectural Central Hospital, Toyama University Hospital, University of Yamanashi Hospital, Yamagata Prefectural Central Hospital, Yamagata University Hospital, Yamaguchi University Hospital, Yamanashi Prefectural Central Hospital, Yokkaichi Municipal Hospital, Yokohama Minami Kyosai Hospital, Yokohama Rosai Hospital.
Funding
This study was supported by the Japanese Society for the Promotion of Science KAKENHI grant (19K18365).
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K.Y and T.K conceived and designed the study, wrote the study protocol, and contributed to the acquisition of clinical data. K.M and T.K performed the statistical analyses and wrote the first draft of the manuscript. K.M and T.K are co-directors of this multicenter observational study. All of the authors reviewed and commented on the manuscript and approved the final version.
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Yokoyama, K., Kaneko, T., Ito, A. et al. Sequential organ failure assessment score as a predictor of the outcomes of patients hospitalized for classical or exertional heatstroke. Sci Rep 12, 16373 (2022). https://doi.org/10.1038/s41598-022-20878-1
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DOI: https://doi.org/10.1038/s41598-022-20878-1
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