Abstract
Intestinal stem and progenitor cells replicate and differentiate in distinct compartments, influenced by Wnt, BMP, and other subepithelial cues. The cellular sources of these signals were long obscure because intestinal mesenchyme was insufficiently characterised. In this Review, we discuss how recent mRNA profiles of mouse and human intestinal submucosa, coupled with fine-resolution microscopy and gene and cell disruptions, reveal a coherent picture of an organised tissue carrying cells with distinct molecular properties and functions.
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Acknowledgements
Work on this topic in the authors’ laboratory is supported by NIH awards R01DK121540, U01DK103152, and F32DK118862.
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McCarthy, N., Kraiczy, J. & Shivdasani, R.A. Cellular and molecular architecture of the intestinal stem cell niche. Nat Cell Biol 22, 1033–1041 (2020). https://doi.org/10.1038/s41556-020-0567-z
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DOI: https://doi.org/10.1038/s41556-020-0567-z
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