Abstract
Background
Selenium is an essential element which shows protective properties against diverse harmful factors. Lithium compounds are widely used in medicine, but, in spite of undoubted beneficial effects, treatment with these compounds may lead to severe side effects, including renal, gastrointestinal, neurological, endocrine and metabolic disorders. This study was aimed at evaluating the influence of selenium and/or lithium on lithium, iron, zinc and copper content in rats’ erythrocytes as well as estimate the action of additional selenium on lithium exposure effects.
Methods
The experiment was performed on four groups of rats (six animals each): control — received saline; Li — received 2.7 mg Li/kg b.w. as lithium carbonate; Se — received 0.5 mg Se/kg b.w. as sodium selenite; Se + Li — received simultaneously 0.5 mg Se/kg b.w. and 2.7 mg Li/kg b.w. (sodium selenite and lithium carbonate). The administration was performed for three weeks, once a day by stomach tube, in form of water solutions. In erythrocytes the content of lithium, iron, zinc and copper was determined using flame atomic absorption spectroscopy.
Results
Lithium treatment insignificantly disturbed iron and zinc homeostasis as well as markedly increased lithium accumulation and copper content in rat erythrocytes. Selenium coadministration reversed those effects.
Conclusions
The beneficial effect of selenium on disturbances of studied microelements homeostasis as well as on preventing lithium accumulation in erythrocytes in Li receiving animals allows suggesting that further research on selenium application as an adjuvant in lithium therapy is worth carrying on.
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Kiełczykowska, M., Kopciał, E., Kocot, J. et al. Lithium disturbs homeostasis of essential microelements in erythrocytes of rats: Selenium as a protective agent?. Pharmacol. Rep 70, 1168–1172 (2018). https://doi.org/10.1016/j.pharep.2018.05.003
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DOI: https://doi.org/10.1016/j.pharep.2018.05.003