Abstract
Replacement of damaged long bones is still a significant challenge in surgery. In the present study, a NiTi Shape Memory Alloy (SMA) constructed with graded porosity imitating human long bone structure was fabricated via a dedicated moulding procedure. The outer layer (porosity 14 %) and inner layer (porosity 52 %) of the bone-like graded NiTi alloy were found to be co-axial very well with the interface with a good metallurgical bonding. Moreover, the compression strength and elastic modulus of the graded-porosity NiTi SMAs were found to be 360.6 MPa and 6.7 GPa, respectively, which have been improved by its coaxiality compared with the one with poor coaxiality. The graded-porosity NiTi SMAs exhibit resembling mechanical performance as human long-bones, and are considered to be better implant candidates for long bone replacement.
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References
Rho J Y, Kuhn-Spearing L, Zioupos P. Mechanical properties and the hierarchical structure of bone. Medical Engineering and Physics, 1998, 20, 92–102.
Cancedda R, Giannoni P, Mastrogiacomo M. A tissue engineering approach to bone repair in large animal models and in clinical practice. Biomaterials, 2007, 28, 4240–4250.
Yoneda M, Terai H, Imai Y, Okada T, Nozaki K, Inoue H, Miyamoto S, Takaoka K. Repair of an intercalated long bone defect with a synthetic biodegradable bone-inducing implant. Biomaterials, 2005, 26, 5145–5152.
Perren S M. Evolution of the internal fixation of long bone fractures. The scientific basis of biological internal fixation: Choosing a new balance between stability and biology. The Journal of Bone and Joint Surgery, 2002, 84, 1093–1110.
Tampieri A, Celotti G, Sprio S, Delcogliano A, Franzese S. Porosity-graded hydroxyapatite ceramics to replace natural bone. Biomaterials, 2001, 22, 1365–1370.
Bearcroft J A, Brosnahan R, Small L A. Artificial Bone Graft Implant, US. Patent No. 6, 149, 688.
Ruff C B. Body size, body shape, and long bone strength in modern humans. Journal of Human Evolution, 2000, 38, 269–290.
Wang M. Developing bioactive composite materials for tissue replacement. Biomaterials, 2003, 24, 2133–2151.
Cooke F W. Ceramics in orthopedic surgery. Clinical Orthopaedics and Related Research, 1992, 276, 135–146.
Hollinger J O, Battistone G C. Biodegradable bone repair materials synthetic polymers and ceramics. Clinical Orthopaedics and Related Research, 1986, 207, 290–306.
Deligianni D D, Katsala N, Ladas S, Sotiropoulou D, Amedee J, Missirlis YF. Effect of surface roughness of the titanium alloy Ti-6Al-4V on human bone marrow cell response and on protein adsorption. Biomaterials, 2001, 22, 1241–1251.
Hsu Y H, Turner I G, Miles A W. Fabrication of porous bioceramics with porosity gradients similar to the bimodal structure of cortical and cancellous bone. Journal of Materials Science: Materials in Medicine, 2007, 18, 2251–2256.
Soon Y M, Shin K H, Koh Y H, Lee J H, Choi W Y, Kim H E. Fabrication and compressive strength of porous hydroxya-patite scaffolds with a functionally graded core/shell structure. Journal of the European Ceramic Society, 2011, 31, 13–18.
Xu J L, Bao L Z, Liu A H, Jin X F, Luo J M, Zhong Z C, Zheng Y F. Effect of pore sizes on the microstructure and properties of the biomedical porous NiTi alloys prepared by microwave sintering. Journal of Alloys and Compounds, 2015, 645, 137–142.
Zhang L, Zhang Y Q, Jiang Y H, Zhou R. Superelastic behaviors of biomedical porous NiTi alloy with high porosity and large pore size prepared by spark plasma sintering. Journal of Alloys and Compounds, 2015, 644, 513–522.
Xu J L, Jin X F, Luo J M, Zhong Z C. Fabrication and properties of porous NiTi alloys by microwave sintering for biomedical applications. Materials Letters, 2014, 124, 110–112.
Huan Z, Fratila-Apachitei L E, Apachitei I, Duszczyk J. Porous NiTi surfaces for biomedical applications. Applied Surface Science, 2012, 258, 5244–5249.
Xu J L, Bao L Z, Liu A H, Jin X J, Tong Y X, Luo J M, Zhong Z C, Zheng Y F. Microstructure, mechanical properties and superelasticity of biomedical porous NiTi alloy prepared by microwave sintering. Materials Science and Engineering C, 2015, 46, 387–393.
Chu C L, Chung C Y, Lin P H, Wang S D. Fabrication of porous NiTi shape memory alloy for hard tissue implants by combustion synthesis. Materials Science and Engineering A, 2004, 366, 114–119.
Chen M F, Yang X J, Hu R X, Cui Z D, Man H C. Bioactive NiTi shape memory alloy used as bone bonding implants. Materials Science and Engineering C, 2004, 24, 497–502.
Bansiddhi A, Sargeant T D, Stupp S I, Dunand D C. Porous NiTi for bone implants: A review. Acta biomaterialia, 2008, 4, 773–782.
Zhang Y P, Li D S, Zhang X P. Gradient porosity and large pore size NiTi shape memory alloys. Scripta Materialia, 2007, 57, 1020–1023.
Fadlallah S A, El-Bagoury N, Gad El-Rab SMF, Ahmed R A, El-Ousamii G. An overview of NiTi shape memory alloy: Corrosion resistance and antibacterial inhibition for dental application. Journal of Alloys and Compounds, 2014, 583, 455–464.
Abidi I H, Khalid F A, Farooq M U, Hussain M A, Maqbool A. Tailoring the pore morphology of porous nitinol with suitable mechanical properties for biomedical applications. Materials Letters, 2015, 154, 17–20.
Yablokova G, Speirs M, Van Humbeeck J, Kruth J-P, Schrooten J, Cloots R, Boschini F, Lumay G, Luyten J. Rheological behavior of ß-Ti and NiTi powders produced by atomization for SLM production of open porous orthopedic implants. Powder Technology, 2015, 283, 199–209.
Zhu S L, Yang X J, Hu F, Deng S H, Cui Z D. Processing of porous TiNi shape memory alloy from elemental powders by Ar-sintering. Materials Letters, 2004, 58, 2369–2373.
Zhu S L, Yang X J, Fu D H, Zhang L Y, Li C Y, Cui Z D. Stress-strain behavior of porous NiTi alloys prepared by powders sintering. Materials Science and Engineering A, 2005, 408, 264–268.
Yuan B, Zhu M, Gao Y, Li X, Chung C Y. Forming and control of pores by capsule-free hot isostatic pressing in NiTi shape memory alloys. Smart Materials and Structures, 2008, 17, 025013.
Li H, Yuan B, Gao Y, Chung C Y, Zhu M. High-porosity NiTi superelastic alloys fabricated by low-pressure sintering using titanium hydride as pore-forming agent. Journal of Materials Science, 2009, 44, 875–881.
Yuan B, Li H, Gao Y, Chung C Y, Zhu M. Passivation and oxygen ion implantation double surface treatment on porous NiTi shape memory alloys and its Ni suppression performance. Surface and Coatings Technology, 2009, 204, 58–63.
Yuan B, Lai M, Gao Y, Chung C Y, Zhu M. The effect of pore characteristics on Ni suppression of porous NiTi shape memory alloys modified by surface treatment. Thin Solid Films, 2011, 519, 5297–5301.
Li H, Yuan B, Gao Y, Chung C Y, Zhu M. Remarkable biocompatibility enhancement of porous NiTi alloys by a new surface modification approach: In-situ nitriding and in vitro and in vivo evaluation. Journal of Biomedical Materials Research Part A, 2011, 99A, 544–553.
Yuan B, Li H, Gao Y, Zeng M Q, Zhu M. A Method of Fabricating Superelastic Gradient Porosity NiTi Shape Memory Alloys, China Patent No. ZL201010104527.0.
Gao Y, Zhou D, Yuan B, Zhu M. Mould Design for Green Sample of Graded Porosity NiTi Shape Memory Alloys Simulating Long Bone Structure, China Patent No. ZL201210562704.9.
Ismail M H, Goodall R, Davies H A, Todd I. Porous NiTi alloy by metal injection moulding/sintering of elemental powders: Effect of sintering temperature. Materials Letters, 2012, 70, 142–145.
Gibson L J. The mechanical behavior of cancellous bone. Journal of Biomechanics, 1985, 18, 317–328.
Wang X J, Li Y C, Hodgson P D, Wen C E. Nano- and macro-scale characterization of the mechanical properties of bovine bone. Materials Forum, 2007, 31, 156–159.
Karageorgiou V, Kaplan D. Porositsy of 3D biomaterial scaffolds and osteogenesis. Biomaterials, 2005, 26, 5474–5491.
Bansiddhi A, Dunand D C. Shape-memory NiTi foams produced by replication of NaCl space-holders. Acta Bio-materialia, 2008, 4, 1996–2007.
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Zhou, D., Gao, Y., Lai, M. et al. Fabrication of NiTi Shape Memory Alloys with Graded Porosity to Imitate Human Long-bone Structure. J Bionic Eng 12, 575–582 (2015). https://doi.org/10.1016/S1672-6529(14)60147-5
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DOI: https://doi.org/10.1016/S1672-6529(14)60147-5