Abstract
This review discusses recent studies on dendrimer- based nanoparticles in cancer chemotherapy and gene therapy. In order to achieve the high efficacy and low side effects of chemotherapy and gene therapy, it is essential to combine the unique features of dendrimers and the specific tumor microenvironment to target delivery and control release of therapeutic agents to tumor tissues and cells. Strategies to design the dendrimer-based delivery system in this review include non-modified dendrimers, dendrimer conjugates, assembled amphiphilic dendrimers, nanohybrid dendrimer carriers and dendrimers with inherent activity. In addition, specific functional groups on these dendrimers as stimuli-responsive system for targeting delivery and controlled release of therapeutic agents are discussed.
摘要
针对肿瘤组织的微环境, 结合树状大分子的特点可以构建定向可控药物、基因传递系统, 实现化学或基因治疗中的高效低毒. 本综 述从树状大分子的结构出发, 总结了其纳米载体在肿瘤治疗中的最新进展, 尤其重点讨论了传统树状大分子、树状大分子偶联物、可自 组装的两亲性树状大分子、杂化树状大分子及自身具有药理活性的树状大分子作为药物或基因递送载体的应用. 我们希望本综述将有助 于启发未来的相关研究, 以进一步拓展这种材料在肿瘤治疗中的新应用.
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Acknowledgements
This work was supported by the National Natural Science Foundation of China (81601594, 51690153, 21474045 and 21720102005).
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Lei Jiang is an assistant porfessor of the School of Pharmacy in China Pharmaceutical University. She received her PhD degree from Shenyang Pharmaceutical University. She was a postdoctoral fellow at MOE Key Laboratory of High Performance Polymer Materials and Technology, and the Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering in Nanjing University.
Sensen Zhou received his BSc degree in polymer science and engineering from Heifei University of Technology in 2015. Now, he is a PhD candidate at Nanjing University. His current research interests include the design of biomaterials in drug delivery and bioimaging.
Xiqun Jiang is a professor of MOE Key Laboratory of High Performance Polymer Materials and Technology, and the Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering in Nanjing University. He is the winner of the National Science Foundation for Distinguished Young Scholars of China.
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Jiang, L., Zhou, S., Zhang, X. et al. Dendrimer-based nanoparticles in cancer chemotherapy and gene therapy. Sci. China Mater. 61, 1404–1419 (2018). https://doi.org/10.1007/s40843-018-9242-3
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DOI: https://doi.org/10.1007/s40843-018-9242-3