Abstract
A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP) calcium channel antagonists felodipine, nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde, methyl acetoacetate and ethyl 3-aminocrotonate was developed. Operational simplicity, mild reaction conditions and eco-friendliness are the key features of this protocol.
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Supported by the National Natural Science Foundation of China(No. 21706236), the China Postdoctoral Science Foundation (No. 2016M592012) and the Foundation for Selected Postdoctoral Project of Zhejiang Province, China(No. BSH1502150).
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Application of enzymatic promiscuity in pharmaceutical synthesis: papain-catalyzed one-pot synthesis of 1,4-dihydropyridine calcium channel antagonists and derivatives
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Jiang, L., Ye, W., Su, W. et al. Application of Enzymatic Promiscuity in Pharmaceutical Synthesis: Papain-catalyzed One-pot Synthesis of 1,4-Dihydropyridine Calcium Channel Antagonists and Derivatives. Chem. Res. Chin. Univ. 35, 21–25 (2019). https://doi.org/10.1007/s40242-019-8273-8
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DOI: https://doi.org/10.1007/s40242-019-8273-8