Abstract
In this paper, a novel bismuthoxide Schiff-base complex [Bi9O8(vanen)3(NO3)2(CH3OH)2(H2O)·3NO3·5.5H2O](abbreviated as Bivanen) was synthesized with Salen-like ligand[H2vanen=N,N’-ethylene bis(3-methoxy-salicylideneimine)] and bismuth(III) nitrate. Its structure was characterized by IR spectra, NMR spectra and X-ray diffraction. In particular, the biology activities of the ligand and the complex against Schizosaccharomyces pombe (S. pombe) were studied using biological microcalorimetry. The metabolic thermogenic curves of S. pombe were measured at 32.00 °C. Then, some quantitative thermokinetic parameters of growth metabolism of S. pombe including the rate constant(k), inhibition ratio(I) and half inhibition concentration(IC50) were calculated. Experimental results showed that the k values of S. pombe decreased while I values of S. pombe increased with the increase of concentrations of the ligand and the complex. The IC50 of the ligand and the complex were found to be 0.067 and 0.037 mmol/L, respectively.
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Supported by the National Natural Science Foundation of China(Nos. 21273190, 20973145) and the Science and Technology Plan Projects of Hunan Province, China(Nos. 2014FJ3011, 2013FJ3033, 2014TT2026).
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Li, C., Jiang, J., Li, X. et al. Synthesis and bioactivity of a novel bismuthoxide Schiff-base complex derived from Salen-like ligand and bismuth(III) nitrate. Chem. Res. Chin. Univ. 32, 207–211 (2016). https://doi.org/10.1007/s40242-016-5350-0
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DOI: https://doi.org/10.1007/s40242-016-5350-0