Abstract
A convenient and efficient method was developed for the synthesis of naphtho[2,1-b]furans via 4-dimethylaminopyridine(DMAP)-catalyzed cascade reaction of 2-hydroxy-1-naphthaldehydes and α-halogenated ketones in moderate to good yields in the presence of Na2CO3 at 80 ºC for 6 h. The mechanism for this process was briefly discussed with a tentative catalytic cycle proposed. Moreover, this method features organocatalysts and high step-economy, which make it practical and attractive.
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Supported by the National Natural Science Foundation of China (Nos.21172001, 21372008), the Program for the New Century Excellent Talents in University of China(No.NCET-10-0004) and the Natural Science Foundation of Anhui Province of China(No.1308085QB39).
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Fan, C., He, X., Liao, K. et al. 4-dimethylaminopyridine-catalyzed cascade reaction for efficient synthesis of naphthofurans. Chem. Res. Chin. Univ. 32, 62–67 (2016). https://doi.org/10.1007/s40242-016-5245-0
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DOI: https://doi.org/10.1007/s40242-016-5245-0