Abstract
Diastereoselective tandem N-alkylation/homo- and cross-addition reactions of \(\alpha \)-aldimino thioesters were developed to give anti-1,2-diamine products in good to high yields. Furthermore, the synthesis of anti-3-amino \(\beta \)-lactam was also developed via N-alkylation/cross-addition/cyclization reaction.
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This work was supported by Grants-in-Aid for Scientific Research (B) and on Innovative Areas “Organic Synthesis Based on Reaction Integration, Development of New Methods and Creation of New Substances” from JSPS and MEXT.
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Dedicated to Professor Teruaki Mukaiyama in celebration of his 90th birthday (Sotsuju).
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Mizota, I., Nakajima, Y., Higashino, A. et al. Synthesis of 1,2-Diamino Acid Derivatives Utilizing Diastereoselective Tandem N-Alkylation/Homo- and Cross-Addition Reaction of \(\alpha \)-Aldimino Thioesters. Arab J Sci Eng 42, 4249–4261 (2017). https://doi.org/10.1007/s13369-017-2615-y
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DOI: https://doi.org/10.1007/s13369-017-2615-y