Abstract
Objectives
To investigate clinical characteristics and risk factors for atypical community-acquired pneumonia (CAP) in children.
Methods
Multiplex polymerase chain reaction and specific IgM determination were used to detect atypical bacteria in 661 hospitalized children aged 1–15 years with CAP. Clinical and epidemiological patterns were compared between typical and atypical CAP.
Results
Children in atypical CAP group manifested significantly lower rates of wheezing, bronchial rales, and interstitial pneumonia and showed higher rates of asthma history, headache, chest pain, and lobar pneumonia. Age group, season of disease onset, asthma history, duration of symptom onset to hospital admission, and radiological findings were the significant risk factors for atypical CAP on multivariate logistic regression analysis.
Conclusions
The clinical characteristics and risk factors can be used to identify a child at high risk of atypical CAP.
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Acknowledgements
Prof. Nguyen Thanh Liem — Former Director of the Vietnam National Children’s Hospital for helpfully supporting the study, Ms. Do Thi Bich Ngoc and to our colleagues at National Institute of Hygiene & Epidemiology and Vietnam National Children’s Hospital for technical help.
Funding
Funding: National Foundation for Science and Technology Development (NAFOSTED), grant no. 106.03-2010.36 from The Ministry of Science and Technology, Vietnam. Competing interest: None stated.
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Contributions
PLTH: conceptualized and designed the study, designed and performed laboratory analyses, drafted the initial manuscript, reviewed and revised the manuscript; PTH: recruited patients, collected and entered data, follow-up patients; NTPL: participated in laboratory analyses, reviewed the manuscript; DMT: designed the study, recruited patients, follow-up patients, participated in discussion and interpretation of the findings; DDA: had a substantial contribution in experimental design and interpretation of ELISA and multiplex PCR, critically reviewed the manuscript; TQB: cleaned data, supervised data collection, performed statistical analyses and interpretation of findings, critically reviewed and revised the manuscript. All authors read and approved the final manuscript.
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Research Ethics Committee Vietnam National Children’s Hospital; No. 1124/HDDD, dated 2 June, 2010.
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Huong, P.L.T., Hien, P.T., Lan, N.T.P. et al. Clinical Patterns and Risk Factors for Pneumonia Caused by Atypical Bacteria in Vietnamese Children. Indian Pediatr 58, 1056–1058 (2021). https://doi.org/10.1007/s13312-021-2373-5
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DOI: https://doi.org/10.1007/s13312-021-2373-5