Abstract
Objectives
To study the vaccine-induced measles specific immunoglobulin G (IgG) response in children aged 4–12 years immunized with two doses of measles containing vaccine in infancy.
Methods
This cross-sectional study was done in a tertiary care centre for a period of 18 months from January, 2017. Measles specific IgG levels were assessed using ELISA technique in 80 children of age 4–12 years, [mean (SD) age, 7.5 (2065)] who had received two doses of measles vaccine in infancy. Measles-specific IgG levels >11 NTU were considered protective.
Results
Protective levels of measles specific IgG were found in 86.4%. Significant association was found between negative immune response to measles vaccine and low socioeconomic status (P=0.03), under-nutrition (P=0.001), anemia (P=0.03), lack of exclusive breast feeding till 5 months of age (P=0.007) and higher parity (P=0.002).
Conclusion
Less than one-seventh of children immunized with two doses of measles vaccine in infancy had measles-specific IgG below protective levels at the average age of 7.5 yr. Lack of exclusive breast feeding till 5 months of age, under-nutrition and anemia were the associated factors.
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Acknowledgements
Dr Sara Jones PhD, and Dr John B Johnson PhD, Scientists, Rajiv Gandhi Institute of Biotechnology, Thiruvananthapuram for their meticulous help and support for the study.
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Ethics clearance
Institutional ethics committee, Government Medical College, Thiruvananthapuram; No.01/26/2017/MCT dated January 6, 2017.
Contributors
LK: planned the study, literature search, involved in data collection and analysis, prepared the manuscript. AM: done the data collection, literature search and involved in data analysis.
Funding
None; Competing interests: None stated.
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Kumari, P.L., Kutty, A.M. Measles Specific Immunoglobulin G Response in Children Aged 4–12 Year Who Received Two Doses of Measles Containing Vaccine in Infancy. Indian Pediatr 58, 250–252 (2021). https://doi.org/10.1007/s13312-021-2165-y
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DOI: https://doi.org/10.1007/s13312-021-2165-y