Abstract
Background
Infantile choriocarcinoma is usually fatal without appropriate treatment.
Case characteristics
A 3-month-old boy who presented with respiratory distress, hepatomegaly, amemia and bilateral nodular lesions on chest X-ray.
Observation
Fine-needle liver aspiration revealed necrotic tumour cells. The serum β-hCG level was very high (2057 mIU/L), supporting a diagnosis of infantile choriocarcinoma of the liver. Surgical resection after cisplatin-based multiagent chemotherapy afforded successful remission.
Message
Early treatment of infantile choriocarcinoma can yield a successful outcome.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Frazier AL, Billmire D, Amatruda J. Pediatric Germ Cell Tumors. In: Orkin SH, Fisher DE, Ginsburg D, Look AT, Lux SE, Nathan DG, editors. Nathan and Oski’s Hematology and Oncology of Infancy and Childhood. 8th ed. Philadelphia: Elsevier Health Sciences. 2014. p. 2082.
Timothy B, Nolting L. Cutaneous manifestation of metastatic infantile choriocarcinoma. Case Rep Pediatr. 2014;2014:104652.
Hanson D, Walter AW, Dunn S, Rittenhouse DW, Griffin G. Infantile choriocarcinoma in a neonate with massive liver involvement cured with chemotherapy and liver transplant. J Pediatr Hematol Oncol. 2011;33:e258–60.
Blohm ME, Calaminus G, Gnekow AK, Heidemann PH, Bolkenius M, Weinel P, et al. Disseminated choriocarcinoma in infancy is curable by chemotherapy and delayed tumour resection. Eur J Cancer. 2001;37:72–8.
Kim SN, Chi JG, Kim YW, Dong ES, Shin HY, Ahn HS, et al. Neonatal choriocarcinoma of liver. Pediatr Pathol. 1993;13:723–30.
Szavay PO, Wermes C, Fuchs J, Schrappe M, Flemming P, von Schweinitz D. Effective treatment of infantile choriocarcinoma in the liver with chemotherapy and surgical resection: a case report. J Pediatr Surg. 2000;35: 1134–5.
Yoon JM, Burns RC, Malogolowkin MH, Mascarenhas L. Treatment of infantile choriocarcinoma of the liver. Pediatr Blood Cancer. 2007;49:99–102.
Blohm ME, Göbel U. Unexplained anaemia and failure to thrive as initial symptoms of infantile choriocarcinoma: a review. Eur J Pediatr. 2004;163:1–6.
Johnson EJ, Crofton PM, O’Neill JM, Wilkinson AG, McKenzie KJ, Munro FD, et al. Infantile choriocarcinoma treated with chemotherapy alone. Med Pediatr Oncol. 2003;41:550–7.
Heath JA, Tiedemann K. Successful management of neonatal choriocarcinoma. Med Pediatr Oncol. 2001;36:497–9.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kartal, I., Dagdemir, A., Elli, M. et al. Pulmonary Metastasis in Infantile Choriocarcinoma: Successful Outcome. Indian Pediatr 55, 699–700 (2018). https://doi.org/10.1007/s13312-018-1362-9
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13312-018-1362-9