Abstract
Summary
Mesoporous silica nanoparticles (MSNs) are fascinating due to their interesting properties and applications.
Purpose
The optimization of MSNs for drug delivery applications was achieved by preparing different formulations of MSNs using different concentrations of ammonium hydroxide (NH4OH) (0.7, 1.4, 2.8, 4.2, and 5.6 mg/ml for MSN1, MSN2, MSN3, MSN4, and MSN5, respectively).
Methods
In the synthesis of MSNs, NH4OH was used as a catalyst while tetraethyl orthosilicate were used as a source of silica. Transmission electron microscopy (TEM) image revealed a linear increase in the size of the formed MSNs with increase in catalyst concentration. TEM images showed that all investigated nanoparticles were dispersed and spherical (changed to oval on addition of higher concentration of NH4OH).
Results
The hydrodynamic sizes of prepared MSNs were (64.18 ± 6.8, 90.46 ± 7.1, 118.98 ± 7.01, 152.7 ± 1.7, and 173.9 ± 9.36 nm for MSN1, MSN2, MSN3, MSN4, and MSN5, respectively) assessed using the dynamic light scattering (DLS) technique. The negative values of zeta potential indicated high surface stability of the formed MSNs. N2-isotherm revealed that the pore volume of MSNs decreased with increase in the size of MSNs. In vitro drug release showed that all MSNs exhibited high encapsulation efficiency of doxorubicin. The encapsulation efficiency were 92.2%, 82.8%, 72.2%, 72.1% and 71.9%for MSN1, MSN2, MSN3, MSN4, and MSN5, respectively.
Conclusion
MSN1 and MSN2, with sizes of 64.18 ± 6.8 and 90.46 ± 7.1 nm, pore volume of 0.89 and 0.356 cc/g, encapsulation efficiency of 92.2% and 82.8%, and adequate drug release profiles, were probably the best choices for a drug carrier in drug delivery applications.
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Data Availability
All data generated or analyzed during this study are included in this published article (the raw data will be available in case required them from the authors).
References
Samir A, Elgamal BM, Gabr H, Sabaawy HE (2015) Nanotechnology applications in hematological malignancies. Oncol Rep 34(3):1097–1105
dos Santos SN, Dos Reis SRR, Pires LP, Helal-Neto E, Sancenón F, Barja-Fidalgo TC, Santos-Oliveira R (2017) Avoiding the mononuclear phagocyte system using human albumin for mesoporous silica nanoparticle system. Microporous Mesoporous Mater 251:181–189
McMillan J, Batrakova E, Gendelman HE (2011) Chap. 14. Cell delivery of therapeutic nanoparticles. In: Progress in Molecular Biology and Translational Science 104, 563–601. Academic, Cambridge
Vallet-Regí M, Colilla M, Izquierdo-Barba I, Manzano M (2018) Mesoporous silica nanoparticles for drug delivery: current insights. Molecules 23(1):47
Skibińska M, Pikus S (2017) Small-angle X-ray scattering (SAXS) studies of the structure of mesoporous silicas. Nucl Instrum Methods Phys Res Sect B 411:72–77
Kent N, Nigra MM, Coppens MO (2017) Effect of stirring rate on the morphology of FDU-12 mesoporous silica particles. Microporous Mesoporous Mater 249:61–66
Marin R, Freris I, Marchiori M, Moretti E, Storaro L, Canton P, Lausi A, Benedetti A, Riello P (2014) Mesoporous silica nanoparticles with tunable pore size for tailored gold nanoparticles. J Nanopart Res 16:2245
Lee N, Kim T, Kim J, Hyeon T (2011) Multifunctional mesoporous silica nanocomposite nanoparticles for theranostic applications. Acc Chem Res 44:893–902
Martín-Saavedra E, Ruíz-Hernández A, Boré D, Arcos M, Vallet-Regí N, Vilaboa, (2010) Magnetic mesoporous silica spheres for hyperthermia therapy. Acta Biomater 6(12):4522–4531
Ji Q, Mori T, Naito M, Yamauchi Y, Abe H (2013) Hill, Enzyme nanoarchitectonics: organization and device application. Chem Soc Rev 42:6322–6345
Slowing II, Trewyn BG, Giri S, Lin VY (2007) Mesoporous silica nanoparticles for drug delivery and biosensing applications. Adv Funct Mater 17(8):1225–1236
Egodawatte S, Kaplan DI, Larsen SC, Serkiz SM, Seaman JC (2016) Functionalized magnetic mesoporous silica nanoparticles for U removal from low and high pH groundwater. J Hazard Mater 317:494–502
Mizoshita N, Tanaka H (2017) Interface-assisted synthesis of mesoporous silica nanoparticles using neat tetraalkoxysilanes. Microporous Mesoporous Mater 239:1–8
Vivero-Escoto J, Slowing II, Garrone E, Onida B, Lin VSY (2009) Cell-induced intracellular controlled release of membrane impermeable cysteine from a mesoporous silica nanoparticle-based drug delivery system. Chem Commun 22:3219–3221
Kim S, Park C, Lee H, Park HJ, Kim C (2010) Glutathione-induced intracellular release of guests from mesoporous silica nanocontainers with cyclodextrin gatekeepers. Adv Mater 22:4280–4283
Kulanthaivel S, Mondal A, Mishra S, Banerjee B, Bhaumik A, Giri S (2017) Mesoporous silica nanoparticle based enzyme responsive system for colon specific drug delivery through guar gum capping. Colloids Surf B 150:352–361
Cote MF, -Gaudreault RC, Fortin MA, Kleitz F (2016) Size-controlled functionalized mesoporous silica nanoparticles for tunable drug release and enhanced anti-tumoral activity. Chem Mater 28:4243–4258
Cendrowski K, Barylak M, Roginska D, Tarnowski M, Tkacz M, Kurzawski M, Machalinski B, Mijowska E, Drozdzik M (2015) Study on size effect of the silica nanospheres with solid core and mesoporous shell on cellular uptake. Biomed Mater 10:065012
Nienhaus K, Nienhaus GU (2014) Engineered nanoparticles interacting with cells: size matters. J Nanobiotechnol 12:5
Gabrielsson S, Strømme M, Scheynius A, Garcia-Bennett AE (2007) Mesoporous silica particles induce size dependent effects on human dendritic cells. Nano Lett 7:3576–3582
Labhasetwar V, Walter E, Levy RJ, Amidon GL (1997) The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent. Pharm Res 14:1568–1573
Sahar MR, Ghoshal SK, Arifin R, Rohani MS, Hamzah K, Jandra M (2013) Natural Fe3O4 nanoparticles embedded zinc–tellurite glasses: Polarizability and optical properties. Mater Chem Phys 138:174–178
Tong L, Ren X, Li Q, Ding H, Yang H (2013) Bifunctional Fe3O4@ C/YVO4: Sm3 + composites with the core–shell structure. Mater Chem Phys 139:73–78
Yanagisawa T, Shimizu T, Kuroda K, Kato C (1990) The preparation of alkyltriinethylaininonium–kaneinite complexes and their conversion to microporous materials. Bull Chem Soc Jpn 63(4):988–992
Kresge CT, Leonowicz ME, Roth WJ, Vartuli JC, Beck JS (1992) Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism. Nature 359(6397):710
Burkett SL, Davis SA, Fowler CE, Mendelson NH, Sims SD, Walsh D (1997) Whilton. Sol – gel synthesis of organized matter. Chem Mater 9:2300–2310
Hoffmann F, Cornelius M, Morell J, Fröba M (2006) Silica-based mesoporous organic–inorganic hybrid materials. Angew Chem Int Ed 45(20):3216–3251
Huang Q, Li C, Bao C, Liu Z, Li F, Zhu L (2010) Anticancer drug release from a mesoporous silica based nanophotocage regulated by either a one-or two-photon process. J Am Chem Soc 132:10645–10647
Lin CL, Haynes (2010) Impacts of mesoporous silica nanoparticle size, pore ordering, and pore integrity on hemolytic activity. J Am Chem Soc 132:4834–4842
Asaro F, Benedetti A, Freris I, Riello P, Savko N (2010) Evolution of the nonionic inverse microemulsion – acid – TEOS system during the synthesis of nanosized silica via the sol – gel process. Langmuir 26(15):12917–12925
Argyo C, Bein T (2010) Impact of different PEGylation patterns on the long-term bio-stability of colloidal mesoporous silica nanoparticles. J Mater Chem 20:8693–8699
Shi J (2011) Mesoporous silica nanoparticle based nano drug delivery systems: synthesis, controlled drug release and delivery. pharmacokinetics and biocompatibility. J Mater Chem 21:5845–5855
Wang JG, Sun PC, Ding DT, Chen TH (2009) Effect of alcohol on morphology and mesostructure control of anionic-surfactant-templated mesoporous silica (AMS). J Colloid Interface Sci 331:156–162
Han BH, Yang Y (2004) Simple synthesis route to monodispersed SBA-15 silica rods. J Am Chem Soc 126:14348–14349
Fan J, Tian B, Zhao D (2004) Morphology development of mesoporous materials: a colloidal phase separation mechanism. Chem Mater 16:889–898
Hwang YK, Chang JS, Kwon YU, Park SE (2004) Microwave synthesis of cubic mesoporous silica SBA-16. Microporous Mesoporous Mater 68(1–3):21–27
Dos Reis TVS, Cosentino IC, Fantini MCDA, Matos JR, Bruns RE (2010) Factorial design to optimize microwave-assisted synthesis of FDU-1 silica with a new triblock copolymer. Microporous Mesoporous Mater 133:1–9
Yan X, Kruk M (2010) Synthesis of ultralarge-pore FDU-12 silica with face-centered cubic structure. Langmuir 26:14871–14878
Kruk M (2015) Versatile surfactant/swelling-agent template for synthesis of large-pore ordered mesoporous silicas and related hollow nanoparticles. Chem Mater 27:679–689
Nooney RI, Thirunavukkarasu D, Chen Y, Josephs R, Ostafin AE (2002) Synthesis of nanoscale mesoporous silica spheres with controlled particle size. Chem Mater 14(11):4721–4728
Vazquez NI, Gonzalez Z, Ferrari B, Castro Y (2017) Synthesis of mesoporous silica nanoparticles by sol–gel as nanocontainer for future drug delivery applications. Bol Soc Esp Cerám Vidr 56(3):139–145
Guo X, Gao K, Gutsche A, Seipenbusch M, Nirschl H (2015) Combined small-and wide-angle X-ray scattering studies on oxide-supported Pt nanoparticles prepared by a CVS and CVD process. Powder Technol 272:23–33
Akiba I, Harrisson S, Wooley KL (2008) Facile formation of uniform shell-crosslinked nanoparticles with built‐in functionalities from N‐hydroxysuccinimide‐activated amphiphilic block copolymers. Adv Funct Mater 18:551–559
Rao SN, Fitzmaurice D (2000) Characterization of protein aggregated gold nanocrystals. J Phys Chem B 104:4765–4776
Lin JS, Lam YF, Hu MC, Schaefer DW, Harris MT (2003) Size, volume fraction, and nucleation of Stober silica nanoparticles. J Colloid Interface Sci 266:346–358
Shaw S, Benning LG (2009) Quantification of initial steps of nucleation and growth of silica nanoparticles: An in-situ SAXS and DLS study. Geochim Cosmochim Acta 73(18):5377–5393
Feichtenschlager B, Kickelbick G, Peterlik H (2012) Effect of interparticle interactions on size determination of zirconia and silica based systems–A comparison of SAXS, DLS, BET, XRD and TEM. Chem Phys Lett 521:91–97
Chen H, He J, Tang H, Yan C (2008) Porous silica nanocapsules and nanospheres: dynamic self-assembly synthesis and application in controlled release. Chem Mater 20(18):5894–5900
Deodhar GV, Adams ML, Trewyn BG (2017) Controlled release and intracellular protein delivery from mesoporous silica nanoparticles. Biotechnol J 12(11):600408
Mou CY, Lin HP (2013) Synthesis of mesoporous silica nanoparticles. Chem Soc Rev 42:3862–3875
Cui Y, Dong H, Cai X, Wang D, Li Y (2012) Mesoporous silica nanoparticles capped with disulfide-linked PEG gatekeepers for glutathione-mediated controlled release. ACS Appl Mater Interfaces 4(6):3177–3183
Zhang Z, Mayoral A, Melián-Cabrera I (2016) Protocol optimization for the mild detemplation of mesoporous silica nanoparticles resulting in enhanced texture and colloidal stability. Microporous Mesoporous Mater 220:110–119
Lvov Y, Ariga K, Onda M, Ichinose I, Kunitake T (1997) Alternate assembly of ordered multilayers of SiO2 and other nanoparticles and polyions. Langmuir 13(23):6195–6203
Zhang Y, Wang J, Bai X, Jiang T, Zhang Q, Wang S (2012) Mesoporous silica nanoparticles for increasing the oral bioavailability and permeation of poorly water soluble drugs. Mol Pharm 9(3):505–513
Zhuravlev LT (2000) The surface chemistry of amorphous silica Zhuravlev model. Colloids Surf A: Physicochem Eng Asp 73(1–3):1–38
Bertholdo R, dos Reis FV, Pulcinelli SH, Santilli CV (2010) SAXS study of monodispersed silica nanospheres obtained by an amino acid route. J Non-Cryst Solids 356(44–49):2622–2625
Al-Attar L, Dyer A, Harjula R (2003) Uptake of radionuclides on microporous and layered ion exchange materials. J Mater Chem 13(12):2963–2968
Bore MT, Rathod SB, Ward TL, Datye AK (2003) Hexagonal mesostructure in powders produced by evaporation-induced self-assembly of aerosols from aqueous tetraethoxysilane solutions. Langmuir 19(2):256–264
Yu T, Malugin A, Ghandehari H (2011) Impact of silica nanoparticle design on cellular toxicity and hemolytic activity. ACS Nano 5(7):5717–5728
Wu SH, Lin YS, Hung Y, Chou YH, Hsu YH, Chang C, Mou CY (2008) Multifunctional mesoporous silica nanoparticles for intracellular labeling and animal magnetic resonance imaging studies. ChemBioChem 9(1):53–57
Huang X, Li L, Liu T, Hao N, Liu H, Chen D, Tang F (2011) The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in viv. ACS Nano 5(7):5390–5399
Prokop A, Davidson JM (2008) Nanovehicular intracellular delivery systems. J Pharm Sci 97(9):3518–3590
Vivero-Escoto JL, Slowing II, Trewyn BG, Lin VSY (2010) Mesoporous silica nanoparticles for intracellular controlled drug delivery. Small 6(18):1952–1967
Biswas AK, Islam MR, Choudhury ZS, Mostafa A, Kadir MF (2014) Nanotechnology based approaches in cancer therapeutics. Adv Nat Sci: Nanosci Nanotechnol 5(4):043001
Patel KD, Leong KW, Kim HW (2017) Progress in nanotheranostics based on mesoporous silica nanomaterial platforms. ACS Appl Mater Interfaces 9:10309–10337
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Mohamed M. Fathy, Wael M Elshemey and Heba Mohamed Fahmy conceived of the presented idea. Fatma M Yassin, Mohamed M. Fathy and Heba Mohamed Fahmy conceived and planned the experiments. Fatma M Yassin, Mohamed M. Fathy and Heba Mohamed Fahmy carried out the experiments. Fatma M Yassin contributed to samples characterizations. Fatma M Yassin, Wael M Elshemey, Heba Mohamed Fahmy and Mohamed Mahmoud Fathy contributed to the interpretation of the results. All authors contributed to the final version of the manuscript. All authors read and approved the manuscript and all data were generated in-house and that no paper mill was used.
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Fathy, M.M., Yassin, F.M., Elshemey, W.M. et al. Insight on the Dependence of the Drug Delivery Applications of Mesoporous Silica Nanoparticles on Their Physical Properties. Silicon 15, 61–70 (2023). https://doi.org/10.1007/s12633-022-01962-7
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DOI: https://doi.org/10.1007/s12633-022-01962-7