Abstract
In this study, we present the preparation of stable 1T-WS2 ultrathin nanosheets with NH +4 intercalation using a bottom-up hydrothermal method and the potential application of this material in light-induced photothermal cancer therapy. Our results revealed that nanosheets with a size of 150 nm were highly hydrophilic and exhibited strong light absorption and excellent photostability in the broad near-infrared wavelength region. The in vitro experimental results indicated good biocompatibility of the nanosheets. More notably, our in vivo antitumor experiments illustrated that light-induced photothermal ablation originating from irradiation of the 1T-WS2 nanosheets with an 808 nm laser could efficiently kill tumor cells; these effects were obtained not only at the cellular level but also in the living organs of mice. This result may lead to new applications of two-dimensional layered materials in novel photothermal therapies and other photothermal related fields.
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Jöbsis-vander Vliet, F. F. Discovery of the near-infrared window into the body and the early development of nearinfrared spectroscopy. J. Biomed. Opt. 1999, 4, 392–396.
Huang, X. H.; El-Sayed, I. H.; Qian, W.; El-Sayed, M. A. Cancer cell imaging and photothermal therapy in the nearinfrared region by using gold nanorods. J. Am. Chem. Soc. 2006, 128, 2115–2120.
Tang, S. H.; Chen, M.; Zheng, N. F. Sub-10-nm Pd nanosheets with renal clearance for efficient near-infrared photothermal cancer therapy. Small 2014, 10, 3139–3144.
Wang, S. T.; Chen, K. J.; Wu, T. H.; Wang, H.; Lin, W. Y.; Ohashi, M.; Chiou, P. Y.; Tseng, H. R. Photothermal effects of supramolecularly assembled gold nanoparticles for the targeted treatment of cancer cells. Angew. Chem., Int. Ed. 2010, 49, 3777–3781.
Wang, J.; Zhu, G. Z.; You, M. X.; Song, E. Q.; Shukoor, M. I.; Zhang, K. J.; Altman, M. B.; Chen, Y.; Zhu, Z.; Huang, C. Z.; Tan, W. H. Assembly of aptamer switch probes and photosensitizer on gold nanorods for targeted photothermal and photodynamic cancer therapy. ACS Nano 2012, 6, 5070–5077.
Ke, H. T.; Wang, J. R.; Dai, Z. F.; Jin, Y. S.; Qu, E. Z.; Xing, Z. W.; Guo, C. X.; Yue, X. L.; Liu, J. B. Gold-nanoshelled microcapsules: A theranostic agent for ultrasound contrast imaging and photothermal therapy. Angew. Chem., Int. Ed. 2011, 50, 3017–3021.
You, J.; Zhang, G. D.; Li, C. Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release. ACS Nano 2010, 4, 1033–1041.
Yavuz, M. S.; Cheng, Y. Y.; Chen, J. Y.; Cobley, C. M.; Zhang, Q.; Rycenga, M.; Xie, J. W.; Kim, C.; Song, K. H.; Schwartz, A. G. et al. Gold nanocages covered by smart polymers for controlled release with near-infrared light. Nat. Mater. 2009, 8, 935–939.
Ye, E. Y.; Win, K. Y.; Tan, H. R.; Lin, M.; Teng, C. P.; Mlayah, A.; Han, M. Y. Plasmonic gold nanocrosses with multidirectional excitation and strong photothermal effect. J. Am. Chem. Soc. 2011, 133, 8506–8509.
Yuan, H.; Fales, A. M.; Vo-Dinh, T. TAT peptidefunctionalized gold nanostars: Enhanced intracellular delivery and efficient NIR photothermal therapy using ultralow irradiance. J. Am. Chem. Soc. 2012, 134, 11358–11361.
Terentyuk, G.; Panfilova, E.; Khanadeev, V.; Chumakov, D.; Genina, E.; Bashkatov, A.; Tuchin, V.; Bucharskaya, A.; Maslyakova, G.; Khlebtsov, N. et al. Gold nanorods with a hematoporphyrin-loaded silica shell for dual-modality photodynamic and photothermal treatment of tumors in vivo. Nano Res. 2014, 7, 325–337.
Liu, Y.; Yin, J.-J.; Nie, Z. H. Harnessing the collective properties of nanoparticle ensembles for cancer theranostics. Nano Res. 2014, 7, 1719–1730.
Kim, J. W.; Galanzha, E. I.; Shashkov, E. V.; Moon, H. M.; Zharov, V. P. Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents. Nat. Nanotechnol. 2009, 4, 688–694.
Wang, X. J.; Wang, C.; Cheng, L.; Lee, S.-T.; Liu, Z. Noble metal coated single-walled carbon nanotubes for applications in surface enhanced Raman scattering imaging and photothermal therapy. J. Am. Chem. Soc. 2012, 134, 7414–7422.
Hu, S.-H.; Chen, Y.-W.; Hung, W.-T.; Chen, I. W.; Chen, S.-Y. Quantum-dot-tagged reduced graphene oxide nanocomposites for bright fluorescence bioimaging and photothermal therapy monitored in situ. Adv. Mater. 2012, 24, 1748–1754.
Yu, J.; Javier, D.; Yaseen, M. A.; Nitin, N.; Richards- Kortum, R.; Anvari, B.; Wong, M. S. Self-assembly synthesis, tumor cell targeting, and photothermal capabilities of antibodycoated indocyanine green nanocapsules. J. Am. Chem. Soc. 2010, 132, 1929–1938.
Yang, J.; Choi, J.; Bang, D.; Kim, E.; Lim, E. K.; Park, H.; Suh, J. S.; Lee, K.; Yoo, K. H.; Kim, E. K. et al. Convertible organic nanoparticles for near-infrared photothermal ablation of cancer cells. Angew. Chem. 2011, 123, 461–464.
Song, X. J.; Chen, Q.; Liu, Z. Recent advances in the development of organic photothermal nano-agents. Nano Res. 2015, 8, 340–354.
Zhou, M.; Zhang, R.; Huang, M.; Lu, W.; Song, S. L.; Melancon, M. P.; Tian, M.; Liang, D.; Li, C. A chelator-free multifunctional [64Cu]CuS nanoparticle platform for simultaneous micro-PET/CT imaging and photothermal ablation therapy. J. Am. Chem. Soc. 2010, 132, 15351–5358.
Hessel, C. M.; Pattani, V. P.; Rasch, M.; Panthani, M. G.; Koo, B.; Tunnell, J. W.; Korgel, B. A. Copper selenide nanocrystals for photothermal therapy. Nano Lett. 2011, 11, 2560–2566.
Lakshmanan, S. B.; Zou, X. J.; Hossu, M.; Ma, L.; Yang, C.; Chen, W. Local field enhanced Au/CuS nanocomposites as efficient photothermal transducer agents for cancer treatment. J. Biomed. Nanotechnol. 2012, 8, 883–890.
Tian, Q. W.; Tang, M. H.; Sun, Y. G.; Zou, R. J.; Chen, Z. G.; Zhu, M. F.; Yang, S. P.; Wang, J. L.; Wang, J. H.; Hu, J. Q. Hydrophilic flower-like CuS superstructures as an efficient 980 nm laser-driven photothermal agent for ablation of cancer cells. Adv. Mater. 2011, 23, 3542–3547.
Tian, Q. W.; Jiang, F. R.; Zou, R. J.; Liu, Q.; Chen, Z. G.; Zhu, M. F.; Yang, S. P.; Wang, J. L.; Wang, J. H.; Hu, J. Q. Hydrophilic Cu9S5 nanocrystals: A photothermal agent with a 25.7% heat conversion efficiency for photothermal ablation of cancer cells in vivo. ACS Nano 2011, 5, 9761–9771.
Chen, Z. G.; Wang, Q.; Wang, H. L.; Zhang, L. S.; Song, G. S.; Song, L. L.; Hu, J. Q.; Wang, H. Z.; Liu, J. S.; Zhu, M. F. et al. Ultrathin PEGylated W18O49 nanowires as a new 980 nm-laser-driven photothermal agent for efficient ablation of cancer cells in vivo. Adv. Mater. 2013, 25, 2095–2100.
Chou, S. S.; Kaehr, B.; Kim, J.; Foley, B. M.; De, M.; Hopkins, P. E.; Huang, J. X.; Brinker, C. J.; Dravid, V. P. Chemically exfoliated MoS2 as near-infrared photothermal agents. Angew. Chem., Int. Ed. 2013, 52, 4160–4164.
Cheng, L.; Liu, J. J.; Gu, X.; Gong, H.; Shi, X. Z.; Liu, T.; Wang, C.; Wang, X. Y.; Liu, G.; Xing, H. Y. et al. PEGylated WS2 nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT/photoacoustic imaging guided photothermal therapy. Adv. Mater. 2014, 26, 1886–1893.
Liu, Q.; Sun, C. Y.; He, Q.; Liu, D. B.; Khalil, A.; Xiang, T. Wu, Z. Y.; Wang, J.; Song, L. Ultrathin carbon layer coated MoO2 nanoparticles for high-performance near-infrared photothermal cancer therapy. Chem. Commun. 2015, 51, 10054–10057.
Ohuchi, F. S.; Jaegermann, W.; Pettenkofer, C.; Parkinson, B. A. Semiconductor to metal transition of WS2 induced by K intercalation in ultrahigh vacuum. Langmuir 1989, 5, 439–442.
Zak, A.; Feldman, Y.; Lyakhovitskaya, V.; Leitus, G.; Popovitz-Biro, R.; Wachtel, E.; Cohen, H.; Reich, S.; Tenne, R. Alkali metal intercalated fullerene-like MS2 (M = W, Mo) nanoparticles and their properties. J. Am. Chem. Soc. 2002, 124, 4747–4758.
Yang, J.; Wang, H. Y.; Yi, W. J.; Gong, Y. H.; Zhou, X.; Zhuo, R. X.; Zhang, X. Z. PEGylated peptide based reductive polycations as efficient nonviral gene vectors. Adv. Healthcare Mater. 2013, 2, 481–489.
Liu, Q.; Li, X. L.; Xiao, Z. R.; Zhou, Y.; Chen, H. P.; Xiang, T.; Xu, J. Q.; Chu, W. S.; Wu, X. J.; Yang, J. L. et al. Stable metallic 1T-WS2 nanoribbons intercalated with ammonia ions: The correlation between structure and electrical/optical properties. Adv. Mater. 2015, 27, 4837–4844.
Voiry, D.; Yamaguchi, H.; Li, J. W.; Silva, R.; Alves, D. C. B.; Fujita, T.; Chen, M. W.; Asefa, T.; Shenoy, V. B.; Eda, G. et al. Enhanced catalytic activity in strained chemically exfoliated WS2 nanosheets for hydrogen evolution. Nat. Mater. 2013, 12, 850–855.
Timko, B. P.; Dvir, T.; Kohane, D. S. Remotely triggerable drug delivery systems. Adv. Mater. 2010, 22, 4925–4943.
Peng, C. L.; Shih, Y. H.; Lee, P. C. Hsieh, T. M. H.; Luo, T. Y.; Shieh, M. J. Multimodal image-guided photothermal therapy mediated by 188Re-labeled micelles containing a cyanine-type photosensitizer. ACS Nano 2011, 5, 5594–5607.
Zhang, J. L.; Jin, W.; Wang, X. Q.; Wang, J. C.; Zhang, X.; Zhang, Q. A novel octreotide modified lipid vesicle improved the anticancer efficacy of doxorubicin in somatostatin receptor 2 positive tumor models. Mol. Pharmaceutics 2010, 7, 1159–1168.
Yang, K.; Xu, H.; Cheng, L.; Sun, C. Y.; Wang, J.; Liu, Z. In vitro and in vivo near-infrared photothermal therapy of cancer using polypyrrole organic nanoparticles. Adv. Mater. 2012, 24, 5586–5592.
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Liu, Q., Sun, C., He, Q. et al. Stable metallic 1T-WS2 ultrathin nanosheets as a promising agent for near-infrared photothermal ablation cancer therapy. Nano Res. 8, 3982–3991 (2015). https://doi.org/10.1007/s12274-015-0901-0
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DOI: https://doi.org/10.1007/s12274-015-0901-0