Abstract
Molecular cell biology is overwhelmingly focused on a small number of organisms, most of which are found in a single taxonomic supergroup. Consequently, our knowledge of cellular biodiversity in terms of both behaviour and morphology is extremely limited. The African trypanosome, Trypanosoma brucei, is an outstanding laboratory organism, a causative agent of human and livestock disease, and a good example of the wealth of extreme cell biology that can be found in these more unexplored taxa.
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Flegontova O, Flegontov P, Malviya S et al. (2016) Extreme diversity of diplonemid eukaryotes in the ocean. Curr Biol 26:3060–3065
Nosala C, Hagen KD, Dawson SC (2018) ‘Disc-o-fever’: getting down with Giardia’s groovy microtubule organelle. Trends Cell Biol 28:99–112
Morriswood B, Engstler M (2017) Let’s get fISSical: fast in silico synchronization as a new tool for cell division cycle analysis. Parasitology 7:1–14
Overath P, Engstler M (2004) Endocytosis, membrane recycling and sorting of GPI-anchored proteins: Trypanosoma brucei as a model system. Mol Microbiol 53:735–744
Bartossek T, Jones NG, Schafer C et al. (2017) Structural basis for the shielding function of the dynamic trypanosome variant surface glycoprotein coat. Nat Microbiol 2:1523–1532
Goos C, Dejung M, Wehman AM et al. (2019) Trypanosomes can initiate nuclear export co-transcriptionally. Nucleic Acids Res 47:266–282
Engstler M, Pfohl T, Herminghaus S et al. (2007) Hydrodynamic flow-mediated protein sorting on the cell surface of trypanosomes. Cell 131:505–515
Bargul JL, Jung J, McOdimba FA et al. (2016) Species-specific adaptations of trypanosome morphology and motility to the mammalian host. PLoS Pathog 1212:e1005448
Schuster S, Kruger T, Subota I et al. (2017) Developmental adaptations of trypanosome motility to the tsetse fly host environments unravel a multifaceted in vivo microswimmer system. Elife 6, doi: https://doi.org/10.7554/eLife.27656
Zimmermann H, Subota I, Batram C et al. (2017) A quorum sensing-independent path to stumpy development in Trypanosoma brucei. PLoS Pathog 13:e1006324
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Brooke Morriswood 1998–2002 Biochemiestudium an der Universität Cambridge, UK. 2006 Promotion im Bereich Molekulare Zellbiologie bei Dr. J. Kendrick-Jones am Laboratory of Molecular Biology, Cambridge, UK. 2007–2014 Postdoc bei Prof. Dr. G. Warren an der Universität Yale, USA, und Max F. Perutz Laboratories, Wien, Österreich. Seit 2015 Nachwuchsgruppenleiter am Lehrstuhl für Zell und Entwicklungsbiologie, Universität Würzburg.
Markus Engstler 1986–1991 Biologiestudium an der Universität Kiel. 1994 Promotion in Biochemie. 1994-1998 Postdoc an der Rockefeller Universität, New York, USA, bei Prof. Dr. G. A. M. Cross und am Max-Planck-Institut für Biochemie in Martinsried bei Prof. Dr. M. Boshart. 1998–2001 Projektleiter an der FU Berlin. 2001–2004 Gruppenleiter an der LMU München. Dort 2004 Habilitation im Fach Genetik. 2006–2009 Professor am Institut für Genetik und Mikrobiologie der TU Darmstadt. Seit 2009 Professor und Leiter des Lehrstuhls Zell- und Entwicklungsbiologie am Biozentrum der Universität Würzburg.
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Morriswood, B., Engstler, M. Mehr Diversität für die Zellbiologie — Trypanosomen als Vorreiter. Biospektrum 25, 394–397 (2019). https://doi.org/10.1007/s12268-019-1068-0
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DOI: https://doi.org/10.1007/s12268-019-1068-0