Abstract
DNA and RNA — the nucleic acids within our cells — are more than information carrier in the flow of genetic information within biological systems. They fulfil very diverse functions in numerous cellular processes, such as the regulation of gene expression and cell signalling, they mediate protein interactions, control enzyme activity, can catalyse chemical reactions and are crucial for cellular immunity. Here, I discuss their multifaceted roles from a nucleic acids perspective.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Literatur
Harteis S, Schneider S (2014) Making the bend: DNA tertiary structure and protein-DNA interactions. Int J Mol Sci 15:12335–12363
Cech TR, Steitz JA (2014) The noncoding RNA revolution–trashing old rules to forge new ones. Cell 157:77–94
Storz G, Vogel J, Wassarman KM (2011) Regulation by small RNAs in bacteria: expanding frontiers. Mol Cell 43:880–891
Wilson RC, Doudna JA (2013) Molecular mechanisms of RNA interference. Annu Rev Biophys 42:217–239
Wang M, Yu F, Wu W et al. (2017) Circular RNAs: a novel type of non-coding RNA and their potential implications in antiviral immunity. Int J Biol Sci 13:1497–1506
Martin KC, Ephrussi A (2009) mRNA localization: gene expression in the spatial dimension. Cell 136:719–730
Loenen WA, Dryden DT, Raleigh EA et al. (2014) Highlights of the DNA cutters: a short history of the restriction enzymes. Nucleic Acids Res 42:3–19
Westra ER, Swarts DC, Staals RH et al. (2012) The CRISPRs, they are a-changin’: how prokaryotes generate adaptive immunity. Annu Rev Genet 46:311–339
Hartmann G (2017) Nucleic acid immunity. Adv Immunol 133:121–169
Shi Y (2017) The spliceosome: a protein-directed metalloribozyme. J Mol Biol 429:2640–2653
Jenni S, Ban N (2003) The chemistry of protein synthesis and voyage through the ribosomal tunnel. Curr Opin Struct Biol 13:212–219
Author information
Authors and Affiliations
Corresponding author
Additional information
Sabine Schneider 2007 Promotion an der University of Nottingham, UK. 2007–2010 Postdoktorandin an der LMU München. Seit 2010 unabhängige Forschungsgruppenleiterin an der TU München.
Rights and permissions
About this article
Cite this article
Schneider, S. DNA und RNA — mehr als nur Träger der genetischen Information. Biospektrum 24, 368–371 (2018). https://doi.org/10.1007/s12268-018-0930-9
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12268-018-0930-9