Abstract
In all living cells ribosomes are responsible for the translation of genetic information into the corresponding protein sequence. This central position does not only make them a valuable target for antibiotics but also offers great possibilities to regulate gene expression. This article addresses two distinct mechanisms of ribosomal activity regulation: via short nascent peptides (regulation in cis) and via proline-rich antimicrobial peptides (regulation in trans).
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A. Carolin Seefeldt Chemie- und Biochemiestudium an der LMU München. 2014 Masterarbeit bei Prof. Dr. D. N. Wilson. Seit 2014 Doktorandin in der Gruppe von Dr. C. Axel Innis am Institut Européen de Chimie et Biologie (IECB). Stipendiatin der Région Aquitaine und Inserm.
Britta Seip Biologiestudium (Diplom) an der Universität Bonn. 2010–2013 Doktorarbeit bei Prof. Dr. E. A. Galinski, 2012 Forschungsaufenthalt an der Yale University bei Prof. Dr. T. A. Steitz. Seit 2013 Postdoc in der Gruppe von Dr. C. Axel Innis am Institut Européen de Chimie et Biologie (IECB).
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Seefeldt, A.C., Seip, B. Kurze Peptide regulieren die Aktivität bakterieller Ribosomen. Biospektrum 23, 516–518 (2017). https://doi.org/10.1007/s12268-017-0833-1
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DOI: https://doi.org/10.1007/s12268-017-0833-1