Abstract
The first described non-coding RNAs (ncRNAs), microRNAs, regulate mRNA fate in a post-transcriptional manner. With the advent of modern high-throughput methods many novel classes of ncRNAs were described. In contrast to microRNAs, most of these regulate the transcription process itself and hence are of fundamental biological importance. Work in our laboratory addresses how transcriptional regulation by ncRNAs influences biological processes ranging from regeneration to neuronal plasticity.
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Elliott SA, Sánchez Alvarado A (2013) The history and enduring contributions of planarians to the study of animal regeneration. Wiley Interdiscip Rev Dev Biol 2:301–326
Reddien PW, Oviedo NJ, Jennings JR et al. (2005) SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells. Science 310:1327–1330
Czech B, Hannon GJ (2016) One loop to rule them all: the ping-pong cycle and piRNA-guided silencing. Trends Biochem Sci 41:324–337
Sienski G, Donertas D, Brennecke J (2012) Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression. Cell 151:964–980
Vourekas A, Alexiou P, Vrettos N et al. (2016) Sequence-dependent but not sequence-specific piRNA adhesion traps mRNAs to the germ plasm. Nature 531:390–394
De Santa F, Barozzi I, Mietton F et al. (2010) A large fraction of extragenic RNA pol II transcription sites overlap enhancers. PLoS Biol 8:e1000384
Kim TK, Hemberg M, Gray JM et al. (2010) Widespread transcription at neuronal activity-regulated enhancers. Nature 465:182–187
Sheng M, Greenberg ME (1990) The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 4:477–485
Schaukowitch K, Joo JY, Liu X et al. (2014) Enhancer RNA facilitates NELF release from immediate early genes. Mol Cell 56:29–42
Smola MJ, Rice GM, Busan S et al. (2015) Selective 2′-hydroxyl acylation analyzed by primer extension and mutational profiling (SHAPE-MaP) for direct, versatile and accurate RNA structure analysis. Nat Protoc 10:1643–1669
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Vladyslava Gorbovytska 2008–2013 Biochemiestudium (B. Sc.) an der Universität Bielefeld. 2013–2016 Studium der Biochemie und Molekularen Biologie (M. Sc.) an der Universität Bayreuth. Seit 2016 Doktorandin in der Arbeitsgruppe „Gene regulation by non-coding RNA“ innerhalb des Elitenetzwerks Bayern an der Universität Bayreuth.
Iana Kim 2005–2011 Biologiestudium (B. Sc. und M. Sc.) an der Universität Woronesch, Russische Föderation. 2011–2014 Forschungsassistentin an der Russischen Akademie der Wissenschaften in Moskau. Seit 2015 Doktorandin in der Arbeitsgruppe „Gene regulation by non-coding RNA“ innerhalb des Elitenetzwerks Bayern an der Universität Bayreuth.
Claus-D. Kuhn 1999–2003 Biochemiestudium an den Universitäten Regensburg und Stockholm, Schweden. 2003–2008 Doktorarbeit am Genzentrum der LMU München in der Arbeitsgruppe von Prof. Dr. P. Cramer. 2008–2014 Postdoc am Cold Spring Harbor Laboratory, New York, USA, in der Arbeitsgruppe von Prof. Dr. L. Joshua-Tor. Seit 2014 Gruppenleiter innerhalb des Elitenetzwerks Bayern an der Universität Bayreuth.
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Kim, I., Gorbovytska, V. & Kuhn, CD. Wie RNA die Genregulation beeinflusst. Biospektrum 23, 513–515 (2017). https://doi.org/10.1007/s12268-017-0832-2
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DOI: https://doi.org/10.1007/s12268-017-0832-2