Abstract
Bone morphogenetic proteins (BMPs) are crucial growth factors from embryonic development up to adult organ/tissue homeostasis since they regulate versatile processes such as stem cell maintenance, differentiation and migration. Aberrant signalling leads to pathologies including cancer or musculoskeletal and vascular diseases. Here, we provide an overview of the BMP signalling cascade and its complex regulation and show how we investigate this tightly controlled protein network in physiological and pathological model systems.
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Horbelt D, Denkis A, Knaus P (2012) A portrait of transforming growth factor ß superfamily signalling: background matters. Int J Biochem Cell Biol 44:469–474
Urist MR (1965) Bone: formation by autoinduction. Science 150:893–899
Wagner DO, Sieber C, Bhushan R et al. (2010) BMPs: from bone to body morphogenetic proteins. Sci Signal 3:mr1
Shore EM, Xu M, Feldman GJ et al. (2006) A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat Genet 38:525–527
Gordon KJ, Blobe GC (2008) Role of transforming growth factor-beta superfamily signaling pathways in human diseases. Biochim Biophys Acta 1782:197–228
Yadin D, Knaus P, Mueller TD (2016) Structural insights into BMP receptors: specificity, activation and inhibition. Cytokine Growth Factor Rev 27:13–34
Sieber C, Kopf J, Hiepen C et al. (2009) Recent advances in BMP receptor signaling. Cytokine Growth Factor Rev 20:343–355
Guzman A, Zelman-Femiak M, Boergermann JH et al. (2012) SMAD versus non-SMAD signaling is determined by lateral mobility of bone morphogenetic protein (BMP) receptors. J Biol Chem 287:39492–39504
Yamaguchi K, Nagai S, Ninomiya-Tsuji J et al. (1999) XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. EMBO J 18:179–187
Hiepen C, Benn A, Denkis A et al. (2014) BMP2-induced chemotaxis requires PI3K p55γ/p110a-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5ß recruitment at the cytocortex. BMC Biol 12:43
Kopf J, Petersen A, Duda GN et al. (2012) BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway. BMC Biol 10:37
Benn A, Bredow C, Casanova I et al. (2016) VE-Cadherin facilitates BMP-induced endothelial cell permeability and signaling. J Cell Sci 129:206–218
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Gina Dörpholz 2005–2011 Studium der Biowissenschaften und Biochemie, Universität Potsdam. 2012–2016 Promotion am Institut für Chemie und Biochemie, FU Berlin; dort seit 2016 Postdoc.
Patrizia Weigell 2009–2014 Studium der Biologie und Neurowissenschaften, Universität Regensburg. Seit 2014 Promotion am Institut für Chemie und Biochemie, FU Berlin.
Petra Knaus 1980–1986 Biologiestudium, Universität Heidelberg. 1986–1991 Promotion am Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH). 1991–1996 Postdoc am Whitehead Institute for Biomedical Research, MIT, Cambridge, USA. 1996–2002 Arbeitsgruppenleiterin und Habilitation am Institut für Physiologische Chemie II, Universität Würzburg, dort 2002–2004 Assistenzprofessur. Seit 2004 C3-Professur für Biochemie, FU Berlin. Seit 2007 W3-Professur für Biochemie und Molekulare Grundlagen der Regeneration, FU Berlin und Charité Berlin.
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Dörpholz, G., Weigell, P. & Knaus, P. BMP-Signaltransduktion – begleitet von control freaks und gate keepers . Biospektrum 22, 686–690 (2016). https://doi.org/10.1007/s12268-016-0743-7
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DOI: https://doi.org/10.1007/s12268-016-0743-7