Abstract
Certain yeasts produce toxins encoded by cytoplasmic killer plasmids and kill sibling cells which have lost the killer system. Those retaining it, survive due to an immunity gene. This selection regime is at risk when cytoplasmic DNA is captured in the nucleus, but the killer plasmids have prepared for this via an unusually high A/T bias. In case of nuclear immunity gene transcription, the polyadenylation system recognizes A/T-rich motifs, cleaves the mRNA and prevents immunity expression.
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Roland Klassen Jahrgang 1974. Biologiestudium an der Universität Münster; dort 2004 Promotion im Fach Mikrobiologie. 2005–2009 Postdoc in der Arbeitsgruppe von Prof. Dr. F. Meinhardt. 2009–2012 Postdoc und Staff Scientist an der University of Texas Medical Branch, Galveston, USA. Seit 2013 wissenschaftlicher Mitarbeiter und Habilitant im Fachgebiet Mikrobiologie an der Universität Kassel.
Raffael Schaffrath Jahrgang 1963. Biologiestudium an den Universitäten Bonn, Münster, Shillong (Indien) und Dundee (UK). 1995 Promotion am Leicester Biocenter, UK. 1996–1997 Feodor-Lynen Fellow der Alexander von Humboldt-Stiftung, Harvard Medical School Boston, MA, USA. 1997–2007 Leiter der Arbeitsgruppe Molekulare Genetik, Universität Halle/Saale. 2003 Habilitation im Fach Genetik. 2007–2010 Reader in Genetics, University of Leicester, UK. Seit 2011 Professor für Molekulare Mikrobiologie, Universität Kassel.
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Klassen, R., Schaffrath, R. Killerplasmid-codierte Ribotoxin-RNasen aus Hefen. Biospektrum 22, 16–18 (2016). https://doi.org/10.1007/s12268-016-0649-4
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DOI: https://doi.org/10.1007/s12268-016-0649-4