Abstract
The injection performance of a small volume of needle-free injection (up to 0.3 mL) has proven to be controllable and satisfactory in transdermal drug delivery. However, no comprehensive research on the behavior of larger volume injections with different requirements for clinical applications exists. This study aims to present the penetration characteristics of larger volume injections, including dynamic properties, dispersion pattern, and percent delivery. The researchers conduct impact and injection experiments with injection volumes from 0.1–1.0 mL, driving pressures of 0.5–1.75 MPa, and orifice diameters of 0.17–0.5 mm. This study uses high-speed photography and impact experiments to capture the dynamic properties of the liquid jet. The researchers observe the dispersion patterns of liquid penetration into the gels in the gel injection experiments and investigate the percentages of liquid delivered to the skin tissues in porcine tissues injection experiments. Moreover, this study uses the response surface methodology (RSM) to analyze the interactive effect between various injection parameters on the injection performance. Results describe the differences in penetration performance between larger volume injections and small volume injections, and the critical volume of the mentioned injections is approximately 0.6 mL.
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Abbreviations
- θ s :
-
Half angle of the view
- W s :
-
Width of the captured scope
- D s :
-
Distance between the injection experiments facility and the camera
- P max :
-
Axial pressure oscillation peak
- PD :
-
Percent delivery
- RSM:
-
Response surface methodology
- E0 :
-
Jet power at the nozzle exit
- P :
-
Liquid density
- V :
-
Injection volume
- T :
-
Injection duration
- D 0 :
-
Orifice diameter
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Acknowledgements
This work was supported by the National Key R&D Program of China [grant number: 2018YFC0808401]; the National Key Basic Research Program of China [grant number: 2014CB 239203]; the National Natural Science Foundation of China (NSFC) [grant number: 51474158].
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The authors declare no financial or non-financial interests that represent potential conflict of interests.
Dongping Zeng received his B.S. degree from Northwest Agriculture Forestry University, Xian, China, in 2016, and is now a Ph.D. candidate in School of Power and Mechanical Engineering, Wuhan University, Wuhan, China. He focuses on the mechanical principle and clinic application of needle-free jet injector.
Yong Kang received his B.S. and Ph.D. degrees from Chongqing University, China, in 2001 and 2006. He is now a Professor and the vice dean of the School of Mechanical Engineering, Wuhan University, Wuhan, China. His research interests include biomedical engineering, water-jet technology, and mining technology.
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Zeng, D., Wu, N., Qian, L. et al. Experimental investigation on penetration performance of larger volume needle-free injection device. J Mech Sci Technol 34, 3897–3909 (2020). https://doi.org/10.1007/s12206-020-0840-x
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DOI: https://doi.org/10.1007/s12206-020-0840-x