Abstract
The melanoma differentiation-associated gene-7(mda-7), IL-24, has the specific functions that induce cancer cell apoptosis without doing harm to normal cells. We systematically review the apoptotic signal pathways and their regulatory mechanisms induced by Ad.IL-24 and IL-24 in diverse cancer cells. IL-24 can participate in varied signal transduction pathways, including JAK, p38 MAPK, Wnt/β-catenin, JNK, ER stress and mitochondria-associated signal pathways. And we review five proteins interacting with IL-24, including Bip/GRP78, S1R, PKR, Beclin1 and soluble clusterin, which are relative to the tumor-specific effect of IL-24. It is speculated that ER stress, G-protein pathways and MAPK signal pathways may be the primary upstream effectors which activate the sequential downstream mediators resulting in apoptosis induced by IL-24 in tumor cells. Experimental results also show that IL-24 sensitizes cancer cells and indirectly promotes apoptosis rather than functions as a direct apoptosis inducer itself.
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Foundation item: Supported by the National Program on Key Basic Research Project (973 Program) (2012CB518900), the National Natural Science Foundation of China (31160240, 31260621), the 12th Five Years Key Programs for Science and Technology Development of China (2012ZX10002006), the Hangzhou Normal University Supporting Project (PE13002004042), and the Natural Science Foundation of China of Jiangxi(20114BAB204016)
Biography: LIU Huilin, female, Master candidate, research direction: molecular mechanism of hepatocellular carcinoma and liver senescence, gene therapy in hepatocellular carcinoma.
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Liu, H., Chen, J., Jiang, X. et al. Apoptotic signal pathways and regulatory mechanisms of cancer cells induced by IL-24. Wuhan Univ. J. Nat. Sci. 21, 519–530 (2016). https://doi.org/10.1007/s11859-016-1205-2
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DOI: https://doi.org/10.1007/s11859-016-1205-2