Abstract
Tinospora cordifolia (Guduchi or Gurjo), a herbaceous vine or climbing deciduous shrub, is consider as an important medicine in the Ayurvedic system of medication, which is available in India, China, Myanmar, Bangladesh and Srilanka. Menispermaceae is the family of this compound. T. cordifolia have a variety of properties to treat various ailments such as fevers, jaundice, diabetes, dysentery, urinary infections, and skin diseases. This compound has been subjected to many chemicals, pharmacological, pre-clinical, or clinical investigations and some new therapeutic potential effects have been indicated. This review aims to summarize the critical information concerning in areas of chemical constituents, chemical structure, and pharmacokinetic activities such as anti-diabetic, anticancer, immune-modulatory, antivirus (especially in silico study about COVID-19), antioxidant, antimicrobial, hepatoprotective and its effect on cardiovascular and neurological disorders as well as rheumatoid arthritis. This traditional herb needs more experimental study on the clinical, pre-clinical study, and clinical efficacy of these compounds for the prevention and treatment of COVID-19 and needs large-scale clinical studies to prove the clinical efficacy of this compound, especially in stress-related diseases and other neuronal disorders.
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Sinha K, Mishra NP, Singh J, Khanuja SP. Tinospora cordifolia (Guduchi), a reservoir plant for therapeutic applications: a review. Ind J Tradit Knowl 2004;3:257–270.
Bharathi C, Reddy AH, Nageswari G, Lakshmi BS, Soumya M, Vanisri DS, Venkatappa B. A review on medicinal properties of Tinospora cordifolia. Int J Res Rev 2018;7:585–598.
Upadhyay A, Kumar K, Kumar A, Mishra H. Tinospora cordifolia (Willd.) Hook. f. and Thoms (Guduchi)—validation of the Ayurvedic pharmacology through experimental and clinical studies. Int J Ayu Res 2010;1:112.
Jeyachandran R, Xavier TF, Anand SP. Antibacterial activity of stem extracts of Tinospora cordifolia (Willd) Hook. f & Thomson. Ancient Sci Life 2003;23:40.
Saha S, Ghosh S. Tinospora cordifolia: one plant, many roles. Ancient Sci Life 2012;4:151.
Gupta S, Singh, Ashwlayan VD. Pharmacological activity of Tiospora cordifolia. Pharmacologyonlin 2011;644–652.
Sharma P, Dwivedee BP, Bisht D, Dash AK, Kumar D. The chemical constituents and diverse pharmacological importance of Tinospora cordifolia. Heliyon 2019;5:e02437.
Bharathi C, Reddy AH, Nageswari G, Sri Laxmi B, Soumya M, Vanisri DS, et al. A review on medicinal properties of Tinospora cordifolia. Int J Sci Res Rev 2018;7:585–598.
Pathan A, Kamble A, Chowdhury S, Laware S. Sequential extraction, and quantification of Tinospora cordifolia leaf pigments and metabolites. Int J Curr Microbiol Appl Sci 2015;4:638–644.
Reddi KK, Tetali SD. Dry leaf extracts of Tinospora cordifolia (Willd.) Miers attenuate oxidative stress and inflammatory condition in human monocytic (THP-1) cells. Phytomedicine 2019;61:152831.
Sardhara RA, Gopal S. Qualitative phytochemical screening of different solvent extracts of Tinospora cordifolia stem and lantana camara flower. Int Res J Pharm Appl Sci 2013;3:210–213.
Kumar V, Singh S, Singh A, Dixit AK, Srivastava B, Sidhu GK, et al. Phytochemical, antioxidant, antimicrobial, and protein binding qualities of hydro-ethanolic extract of Tinospora cordifolia. J Biolog Active Prod Nature 2018;8:192–200.
Dhama K, Sachan S, Khandia R, Munjal A, MN Iqbal HK, Latheef S, et al. Medicinal and beneficial health applications of Tinospora cordifolia (Guduchi): a miraculous herb countering various diseases/disorders and its immunomodulatory effects. Rec Patents Endocr Metab Immune Drug Discov 2016;10:96–111.
Pandey VK, Amin PJ, Shankar BS. G1-4A, a polysaccharide from Tinospora cordifolia induces peroxynitrite dependent killer dendritic cell (KDC) activity against tumor cells. Int Immunopharm 2014;23:480–488.
Bishayi B, Roychowdhury S, Ghosh S, Sengupta M. Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCl4 intoxicated mature albino rats. J Toxicolog Sci 2002;27:139–146.
Sharma B, Dabur R. Protective effects of Tinospora cordifolia on hepatic and gastrointestinal toxicity induced by chronic and moderate alcoholism. Alcohol Alcoholism 2016;51:1–10.
Sarala M, Velu V, Anandharamakrishnan C, Singh RP. Spray drying of Tinospora cordifolia leaf and stem extract and evaluation of antioxidant activity. J Food Sci Technol 2012;49:119–122.
Upadhyay N, Ganie SA, Agnihotri RK, Sharma R. Free radical scavenging activity of Tinospora cordifolia (Willd.) Miers. J Pharm Phytochem 2014;3:63–69.
Gupta R, Sharma V. Ameliorative effects of Tinospora cordifolia root extract on histopathological and biochemical changes induced by aflatoxin-B1 in mice kidney. Toxicol Int 2011;18:94.
Jain S, Sherlekar B, Barik R. Evaluation of antioxidant potential of Tinospora cordifolia and T. sinensis. Int J Pharm Sci Res 2010;1:122.
Paval J, Kaitheri SK, Govindan S, Mohammed CA, Kumar RS, Narayanan SN, et al. Anti-arthritic activity of the plant Tinospora cordifolia Willd. J Herb Med Toxicol 2011;5:11–16.
Bharathi C, Reddy AH, Nageswari G, Sri Laxmi B, Soumya M, Vanisri DS, et al. A review on medicinal properties of Tinospora cordifolia. Int J Sci Res Rev 2018;7:585–598.
Sannegowda KM, Venkatesha SH, Moudgil KD. Tinospora cordifolia inhibits autoimmune arthritis by regulating key immune mediators of inflammation and bone damage. Int J Immunopathol Pharmacol 2015;28:521–531.
Abiramasundari G, Sumalatha KR, Sreepriya M. Effects of Tinospora cordifolia (Menispermaceae) on the proliferation, osteogenic differentiation and mineralization of osteoblast model systems in vitro. J Ethnopharmacol 2012;141:474–480.
Rajalakshmi M, Eliza J, Priya CE, Nirmala A, Daisy P. Anti-diabetic properties of Tinospora cordifolia stem extracts on streptozotocin-induced diabetic rats. Afr J Pharm Pharmacol 2009;3:171–180.
Sangeetha MK, Priya CM, Vasanthi HR. Anti-diabetic property of Tinospora cordifolia and its active compound is mediated through the expression of Glut-4 in L6 myotubes. Phytomedicine 2013;20:246–248.
Nethravathi PC, Kumar MP, Suresh D, Lingaraju K, Rajanaika H, Nagabhushana H, et al. Tinospora cordifolia mediated facile green synthesis of cupric oxide nanoparticles and their photocatalytic, antioxidant and antibacterial properties. Mater Sci Semiconduct Proc 2015;33:81–88.
Mishra A, Kumar S, Pandey AK. Scientific validation of the medicinal efficacy of Tinospora cordifolia. Sci World J 2013;2013.
Agarwal S, Ramamurthy PH, Fernandes B, Rath A, Sidhu P. Assessment of antimicrobial activity of different concentrations of Tinospora cordifolia against Streptococcus mutans: an in vitro study. Dental Res J 2019;16:24.
Thakkar SS, Shelat F, Thakor P. Magical bullets from an indigenous Indian medicinal plant Tinospora cordifolia: an in-silico approach for the antidote of SARS-CoV-2. Egyp J Petroleum 2021;30:53–66.
Sapra L, Bhardwaj A, Azam Z, Madhry D, Verma B, Rathore S, Srivastava RK. Phytotherapy for treatment of cytokine storm in COVID-19. Frontiers Biosci 2021;26:51–75.
Shree P, Mishra P, Selvaraj C, Singh SK, Chaube R, Garg N, et al. Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants—Withania somnifera (Ashwagandha), Tinospora cordifolia (Giloy) and Ocimum sanctum (Tulsi)—a molecular docking study. J Biomolec Struct Dynamics 2020;40:1–14.
Chowdhury P. In silico investigation of phytoconstituents from Indian medicinal herb ‘Tinospora cordifolia (giloy)’ against SARS-CoV-2 (COVID-19) by molecular dynamics approach. J Biomol Struct Dynamics 2020;39:1–8.
Rao PR, Kumar VK, Viswanath RK, Subbaraju GV. Cardioprotective activity of alcoholic extract of Tinospora cordifolia in ischemia-reperfusion induced myocardial infarction in rats. Biol Pharm Bull 2005;28:2319–2322.
Salve BA, Tripathi RK, Petare AU, Raut AA, Rege NN. Effect of Tinospora cordifolia on physical and cardiovascular performance induced by physical stress in healthy human volunteers. Ayurveda 2015;36:265.
Spandana U, Ali SL, Nirmala T, Santhi M, Babu SS. A review on Tinospora cordifolia. Int J Curr Pharm Rev Res 2013;4:61–68.
Sharma AK, Kishore K, Sharma D, Srinivasan BP, Agarwal SS, Sharma A, et al. Cardioprotective activity of alcoholic extract of Tinospora cordifolia (Willd.) Miers in calcium chloride-induced cardiac arrhythmia in rats. J Biomed Res 2011;25:280–286.
Antul K, Amandeep P, Gurwinder S, Anuj C. Review on pharmacological profile of medicinal vine: Tinospora cordifolia. Curr J Appl Sci Technol 2019:1.
Kosaraju J, Chinni S, Roy PD, Kannan E, Antony AS, Kumar MS. Neuroprotective effect of Tinospora cordifolia ethanol extract on 6-hydroxydopamine induced Parkinsonism. Ind J Pharmacol 2014;46:176.
Jain VK, Shete A. Antipsychotic activity of aqueous ethanolic extract of Tinospora cordifolia in amphetamine challenged mice model. J Adv Pharm Technol Res 2010;1:30.
Mishra R, Manchanda S, Gupta M, Kaur T, Saini V, Sharma A, et al. Tinospora cordifolia ameliorates anxiety-like behavior and improves cognitive functions in acute sleep deprived rats. Sci Rep 2016;6:1–5.
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Author is thankful to Integral University Lucknow for providing manuscript number IU/R&D/2022-MCN0001444.
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Ahsan R and Mishra A conceived and Badar B modified this manuscript, Ahsan R, Owais M and Mishra V have collected the literature. Ahsan R wrote the manuscript. Reviewers helped to revise the manuscript. All authors read and approved the manuscript.
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The authors declare no potential conflicts of interest concerning the review, authorship, and/or publication of this article.
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Ahsan, R., Mishra, A., Badar, B. et al. Therapeutic Application, Phytoactives and Pharmacology of Tinospora cordifolia: An Evocative Review. Chin. J. Integr. Med. 29, 549–555 (2023). https://doi.org/10.1007/s11655-023-3733-2
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DOI: https://doi.org/10.1007/s11655-023-3733-2