Abstract
Magnetic fluorescent dual-drug nanocomposites (MFDDs) were developed with the aim of simultaneouly delivering two different anticancer drugs, kaempferol (KAE) and paclitaxel (PTX). Firstly, Fe3O4/ bovine serum albumin (Fe3O4/BSA) composite microspheres with physically entrapped KAE were prepared, then microspheres were modified with PTX/graphene quantum dots (PTX/GQDs) through chemically bonding, and the MFDDs were obtained. The properties of nancomposites were characterized by X-ray diffractometry, Fourier-transform infrared spectroscopy, transmission electron microscopy, vibrating sample magnetometry and X-ray fluorescence spectrometry. It was found that the superparamagnetic nanocomposites had ultrafine size (below 110 nm), high saturation magnetization of 24.36 emu/g, and significant fluorescence. Furthermore, the cumulative in vitro release of the MFDDs exhibited controlled drug release. Cell viability experiments confirmed that the co-administration of KAE with PTX had a superior cytotoxicity to the Hela cells compared with single drug-loaded forms. Therefore, dual anticancer drug-loaded MFDDs have the potential to be used for cancer combined chemotherapy.
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Funded by the Natural Science Fund of Jiangsu Overseas Research & Training Program for University Prominent Young & Middle-aged Teachers and Presidents, the Natural Science Fund of Jiangsu Province (No.BK20130094), the Enterpriseuniversities Cooperative Innovation Fund of Jiangsu Province (No. BY2014016) and the National Natural Science Foundation of China (No.51103066)
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Zhang, X., Pan, Q., Hao, L. et al. Preparation of magnetic fluorescent dual-drug nanocomposites for codelivery of kaempferol and paclitaxel. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 33, 256–262 (2018). https://doi.org/10.1007/s11595-018-1814-z
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DOI: https://doi.org/10.1007/s11595-018-1814-z