Abstract
The synthesis of amphiphilic aggregation-induced emission (AIE) dyes based organic nanoparticles has recently attracted increasing attention in the biomedical fields. These AIE dyes based nanoparticles could effectively overcome the aggregation caused quenching effect of conventional organic dyes, making them promising candidates for fabrication of ultrabright organic luminescent nanomaterials. In this work, AIE-active luminescent polymeric nanoparticles (4-NH2-PEG-TPE-E LPNs) were facilely fabricated through Michael addition reaction between tetraphenylethene acrylate (TPE-E) and 4-arm-poly(ethylene glycol)-amine (4-NH2-PEG) in rather mild ambient. The 4-NH2-PEG can not only endow these AIE-active LPNs good water dispersibility, but also provide functional groups for further conjugation reaction. The size, morphology and luminescent properties of 4-NH2-PEG-TPE-E LPNs were characterized by a series of techniques in detail. Results suggested that these AIE-active LPNs showed spherical morphology with diameter about 100–200 nm. The obtained 4-NH2-PEG-TPE-E LPNs display high water dispersibility and strong fluorescence intensity because of their self assembly and AIE properties of TPE-E. Biological evaluation results demonstrated that 4-NH2-PEG-TPE-E LPNs showed negative toxicity toward cancer cells and good fluorescent imaging performance. All of these features make 4-NH2-PEG-TPE-E LPNs promising candidates for biological imaging and therapeutic applications.
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References
Feng X, Liu L, Wang S, Zhu D. Chem Soc Rev, 2010, 39: 2411–2419
Hu R, Leung NL, Tang BZ. Chem Soc Rev, 2014, 43: 4494–4562
Wu W, Tang R, Li Q, Li Z. Chem Soc Rev, 2015, 12: 3997–4022
Breul AM, Hager MD, Schubert US. Chem Soc Rev, 2013, 42: 5366–5407
Zhang X, Wang S, Xu L, Ji Y, Feng L, Tao L, Li S, Wei Y. Nanoscale, 2012, 4: 5581–5584
Qin A, Lam JW, Tang BZ. Prog Polym Sci, 2012, 37: 182–209
Wang K, Zhang X, Zhang X, Fan X, Huang Z, Chen Y, Wei Y. Polym Chem, 2015, 6: 5891–5898
Chandra S, Pathan SH, Mitra S, Modha BH, Goswami A, Pramanik P. RSC Adv, 2012, 2: 3602–3606
De B, Karak N. RSC Adv, 2013, 3: 8286–8290
Liu S, Zhang H, Qiao Y, Su X. RSC Adv, 2012, 2: 819–825
Luo PG, Yang F, Yang ST, Sonkar SK, Yang L, Broglie JJ, Liu Y, Sun YP. RSC Adv, 2014, 4: 10791–10807
Hui J, Zhang X, Zhang Z, Wang S, Tao L, Wei Y, Wang X. Nanoscale, 2012, 4: 6967–6970
Zhang X, Wang S, Liu M, Yang B, Feng L, Ji Y, Tao L, Wei Y. Phys Chem Chem Phys, 2013, 15: 19013–19018
Zheng X, Liu M, Hui J, Fan D, Ma H, Zhang X, Wang Y, Wei Y. Phys Chem Chem Phys, 2015, 17: 20301–20307
Zhang X, Hui J, Yang B, Yang Y, Fan D, Liu M, Tao L, Wei Y. Polym Chem, 2013, 4: 4120–4125
Zhang X, Wang S, Zhu C, Liu M, Ji Y, Feng L, Tao L, Wei Y. J Colloid Interf Sci, 2013, 397: 39–44
Díez I, Ras RHA. Nanoscale, 2011, 3: 1963–1970
Liu M, Zhang X, Yang B, Deng F, Ji J, Yang Y, Huang Z, Zhang X, Wei Y. RSC Adv, 2014, 4: 22294–22298
Tang L, Jin J, Zhang S, Mao Y, Sun J, Yuan W, Zhao H, Xu H, Qin A, Tang BZ. Sci China Chem, 2009, 52: 755–759
Gao Y, Zhang H, Jiang T, Yang J, Li B, Li Z, Hua J. Sci China Chem, 2013, 56: 1204–1212
Li Q, Li Z. Sci China Chem, 2015, 58: 1800–1809
Liang J, Feng G, Kwok RTK, Ding D, Tang B, Liu B. Sci China Chem, 2016, 59: 53–61
Qin A, Zhang Y, Han N, Mei J, Sun J, Fan W, Tang BZ. Sci China Chem, 2012, 55: 772–778
Hu X, Li Y, Liu T, Zhang G, Liu S. Sci China Chem, 2014, 57: 615–623
Wang D, Cao W, Fan J. Sci China Chem, 2014, 57: 791–796
Huang Z, Zhang X, Zhang X, Wang S, Yang B, Wang K, Yuan J, Tao L, Wei Y. RSC Adv, 2015, 5: 65884–65889
Li K, Qin W, Ding D, Tomczak N, Geng J, Liu R, Liu J, Zhang X, Liu H, Liu B. Sci Rep, 2013, 3: 1150
Hong Y, Lam JWY, Tang BZ. Chem Soc Rev, 2011, 40: 5361–5388
Luo J, Xie Z, Lam JWY, Cheng L, Chen H, Qiu C, Kwok HS, Zhan X, Liu Y, Zhu D, Tang BZ. Chem Commun, 2001, 37: 1740–1741
Zhang X, Zhang X, Wang S, Liu M, Tao L, Wei Y. Nanoscale, 2013, 5: 147–150
Zhang X, Wang K, Liu M, Zhang X, Tao L, Chen Y, Wei Y. Nanoscale, 2015, 7: 11486–11508
Zhang X, Zhang X, Yang B, Liu L, Hui J, Liu M, Chen Y, Wei Y. RSC Adv, 2014, 4: 10060–10066
Zhang X, Zhang X, Wang S, Liu M, Zhang Y, Tao L, Wei Y. ACS Appl Mater Interf, 2013, 5: 1943–1947
Wang K, Zhang X, Zhang X, Yang B, Li Z, Zhang Q, Huang Z, Wei. Polym Chem, 2015, 6: 1360–1366
Mei J, Leung NL, Kwok RT, Lam JW, Tang BZ. Chem Rev, 2015, 115: 11718–11940
Yang J, Huang J, Li Q, Li Z. J Mater Chem C, 2016, DOI: 10.1039/C1035TC03262H
Zhang X, Zhang X, Yang B, Liu M, Liu W, Chen Y, Wei Y. Poly Chem, 2014, 5: 399–404
Feng G, Tay CY, Chui QX, Liu R, Tomczak N, Liu J, Tang BZ, Leong DT, Liu B. Biomaterials, 2014, 35: 8669–8677
Yuan Y, Kwok RT, Zhang R, Tang BZ, Liu B. Chem Commun, 2014, 50: 11465–11468
Yuan WZ, Mahtab F, Gong Y, Yu ZQ, Lu P, Tang Y, Lam JW, Zhu C, Tang BZ. J Mater Chem, 2012, 22: 10472–10479
Li K, Liu B. Chem Soc Rev, 2014, 43: 6570–6597
Geng J, Li K, Ding D, Zhang X, Qin W, Liu J, Tang BZ, Liu B. Small, 2012, 8: 3655–3663
Yuan Y, Chen Y, Tang BZ, Liu B. Chem Commun, 2014, 50: 3868–3870
Liu M, Ji J, Zhang X, Zhang X, Yang B, Deng F, Li Z, Wang K, Yang Y, Wei Y. J Mater Chem B, 2015, 3: 3476–3482
Wan Q, Wang K, Du H, Huang H, Liu M, Deng F, Dai Y, Zhang X, Wei Y. Polym Chem, 2015, 6: 5288–5294
Liu Z, Davis C, Cai W, He L, Chen X, Dai H. Proc Natl Acad Sci USA, 2008, 105: 1410–1415
Greenwald R. J Control Release, 2001, 74: 159–171
Otsuka H, Nagasaki Y, Kataoka K. Adv Drug Deliver Rev, 2012, 64: 246–255
Zhang X, Wang S, Fu C, Feng L, Ji Y, Tao L, Li S, Wei Y. Polym Chem, 2012, 3: 2716–2719
Zhang X, Fu C, Feng L, Ji Y, Tao L, Huang Q, Li S, Wei Y. Polymer, 2012, 53: 3178–3184
Zhang X, Zeng G, Tian J, Wan Q, Huang Q, Wang K, Zhang Q, Liu M, Deng F, Wei Y. Appl Surf Sci, 2015, 351: 425–432
Wan Q, Liu M, Tian J, Deng F, Zeng G, Li Z, Wang K, Zhang Q, Zhang X, Wei Y. Polym Chem, 2015, 6: 1786–1792
Wan Q, Mao L, Liu M, Wang K, Zeng G, Xu D, Huang H, Zhang X, Wei Y. Polym Chem, 2015, 6: 7211–7218
Qin W, Ding D, Liu J, Yuan WZ, Hu Y, Liu B, Tang BZ. Adv Funct Mater, 2012, 22: 771–779
Qin W, Li K, Feng G, Li M, Yang Z, Liu B, Tang BZ. Adv Funct Mater, 2014, 24: 635–643
Zhang X, Zhang X, Yang B, Liu M, Liu W, Chen Y, Wei Y. Polym Chem, 2013, 4: 4317–4321
Zhang X, Zhang X, Yang B, Liu M, Liu W, Chen Y, Wei Y. Polym Chem, 2014, 5: 356–360
Zhang X, Qi H, Wang S, Feng L, Ji Y, Tao L, Li S, Wei Y. Toxicol Res, 2012, 1: 201–205
Zhang X, Wang S, Liu M, Hui J, Yang B, Tao L, Wei Y. Toxicol Res, 2013, 2: 335–346
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Chu, J., Lv, Q., Guo, C. et al. One-step preparation of branched PEG functionalized AIE-active luminescent polymeric nanoprobes. Sci. China Chem. 59, 1003–1009 (2016). https://doi.org/10.1007/s11426-016-5578-z
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DOI: https://doi.org/10.1007/s11426-016-5578-z