Abstract
Autophagy is a basic cellular process that decomposes damaged organelles and aberrant proteins. Dysregulation of autophagy is implicated in pathogenesis of neurodegenerative disorders, including Parkinson’s disease (PD). Pharmacological compounds that stimulate autophagy can provide neuroprotection in models of PD. Nanoparticles have emerged as regulators of autophagy and have been tested in adjuvant therapy for diseases. In this present study, we explore the effects of quantum dots (QDs) that can induce autophagy in a cellular model of Parkinson’s disease. CdTe/CdS/ZnS QDs protect differentiated rat pheochromocytoma PC12 cells from MPP+-induced cell damage, including reduced viability, apoptosis and accumulation of α-Synuclein, a characteristic protein of PD. The protective function of QDs is autophagy-dependent. In addition, we investigate the interaction between quantum dots and autophagic pathways and identify beclin1 as an essential factor for QDs-induced autophagy. Our results reveal new promise of QDs in the theranostic of neurodegenerative diseases.
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Wu C, Shi L, Wu C, Guo D, Selke M, Wang X. Sci China Chem, 2014, 57: 1579–1588
Hou S, Liang L, Deng S, Chen J, Huang Q, Cheng Y, Fan C. Sci China Chem, 2014, 57: 100–106
Markovic ZM, Ristic BZ, Arsikin KM, Klisic DG, Harhaji-Trajkovic LM, Todorovic-Markovic BM, Kepic DP, Kravic-Stevovic TK, Jovanovic SP, Milenkovic MM, Milivojevic DD, Bumbasirevic VZ, Dramicanin MD, Trajkovic VS. Biomaterials, 2012, 33: 7084–7092
Winnik FM, Maysinger D. Accounts Chem Res, 2013, 46: 672–680
Wu T, Zhang T, Chen Y, Tang M. J Appl Toxicol, 2016, 36: 345–351
Chen N, He Y, Su YY, Li XM, Huang Q, Wang HF, Zhang XZ, Tai RZ, Fan CH. Biomaterials, 2012, 33: 1238–1244
Li XM, Chen N, Su YY, He Y, Yin M, Wei M, Wang LH, Huang W, Fan CH, Huang Q. Adv Healthc Mater, 2014, 3: 354–359
Zhou Y, Wang Q, Song B, Wu S, Su Y, Zhang H, He Y. Biomaterials, 2015, 72: 38–48
Tsoi KM, Dai Q, Alman BA, Chan WC. Accounts Chem Res, 2013, 46: 662–671
Yong KT, Law WC, Hu R, Ye L, Liu L, Swihart MT, Prasad PN. Chem Soc Rev, 2013, 42: 1236–1250
Bove J, Martinez-Vicente M, Vila M. Nat Rev Neurosci, 2011, 12: 437–452
Tian T, Zhang JC, Lei HZ, Ying Z, Shi JY, Hu J, Huang Q, Fan CH, Sun YH. Nucl Sci Technol, 2015, 26: 100–105
Winslow AR, Chen CW, Corrochano S, Acevedo-Arozena A, Gordon DE, Peden AA, Lichtenberg M, Menzies FM, Ravikumar B, Imarisio S, Brown S, O’Kane CJ, Rubinsztein DC. J Cell Biol, 2010, 190: 1023–1037
Xilouri M, Vogiatzi T, Vekrellis K, Stefanis L. Autophagy, 2008, 4: 917–919
Liu K, Huang J, Chen R, Zhang T, Shen L, Yang J, Sun X. Braz J med Biol Res, 2012, 45: 401–407
Lipinski MM, Zheng B, Lu T, Yan ZY, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR, Yuan JY. Proc Natl Acad Sci USA, 2010, 107: 14164–14169
Renna M, Jimenez-Sanchez M, Sarkar S, Rubinsztein DC. J Biol Chem, 2010, 285: 11061–11067
Zabirnyk O, Yezhelyev M, Seleverstov O. Autophagy, 2007, 3: 278–281
Yu L, Lu Y, Man N, Yu SH, Wen LP. Small, 2009, 5: 2784–2787
Khan MI, Mohammad A, Patil G, Naqvi SAH, Chauhan LKS, Ahmad I. Biomaterials, 2012, 33: 1477–1488
Zhang YJ, Zheng F, Yang TL, Zhou W, Liu Y, Man N, Zhang L, Jin N, Dou QQ, Zhang Y, Li ZQ, Wen LP. Nat Mater, 2012, 11: 817–826
Wei PF, Zhang L, Nethi SK, Barui AK, Lin J, Zhou W, Shen Y, Man N, Zhang YJ, Xu J, Patra CR, Wen LP. Biomaterials, 2014, 35: 899–907
Wei PF, Jin PP, Barui AK, Hu Y, Zhang L, Zhang JQ, Shi SS, Zhang HR, Lin J, Zhou W, Zhang YJ, Ruan RQ, Patra CR, Wen LP. Biomaterials, 2015, 73: 160–174
Wei PF, Zhang L, Lu Y, Man N, Wen LP. Nanotechnology, 2010, 21: 1–11
Hung KC, Huang HJ, Lin MW, Lei YP, Lin AM. PLoS One, 2014, 9: e91074
He C, Klionsky DJ. Annu Rev Genet, 2009, 43: 67–93
Zhong WY, Min L, Liu LY, Sun JL, Zhong ZT, Zhao Y, Song HY. Chin Sci Bull, 2013, 58: 4031–4038
Klionsky DJ, Abeliovich H, Agostinis P, et al. Autophagy, 2008, 4: 151–175
Dadakhujaev S, Noh HS, Jung EJ, Cha JY, Baek SM, Ha JH, Kim DR. Neurosci Lett, 2010, 472: 47–52
Ronan B, Flamand O, Vescovi L, Dureuil C, Durand L, Fassy F, Bachelot MF, Lamberton A, Mathieu M, Bertrand T, Marquette JP, El-Ahmad Y, Filoche-Romme B, Schio L, Garcia-Echeverria C, Goulaouic H, Pasquier B. Nat Chem Biol, 2014, 10: 1013–1019
Luo YH, Wu SB, Wei YH, Chen YC, Tsai MH, Ho CC, Lin SY, Yang CS, Lin P. Chem Res Toxicol, 2013, 26: 662–673
Zhang Y, Wang Z, Li X, Wang L, Yin M, Wang L, Chen N, Fan C, Song H. Adv Mater, 2015, 28: 1387–1393
Spencer B, Potkar R, Trejo M, Rockenstein E, Patrick C, Gindi R, Adame A, Wyss-Coray T, Masliah E. J Neurosci, 2009, 29: 13578–13588
Wang RC, Wei Y, An Z, Zou Z, Xiao G, Bhagat G, White M, Reichelt J, Levine B. Science, 2012, 338: 956–959
Wong E, Cuervo AM. Nat Neurosci, 2010, 13: 805–811
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Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson’s disease through autophagy induction
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Wang, L., Li, X., Han, Y. et al. Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson’s disease through autophagy induction. Sci. China Chem. 59, 1486–1491 (2016). https://doi.org/10.1007/s11426-016-0103-7
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DOI: https://doi.org/10.1007/s11426-016-0103-7