Abstract
An approach for the preparation of a polymer delivery system consisting of sodium alginate (SA) and carbopol was developed. The efficiency of the inclusion of medicinal compounds in these systems was investigated using the polyphenols curcumin and resveratrol as examples. Curcumin and resveratrol possess anti-inflammatory, antitumor, and antibacterial effects, which makes them promising compounds for use in clinical practice. The main disadvantage of these polyphenols is their low bioavailability. The formation of microcapsules occurs due to the precipitation of a mixture of SA and carbopol (carbopol 940 or ETD 2020), containing a model object, in a calcium chloride solution. The dependence of the inclusion of drugs in microcapsules and their release into gastrointestinal environment imitators on the viscosity characteristics of carbopol, which is part of the microcapsule shell, was investigated.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
J. Li, D. J. Mooney, Nat. Rev. Mater., 2016, 1, 16071; DOI: https://doi.org/10.1038/natrevmats.2016.71.
M. Ebara, Y. Kotsuchibashi, R. Narain, N. Idota, Y.-J. Kim, J. M. Hoffman, K. Uto, T. Aoyagi, in Smart Biomaterials, Springer, Tokyo, 2014, 380 pp.
A. K. Bajpai, J. Bajpai, R. K. Saini, P. Agrawal, A. Tiwary, in Smart Biomaterial Devices, Taylor and Francis Group, Boca Raton, 2017, 242 pp.
S. Swain, A. Behera, S. Beg, Recent Pat. Drug Del. Form., 2012, 6, 259.
R. V. Ulijn, N. Bibi, V. Jayawarna, P. D. Thornton, S. J. Todd, R. J. Mart, A. M. Smith, J. E. Gough, Mater. Today, 2007, 10, No. 4, 40.
A. Alekseev, S. A. Kedik, Farmatsevticheskaya tekhnologiya [Pharmaceutical Technology], AO IFT, Moscow, 2019, 570 pp. (in Russian).
N. B. Demina, E. O. Bakhrushina, A. I. Bardakov, I. I. Krasnyuk, Farmatsiya [Pharmacy], 2019, 68, 12 (in Russian).
W. R. Gombotz, S. F. Wee, Adv. Drug. Del. Rev., 1998, 31, 267.
W. Hu, L. Huang, W. Jin, P. Ge, B. R. Shah, D. Zhu, J. Jing, Int. J. Biol. Macromol., 2019, 134, 210.
E. V. Popova, Ph. D. Thesis (Chem.) Univ. of Information Technologies, Mechanics and Optics, Research Inst. of Hygiene, Occupational Pathology, and Human Ecology of FMBA of Russia, Saint Petersburg, 2017, 120 pp. (in Russian).
R. Sun, Q. Xia, Coll. Surf. A: Physicochem. Eng. Asp., 2019, 574, 197.
A. Badwan, A. Abumalooh, E. Sallam, A. Abukalaf, O. Jawan, Drug. Develop. Ind. Pharm., 1985, 11, 239.
S. Y. Lin, J. W. Ayres, Pharm. Res., 1992, 9, 1128.
L. Lin-Shu, L. Shu-Qin, Y. Ng Steven, M. Froix, T. Ohno, Control. Release J., 2000, 43, 65.
C. A. Garcia-Gonsalez, M. Alnaief, I. Smirnova, Carbohydr. Polym., 2011, 86, 1425.
K. Moebus, J. Siepmann, R. Bodmeier, Eur. J. Pharm. Sci., 2012, 45, 358.
T. Hu, Q. Liu, T. Gao, K. Dong, G. Wei, J. Yao, ACS Omega, 2018, 3, 7523.
C. Bertagnolli, A. Grishin, T. Vincent, E. Guibal, J. Environ. Sci. Health, Part. A, 2017, 52, 359.
T. Wu, S. Yu, D. Lin, Z. Wu, ACS Appl. Bio Mater., 2020, 3, 3057.
A. I. Tentsova, M. T. Alyushina, Polimery v farmatsii [Polymers in Pharmacy], Meditsina, Moscow, 1985, 256 pp. (in Russian).
A. M. Lopez-Cacho, R. Alvares, J. M. Gonsales Rodriguez, B. Talero, B. Gonsales Rodriguez, Sci. World J., 2012, 1.
S. H. Neau, M. Y. Chow, M. J. Durrani, Int. J. Pharm., 1996, 131, 47.
N. Desai, S. P. Jain, Res. Rev.: J. Pharm. Sci., 2011, 2, 2.
S. Parker-Leggs, S. H. Neau, Int. J. Pharm., 2008, 361, 169.
P. Anand, A. B. Kunnumakkara, R. A. Newman, B. B. Aggarwal, Mol. Pharm., 2007, 4, 807.
N. Rabiee, S. Deljoo, M. Rabiee, Asian J. Nanosci. Mater., 2018, 2, 66.
V. P. Menon, A. R. Sudheer, The Molecular Targets and Therapeutic Uses of Curcumine in Health and Disease, Vol. 595, Springer, Boston, 2007, p. 105.
S. S. Bansal, M. Goel, F. Aqil, M. V. Vadhanam, R. C. Gupta, Cancer. Prev. Res., 2011, 4, 1158.
M. Saheb, N. Fereydouni, S. Nemati, G. Barreto, T. Johnstone, A. Sahebkar, J. Cell. Physiol., 2019, 234, 12325.
L. Dai, H. Zhou, Y. Wei, Y. Gao, D. J. McClements, Food Hydrocoll., 2019, 93, 342.
A. Rajput, A. Bariya, A. Allam, S. Othman, S. B. Butani, Drug. Del. Transl. Res., 2018, 8, 1460.
J. Li, G. H. Shin, X. Chen, J. H. Park, Food Res. Int., 2015, 69, 202.
F. Bai, Y. Wang, Q. Han, M. Wu, Q. Luo, H. Zhang, Y. Wang, J. Mol. Liq., 2019, 288, 111079.
S. Karthikeyan, N. Rajendra Prasad, A. Ganamani, E. Balamurugan, Biomed. Prev. Nutr., 2013, 3, 64.
A. Amri, J. C. Chaumeil, S. Sfar, C. Charrueau, J. Control. Release, 2012, 185, 182.
Author information
Authors and Affiliations
Corresponding author
Additional information
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1335–1340, July, 2021.
This paper does not contain descriptions of studies on animals or humans.
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Popova, E.V., Morozova, P.V., Uspenskaya, M.V. et al. Sodium alginate and carbopol microcapsules: preparation, polyphenol encapsulation and release efficiency. Russ Chem Bull 70, 1335–1340 (2021). https://doi.org/10.1007/s11172-021-3220-5
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11172-021-3220-5