Abstract
The influence of exogenous factors on the selectivity of biotransformation of cholesterol 3β-methyl ether by Mycobacterium sp. was studied. The main product of the microbiological transformation was Δ5-dehydroepiandrosterone 3β-methyl ether. The presence of methyl-β-cyclodextrin in the bacterial growth medium led to a change in the ratio of the reaction products and an increase in the yield of Δ4-androstene-3,17-dione. Aliphatic saturated and unsaturated carboxylic acids were also formed in the course of biotransformation.
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The present publication does not contain a description of the research performed by the authors involving humans or animals as objects.
The authors declare that they have no conflicts of interest in financial or any other area.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 533–538, March, 2021.
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Yaderets, V.V., Karpova, N.V., Stytsenko, T.S. et al. Study of biotransformation of cholesterol 3β-methyl ether by mycobacteria Mycobacterium sp.. Russ Chem Bull 70, 533–538 (2021). https://doi.org/10.1007/s11172-021-3120-8
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DOI: https://doi.org/10.1007/s11172-021-3120-8