Abstract
Chiral phenyl substituted bis(oxazoline) (PhBox) was covalently immobilized through carbamate linkers onto mesoporous silica materials. These supports were previously prepared by the sol–gel method and they exhibit different textural properties. The presence and the integrity of the bis(oxazoline) ligand was checked by 13C-CP-MAS-NMR. These chiral mesoporous materials were complexed with copper(II) triflate. In spite of the different textural properties of these supports, the copper loading, determined by ICP-AES, was nearly the same (0.041–0.044 mmol Cu/g of solid). The supported Cu(II) complexes were tested as catalysts in the enantioselective cyclopropanation of styrene with ethyl diazoacetate. Enantioselectivities are consistently lower than those obtained in homogeneous phase. Different analyses point to a difficulty in the formation of the expected chelate, due to the presence of a coordinating functional group in the linker, as responsible for the loss in enantioselectivity. The textural properties of the materials do significantly affect the behavior upon recovery.
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Introduction
The development of new heterogeneous catalysts able to promote enantioselective organic reactions is a field of growing interest because of the important advantages of heterogeneous to homogenous catalysts, the main one being that the supported catalyst can be easily recovered and then reused [1, 2]. The immobilization of chiral homogeneous catalysts on solid insoluble supports is the most common method to prepare chiral heterogeneous catalysts, and two general approaches can be used for this immobilization: the first one consists of covalently fixing the chiral ligand to the support [3, 4], whereas the second one uses some non-covalent interaction between the complex and the solid support [5]. The main advantage of the covalent immobilization is to avoid the leaching of the valuable chiral ligand. As solid support, organic polymers and different kinds of silica are commonly used for the covalent attachment. Silica supported catalysts show in principle stronger mechanical resistance and a structure which is independent from the solvent used. Moreover, the restriction in the attack trajectories to the chiral complex in mesoporous solids has been the origin of interesting confinement effects on selectivity [6, 7].
As chiral ligands, bis(oxazolines) are among the most versatile ones, since they form complexes with different cations and can promote a large variety of enantioselective organic reactions [8]. Their metal complexes have been immobilized on mesoporous materials through non-covalent interactions, such as hydrogen-bonding [9] and electrostatic interactions [10–12]. The covalent immobilization of bis(oxazoline) ligands on silica support could be achieved in situ by sol–gel method or by grafting on a pre-formed support. The synthesis by the sol–gel process [13] presents the problem that the bis(oxazoline) ligands are sensitive to hydrolysis in aqueous acidic media, together with the possible occlusion of the ligand in non-accessible parts of the hybrid material. Regarding grafting on different silica supports, one key point is the choice of the spacer linking the bis(oxazoline) ligand and the support. A simple alkyl chain has been used, either anchoring an alkyl halide on the silica support and making it to react with a methylene bis(oxazoline) [14–18] or alkylating first the ligand and then grafting the modified bis(oxazoline) [19–21]. In other cases, the spacer has functional groups, such as thioether [22, 23], ether [24, 25], carbamate [26–28] or even polyfunctional spacers prepared by click chemistry [29]. Some of those works deal with the covalent immobilization on amorphous silicas and in other examples ordered mesoporous materials are used as supports, namely MCM41 and MCM48 [14, 23], SBA15 and HMS [17, 18, 25], mesocellular foam silicas [19–21, 24], and hierarchically-ordered mesocellular mesoporous silica [29].
In this work, the anchoring of phenyl substituted bis(oxazoline) ligand to mesoporous silica through a carbamate linker CH2–O–CONH–(CH2)3 is reported, used until now only to immobilize the indane [26, 27] and the tert-butyl [28] bis(oxazolines). The catalytic performance in the cyclopropanation between styrene and ethyl diazoacetate is compared with the analogous indane derivative [30].
Experimental
Synthesis of mesoporous supports
To a solution of tetraethoxysilane (TEOS, 9.1 mL, 40 mmol) in propanol (20 mL) at the required temperature was added either acetic or propionic acid (4 mmol) and then water (4.2 mL). The final molar composition of the mixture was TEOS:propanol:H2O:acid = 1:6.5:6:0.1. The resulting solution was stirred at the same temperature until gelification, and then for an additional period of 24 h. The resulting product was transferred into a Teflon-lined autoclave to be aged at 120 °C for 24 h, and finally it was dried at 120 °C for 24 h in an oven.
Synthesis of the chiral ligand
2,2′-Methylenebis[(4S)-4-phenyl-2-oxazoline] (PhBox) was synthesized by reacting (S)-2-phenylglycinol (10 mmol, 1.37 g) with diethyl malonimidate dihydrochloride (5 mmol, 1.15 g) in dichloromethane (100 mL). After 15 h of stirring at room temperature the resulting mixture was extracted three times with 100 mL of H2O. The organic fraction was dried with MgSO4 and the solvent was removed under reduced pressure to obtain a yellow liquid [31].
1H NMR (300 MHz, CDCl3, δ/ppm): 7.26–7.20 (m, 10H), 5.22 (m, 2H), 4.67 (t, 2H), 4.11 (t, 2H), 3.51 (s, 2H); 13C NMR (75 MHz, CDCl3, δ/ppm): 162.0, 141.6, 128.6, 127.5, 126.6, 75.2, 69.7, 28.3.
After that, the ligand was functionalized in the methylene bridge by hydroxymethylation. PhBox (1 mmol, 0.308 g) was added to a solution of paraformaldehyde (2.5 mmol, 78 mg) in CH2Cl2 (4 mL). After that dioxane (1 mL) and water (0.2 mL) were added. Finally, a solution of triethylamine (2.96 mmol, 0.4 mL) in tetrahydrofuran (3 mL) was added dropwise in 3 h and the mixture was kept under stirring at room temperature. After 3 days, the solvent was evaporated under reduced pressure, CH2Cl2 (20 mL) was added and the solution was washed with water (3 × 20 mL). The organic phase was dried with MgSO4 and the solvent was removed under reduced pressure.
1H NMR (300 MHz, CDCl3, δ/ppm): 7.32–7.24 (m, 10H), 5.21 (m, 2H), 4.68 (t, 2H), 4.12 (t, 2H), 3.74 (m, 4H), 3.70 (s, 2H); 13C NMR (75 MHz, CDCl3, δ/ppm): 161.9, 141.6, 128.8, 127.8, 126.5, 75.0, 69.0, 67.0, 64.5.
The hydroxymethylated ligand was made react with 3-isocyanatopropyltriethoxysilane [26, 27]. The hydroxymethylated ligand (1 mmol, 0.364 g) was added to a solution of dry triethylamine (3.3 mmol, 0.5 mL) in dry toluene (5 mL) under inert atmosphere. The 3-isocyanatopropyltriethoxysilane (2.2 mmol, 0.55 mL) was added dropwise for 20 min. The mixture was kept under stirring at room temperature for 48 h. The solvent was evaporated under reduced pressure and the crude reaction was used for grafting without further purification.
1H NMR (300 MHz, CDCl3, δ/ppm): 7.98 (s, 2H), 7.32–7.24 (m, 10H), 5.23 (m, 2H), 5.01 (t, 4H), 4.68 (t, 2H), 4.12 (t, 2H), 3.78 (m, 12H); 3.13 (m,4H), 1.56 (m, 4H), 1.19 (m, 18H), 0.60 (m, 4H). 13C NMR (75 MHz, CDCl3, δ/ppm): 162.2, 158.3, 142.0, 128.5, 127.4, 126.4, 75.2, 70.1, 58.1, 42.6, 36.2, 31.1, 23.4, 18.0, 7.3.
Immobilization of the ligand onto the supports
The corresponding dried silica support (500 mg) was added to a solution of functionalized PhBox (150 mg, 0.17 mmol) in anhydrous toluene (5 mL) and the resulting suspension was heated under reflux for 48 h under inert atmosphere. The solid was filtered, thoroughly washed with toluene and dichloromethane, and dried under vacuum. The copper complexes were prepared by the addition of Cu(OTf)2 (35 mg, 0.098 mmol) to a suspension of the bis(oxazoline)-containing material (570 mg) in anhydrous methanol (2 mL). After 15 h stirring, the solid was filtered, washed with methanol and dried under vacuum.
Characterization
Nitrogen physisorption experiments were performed at 77 K on an ASAP 2000 apparatus. The surface area was calculated using the BET method [32]. The pore size distribution was obtained from the desorption branch of isotherms using the BJH method [33]. 13C-CP-MAS-NMR spectra were recorded at 100.62 MHz on a Bruker Avance SB 400 MHz spectrometer at room temperature and magic angle spinning at 4000 Hz, with 5.2 µs excitation pulse and 5 s recycle time. Copper analysis was carried out on a Perkin-Elmer Plasma Emission spectrometer.
Cyclopropanation reaction
The solid catalyst (160 mg) was added to a solution of styrene (156 mg, 1.5 mmol) and n-decane (50 mg, internal standard) in anhydrous dichloromethane (2 mL). A solution of ethyl diazoacetate (171 mg, 1.5 mmol) in anhydrous dichloromethane (0.7 mL) was slowly added (2 h) with a syringe pump. The reaction was monitored by GC [34]. After the total conversion of diazoacetate, the catalyst was filtered off and washed with dichloromethane (5 mL), dried under vacuum and reused under the same conditions. The enantioselectivities were determined by gas chromatography with a Cyclodex-β column. The oven temperature program is an isotherm at 125 °C. The retention times for the different cyclopropanes are 28.9 min for (1S, 2R)-cyclopropane, 29.8 min for (1R, 2S)-cyclopropane, 34.3 min for (1R, 2R)-cyclopropane and 34.9 min for (1S, 2R)-cyclopropane.
Results and discussion
Synthesis and characterization of the chiral catalysts
Mesoporous silica materials were prepared by sol–gel method in propanol with a small amount of a carboxylic acid as catalyst without using any template [35]. The textural properties were determined from the N2 adsorption–desorption isotherms, which are given in Fig. 1 together with the pore size distribution. The results are gathered in Table 1.
Silica materials prepared by sol–gel show type IV N2 isotherms with different hysteresis loop shape, indicating the formation of mesoporous materials with different pore shape. Besides, these silica materials do not present any microporosity (Table 1). When the synthesis is carried out in propanol at 35 °C with acetic acid as catalyst (material S-1), a surface area of 876 m2/g and a main pore diameter of 35 Å were obtained. An increase in the synthesis temperature to 60 °C (material S-2) produces an increase in the void volume of the solid, which favors the formation of larger pores (mean pore diameter 120 Å) and larger total pore volume (1.12 cm3/g). When acetic acid is substituted by propionic acid (material S-3), the resulting solid exhibits large surface area (479 m2/g) and the highest total pore volume (1.76 cm3/g), with a very large mean pore diameter.
PhBox was functionalized with triethoxysilane groups through carbamate linkers (Scheme 1). The hydroxymethylation with paraformaldehyde was the first step followed by the reaction with 3-isocyanatopropyltriethoxysilane according to a method described in the literature [26, 27]. The resulting functionalized ligand was anchored onto the different silica supports (S-1, S-2 and S-3) in toluene under reflux to obtain the materials S-1-PhBox, S-2-PhBox and S-3-PhBox. These functionalized solids were characterized by 13C-CP-MAS-NMR, in order to check the presence and the integrity of the chiral ligand.
The 13C-CP-MAS-NMR spectra of the chiral materials S-1-PhBox, S-2-PhBox and S-3-PhBox are shown in Fig. 2. All the spectra are similar, revealing the presence of the most important signals of the bis(oxazoline) ligand and the carbamate linker. All the signals were assigned to the corresponding carbons as seen in Fig. 2. The presence of residual ethoxy groups indicates the incomplete condensation of the ethoxysilane with the surface silanols.
Finally, the materials containing the chiral ligand were complexed with Cu(OTf)2 in methanol (Scheme 1). These catalytic materials are labeled S-1-PhBox-Cu, S-2-PhBox-Cu and S-3-PhBox-Cu. The copper loading and the textural properties of the final catalysts were determined and they are gathered in Table 2. As can be seen, the immobilization of the chiral PhBox ligand and the subsequent copper complexation produces a drop in the surface area and total pore volume of the mesoporous materials S-1 to S-3, but with only a slight effect on the mean pore diameter. The copper loading in all the mesoporous chiral materials is very similar, from 0.041 to 0.044 mmol/g, in spite of the very different surface areas of the three supports. Thus the highest copper surface density, 0.13 µmol/m2, corresponds to the support with largest pores, probably due to an improved accessibility to the whole surface of the solid.
The ligand functionalization of the solid and the degree of ligand complexation with copper can be estimated from the elemental analysis. The results are collected in Table 3, together with those obtained in the grafting of the indane derived bis(oxazoline) on the same supports [30]. First of all, the C/N molar ratios, in the range of 7.5–7.8, are in good agreement with the theoretical value (7.25), also considering the presence of residual ethoxy groups, as shown in the NMR spectra (Fig. 2). It is also worth noting that the amount of PhBox grafted ligand, around 0.25 mmol/g, is significantly higher than in the case of indBox (around 0.18 mmol/g). This can be due to the higher flexibility of PhBox, in comparison with the polycyclic indBox, allowing an easier diffusion through the mesopores of the supports. On the contrary, the degree of complexation is rather low. The N/Cu molar ratio is around 23 in all the three solids, whereas the theoretical ratio for a total complexation is 4. This result is also very different from those obtained with the indBox ligand. In that case, the ligand complexation is not complete, either, but the N/Cu molar ratio is always lower, in the range of 8.6–13.3. It can be speculated that the easiness for diffusion of the more flexible PhBox ligand allows the grafting on sites that are later on inaccessible for Cu(OTf)2.
Results in the cyclopropanation reaction
The immobilized copper(II) complexes were tested as catalysts in the benchmark cyclopropanation reaction between styrene and ethyl diazoacetate represented in Scheme 2. The catalytic results are gathered in Table 4, together with those obtained with the analogous indane derived bis(oxazoline) ligand (indBox) grafted on the same silica supports [30].
The homogeneous PhBox(Me2)-Cu complex leads to moderate enantioselectivities for both cis (51 % e.e.) and trans (60 % e.e.) isomers, as well as moderate yield (due to the competitive side dimerization of the diazocompound) and the typical trans/cis selectivity, close to 70/30 [36]. In the case of the immobilized catalysts, the enantioselectivities are significantly lower, 11–24 % e.e. for cis cyclopropanes and 22–30 % e.e. for trans cyclopropanes, with the best results obtained with S-3-PhBox-Cu, and very close results with S-1-PhBox-Cu. With both catalysts, the obtained yield is comparable to that of the homogeneous catalyst. On the contrary the lowest enantioselectivities correspond to S-2-PhBox-Cu, the catalyst leading to the highest yield, even higher than the result in solution, which seems to indicate an important contribution of copper sites uncomplexed with the immobilized ligand.
When these results are compared with those obtained with indBox (Table 4), it can be seen that the rigid ligand leads to better results in enantioselectivity, 52–57 % e.e. for cis and 42–48 % e.e. for trans cyclopropanes. However, a deeper inspection of the results requires the calculation of the difference in the energy of the diastereomeric transition states (ΔE a ), as this is the parameter that controls the enantioselectivity. From the relative abundances of both enantiomers, it can be calculated that in the case of PhBox, the immobilization on S1 and S3 causes a decrease in that difference (ΔΔE a ) of around 0.4 kcal/mol in the cis and 0.45–0.5 kcal/mol in the trans cyclopropanes. However, from the results with indBox, immobilization induces a ΔΔE a of around 0.6 kcal/mol for cis and 0.9 kcal/mol for trans cyclopropanes, that is the effect of immobilization on the relative energy of the transition states is higher in the case of indBox.
On the contrary, the results of PhBox grafting on different solids using a unfunctionalized propyl linker described in the literature [13, 14] show that the enantioselectivity was not significantly modified with respect to the result in solution, indicating an important role of the linker in this effect. The presence of a linker functionalized with coordinating groups, and the possible restrictions in the conformational freedom of the ligand inside the mesopores, may induce different coordination modes (Fig. 3), including one mixed ligand-linker one, whose enantioselectivity would be lower than the typical chelate mode [37–39]. Thus unfunctionalized propyl linker seems to be more suitable for grafting on silica supports. However, recently it has been described the grafting of PhBox with this linker on several solid supports [18], including mesoporous silicas, and in most cases the results [40] are similar to those reported here and in only one case enantioselectivities are close to those obtained in solution.
After recycling, these chiral catalysts shows a drop in the enantioselectivities for both cis and trans cyclopropanes to values below 10 % e.e., but the yields are similar in S-1-PhBox-Cu and S-2-PhBox-Cu, whereas the reused S-3-PhBox-Cu is much less active for cyclopropanation. This effect had been also observed in the case of supported indBox [30], in spite of being the solid with the largest pores. The analysis of the recovered catalysts (Table 3) that Cu leaching is lower in the case of PhBox than in indBox, and even null in S-3-PhBox-Cu. This result demonstrates that leaching is not the main origin of the deactivation.
The N2 adsorption–desorption isotherms and the pore size distribution of the material S-2-PhBox-Cu before use and after the second run are given in Fig. 4. After use, the N2 isotherm is still of type IV but the hysteresis loop has changed from H1 to H3. This suggests the modification in the shape of the pores, from pores have regular dimensions not interconnected (H1 type), to slit-shaped pores (H3 type) [41, 42]. Also the pore size is reduced from 120 to 110 Å, with the appearance of smaller pores of about 33 Å. Besides, the surface area dropped from 372 to 281 m2/g, and the same trend was observed for the total pore volume, which was reduced from 0.86 to 0.79 cm3/g, although it does not present any microporosity. All these results demonstrate some blockage of the pores by organic groups, in agreement with the increase in carbon content (up to 2 mmol/g, Table 3). This must be due to the presence of products or by-products (diethyl fumarate and maleate from dimerization of diazoacetate, as well as oligomers), mainly on the copper sites, which has been proposed as the main deactivation mechanism in other supported box-Cu complexes [43].
Conclusions
A series of silica supported heterogeneous PhBox-Cu(II) catalysts have been successfully prepared by covalent immobilization on silica supports through carbamate linker. The results obtained in the cyclopropanation of styrene with ethyl diazoacetate have no apparent relationship with the textural properties of the solids. On the contrary, the drop in enantioselectivities with respect to the results in homogeneous phase parallels the behavior observed with a similar ligand indBox, and it seems to be related with the nature of the linker. The presence of coordinating functional groups in the linker, carbamate in this case, seems to be detrimental, probably in connection with a restricted conformational freedom that makes the formation of the expected chelate difficult. In contrast, the textural properties of the material do significantly affect the deactivation, mainly due to by-product adsorption.
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Acknowledgments
This work was made possible by the generous financial support from the Spanish Ministerio de Economía y Competitividad (Project CTQ2011-28124), the Diputación General de Aragón (E11 Group co-financed by the European Regional Development Funds) and the AECI (Agencia Española de Cooperación International project A/8491/07).
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Fakhfakh, F., Baraket, L., Ghorbel, A. et al. Catalytic activity of copper-bis(oxazoline) grafted on mesoporous silica in enantioselective cyclopropanation. Reac Kinet Mech Cat 116, 119–130 (2015). https://doi.org/10.1007/s11144-015-0872-x
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DOI: https://doi.org/10.1007/s11144-015-0872-x