In the identification of facial expressions related to certain emotions, certain parameters of event-related potentials (ERPs) can be interpreted as the respective indices. Patients with schizophrenia exhibit deficits in facial affect recognition at both behavioral and neural levels. We examined face expressionsensitive ERP components, N170 and N250, which are mostly related to encoding and decoding of the facial emotions, respectively, in 10 patients with schizophrenia and 10 healthy adults matched in age and gender. The mean amplitude and peak latency of the N170 and N250 waveforms, induced by visual stimuli in the form of happy, sad, fearful, and neutral face images, were measured and compared in these two groups. In the patient group, the mean amplitude of the N250 was higher in the right hemisphere (–1.402 mV on average) compared to that in the left hemisphere (–0.814 mV). The independent-sample t-test revealed that the N250 latencies were significantly longer in the patient group compared to those in the normal group for all four emotions. We, however, find no significant differences in the mean amplitude and peak latency of the N170 waveform between the two groups. Our study shows that decoding of the facial expressions in patients with schizophrenia is clearly impaired, which may contribute to cognitive and behavioral symptoms of the disease.
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References
J. D. Kropotov, Functional Neuromarkers for Psychiatry, San Diego (2016).
G. F. Woodman, “A brief introduction to the use of event-related potentials in studies of perception and attention,” Atten. Percept. Psychophysiol., 72, No. 8, 2031–2046 (2010).
R. L. Morrison, A. S. Bellack, and K. T. Mueser, “Deficits in facial-affect recognition and schizophrenia,” Schizophr. Bull., 14, No. 1, 67 (1988).
C. G. Kohler, T. H. Turner, W. B. Bilker, et al., “Facial emotion recognition in schizophrenia: intensity effects and error pattern,” Am. J. Psychiat., 160, No. 10, 1768–1774 (2003).
M. F. Green, “What are the functional consequences of neurocognitive deficits in schizophrenia?” Am. J. Psychiat., 153, No. 3, 321–330 (1996).
M. J. Sergi, Y. Rassovsky, K. H. Nuechterlein, and M. F. Green, “Social perception as a mediator of the influence of early visual processing on functional status in schizophrenia,” Am. J. Psychiat., 163, No. 3, 448–454 (2006).
G. Csukly, G. Stefanics, S. Komlósi, et al., “Eventrelated theta synchronization predicts deficit in facial affect recognition in schizophrenia,” J. Abnorm. Psychol., 123, No. 1, 178–189 (2014).
S. L. Kerr and J. M. Neale, “Emotion perception in schizophrenia: Specific deficit or further evidence of generalized poor performance?” J. Abnorm. Psychol., 102 No. 2, 312–318 (1993).
G. Sachs, D. Steger-Wuchse, I. Kryspin-Exner, et al., “Facial recognition deficits and cognition in schizophrenia,” Schizophr. Res., 68, No. 1, 27–35 (2004).
J. K. Wynn, J. Lee, W. P. Horan, and M. F. Green, “Using event related potentials to explore stages of facial affect recognition deficits in schizophrenia,” Schizophr. Bull., 34, No. 4, 679–687 (2008).
M. J. Herrmann, H. Ellgring, and A. J. Fallgatter, “Earlystage face processing dysfunction in patients with schizophrenia,” Am. J. Psychiat., 161, No. 5, 915–917 (2004).
P. J. Johnston, H. Devir, and F. Karayanidis, “Facial emotion processing in schizophrenia: No evidence for a deficit specific to negative emotions in a differential deficit design,” Psychiat. Res., 143, No. 1, 51–61 (2006).
F. Schneider, R. C. Gur, K. Koch, et al., “Impairment in the specificity of emotion processing in schizophrenia,” Am. J. Psychiat., 163, No. 3, 442–447 (2006).
V. C. Blau, U. Maurer, N. Tottenham, and B. D. McCand-liss, “The face-specific N170 component is modulated by emotional facial expression,” Behav. Brain Funct., 3 No. 1, 7 (2007).
B. I. Turetsky, C. G. Kohler, T. Indersmitten, et al., “Facial emotion recognition in schizophrenia: when and why does it go awry?” Schizophr. Res., 94, Nos. 1/3, 253–263 (2007).
C. A. Tamminga, “The neurobiology of cognition in schizophrenia,” J. Clin. Psychiat., 67, No. 9, e11 (2006).
D. Lundqvist, A. Flykt, and A. Öhman, The Karolinska Directed Emotional Faces – KDEF, CD ROM from Department of Clinical Neuroscience, Psychology section, Karolinska Institutet (1998).
A. Delorme and S. Makeig, “EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis,” J. Neurosci. Methods, 134, No. 1, 9–21 (2004).
A. M. Kring and O. Elis, “Emotion deficits in people with schizophrenia,” Annu. Rev. Clin. Psychol., 9, 409–433 (2013).
P. J. Johnston, W. Stojanov, H. Devir, and U. Schall, “Functional MRI of facial emotion recognition deficits in schizophrenia and their electrophysiological correlates,” Eur. J. Neurosci., 22, No. 5, 1221–1232 (2005).
M. Streit, A. Ioannides, T. Sinnemann, et al., “Disturbed facial affect recognition in patients with schizophrenia associated with hypoactivity in distributed brain regions: a magnetoencephalographic study,” Am. J. Psychiat., 158, No. 9, 1429–1436 (2001).
S. Campanella, C. Montedoro, E. Streel, et al., “Early visual components (P100, N170) are disrupted in chronic schizophrenic patients: an event-related potentials study,” Neurophysiol. Clin., 36, No. 2, 71–78 (2006).
S. Caharel, C. Bernard, F. Thibaut, et al., “The effects of familiarity and emotional expression on face processing examined by ERPs in patients with schizophrenia,” Schizophr. Res., 95, Nos. 1/3, 186–196 (2007).
J. Ramos-Loyo, A. A. González-Garrido, L. M. Sánchez- Loyo, et al., “Event-related potentials and eventrelated oscillations during identity and facial emotiona processing in schizophrenia,” Int. J. Psychophysiol., 71, No. 1, 84–90 (2009).
A. McCleery, J. Lee, A. Joshi, et al., “Meta-analysis of face processing event-related potentials in schizophrenia,” Biol. Psychiat., 77, No. 2, 116–126 (2015).
N. Frommann, S. Stroth, J. Brinkmeyer, et al., “Facial affect recognition performance and event-related potentials in violent and non-violent schizophrenia patients,” Neuropsychobiology, 68, No. 3, 139–145 (2013).
J. K. Wynn, C. Jahshan, L. L. Altshuler, et al., “Eventrelated potential examination of facial affect processing in bipolar disorder and schizophrenia,” Psychol. Med., 43, No. 1, 109–117 (2013).
D. I. Leitman, J. Loughead, D. H. Wolf, et al., “Abnormal superior temporal connectivity during fear perception in schizophrenia,” Schizophr. Bull., 34, No. 4, 673–678 (2008).
R. E. Gur, C. McGrath, R. M. Chan, et al., “An fMRI study of facial emotion processing in patients with schizophrenia,” Am. J. Psychiat., 159, No. 12, 1992–1999 (2002).
J. W. Tanaka, T. Curran, A. L. Porterfield, and D. Collins, “Activation of preexisting and acquired face representations: the N250 event-related potential as an index of face familiarity,” J. Cogn. Neurosci., 18, No. 9, 1488–1497 (2006).
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Sandhya, G., Prakash, H.P., Nayak, K.R. et al. Event-Related Potentials in Response to Facial Affect Recognition in Patients with Schizophrenia. Neurophysiology 51, 43–50 (2019). https://doi.org/10.1007/s11062-019-09789-6
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DOI: https://doi.org/10.1007/s11062-019-09789-6