We studied the mechanisms underlying impairment of conditioned food-procuring activity of rats in the state of long-term kindling induced by 120 injections of pentylenetetrazole (PTZ). In four animal groups, positive and negative modulation of the activity of the adrenergic and serotonergic neuromediatory systems was provided using introductions of ludiomil, α-methyl-para-tyrosine, L-tryptophan, or parachlorophenylalanine. Realization of the conditioned food-procuring reflex was estimated in the test with a radial labyrinth on the 30th, 60th, and 90th days. In the dynamics of PTZ-induced kindling, we observed intensification of cognitive dysfunctions, which was manifested in worsening of the results of training for the conditioned reflex. Similar effects, but of a significantly lower intensity, were found in kindling rats with activation of the noradrenergic and serotonergic systems. Therefore, the state of the above-mentioned systems is important for the development of cognitive dysfunctions under conditions of long-term PTZ-induced kindling.
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References
A. A. Shandra, L. S. Godlevskii, and A. I. Brusentsov, Kindling and Epileptic Activity [in Russian], AstroPrint, Odessa (1999).
R. Sankar and A. Mazarati, “Neurobiology of depression as a comorbidity of epilepsy,” in: Jasper’s Basic Mechanisms of the Epilepsies, J. L. Noebels, M. Avoli, and M. A. Rogawski, et al. (eds.), Natl. Center Biotechnol. Inform., Bethesda (2012), pp. 207–233.
R. Adamec, “Introduction to the special issue on kindling and behavior,” Neurosci. Biobehav. Rev., 24, No. 7, 687–689 (2000).
B. Vazquez and O. Devinsky, “Epilepsy and anxiety,” Epilepsy Behav., 4, Suppl., 20–25 (2003).
E. A. Prishchepa, “Changes in motor and research activities and emotional behavior of animals under conditions of longterm chemical kindling,” Visn. Psikhiat. Psikhofarmakoter., No. 2, 30–38 (2012).
O. O. Prishchepa, “Changes in swimming behavior of rats under conditions of long-term pentylenetetrazole kindling,” Odessa Med. Zh., No. 3, 13–17 (2013).
L. E. Kalynchuk, “Long-term amygdala kindling in rats as a model for the study of interictal emotionality in temporal lobe epilepsy,” Neurosci. Biobehav. Rev., 24, No. 7, 691–704 (2000).
M. G. Ezbekov, “Neurochemical aspects of interaction of monoaminergic and hormonal systems in pathogenesis of anxious depression,” Sotsial. Klin. Psikhiatr., 15, Issue 2, 108–110 (2005).
P. U. Bracs, D. M. Jackson, and P. Gregory, “Alphamethyl-p-tyrosine inhibition of a conditioned avoidance response: reversal by dopamine applied to the nucleus accumbens,” Psychopharmacology, 77, No. 2, 159–162 (1982).
I. A. Lapin, “Serotonin mechanisms of the action of antidepressants: positive and/or negative?” in: Antidepressants and Nootropics [in Russian], Nauka, Leningrad (1982), pp. 88–101.
A. V. Val’dman and Yu. A. Aleksandrovskii, Psychopharmacology of Neurotic Disorders: Experimental-and-Theoretical and Clinical-and-Pharmacological Analysis [in Russian], Meditsina, Moscow (1987).
J. Bureš, O. Burešova, and J. Hewstone, Technique and Basic Experiments for Studying the Brain and Behavior [Russian translation], Vysshaya Shkola, Moscow (1991).
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Prishchepa, O.O., Shandra, O.A. & Vast’yanov, R.S. Alterations in Conditioned Food-Procuring Activity Related to Long-Term Pentylenetetrazole Kindling in Rats. Neurophysiology 46, 452–454 (2014). https://doi.org/10.1007/s11062-015-9473-6
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DOI: https://doi.org/10.1007/s11062-015-9473-6