Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disorder characterized by the death of dopamine neurons, aggregation of α-synuclein, and severe motor impairment. This review examines current evidence on the key roles of neuroinflammation and immune dysfunction in neurodegeneration and development of the disease. Clinical and experimental evidence of microglial activation and the participation of Toll-like receptors, a wide range of chemokines, and pro- and anti-inflammatory cytokines in the dynamics of this disease is presented. Particular attention is paid to the roles of the innate and adaptive immune responses in the mechanisms of systemic inflammation in the brain and periphery. Brain-infiltrating immune cells and their subpopulations have been shown to be involved in neuroinflammation and neurodegeneration; changes in the composition and phenotype of peripheral immune cells and their functional characteristics have been demonstrated. Analysis of immune cell subsets and their ratios identifies fine PD-specific changes in cell populations which provide reliable biomarkers for diagnosis and prognosis of the course of the disease and for development of new approaches to anti-inflammatory and targeted therapy for PD.
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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 73, No. 4, pp. 454–478, July–August, 2023.
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Idova, G.V., Alperina, E.L. & Zhanaeva, S.Y. Neuroinflammation and Immune Dysfunction in the Mechanisms of Development of Parkinson’s Disease. Neurosci Behav Physi 53, 1534–1550 (2023). https://doi.org/10.1007/s11055-023-01549-8
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DOI: https://doi.org/10.1007/s11055-023-01549-8