Studies using presentation of visual stimuli in a “go/no go” scheme revealed differences in saccadic responses in healthy subjects and patients at ultra high risk of developing schizophrenia. Patients showed a greater number of erroneous responses to inhibitory stimuli and shorter latent periods (LP) for correct and erroneous saccades. Opposite asymmetries were demonstrated for the LP of saccadic responses in healthy subjects and patients: the LP of saccades to the right was shorter than to the left in healthy subjects, while the LP of saccades to the right was longer than to the left in patients. These data showed that impairments to the mechanisms controlling voluntary behavior occur at the pre-manifest stage of the course of schizophrenia when there is a ultra high risk of developing this condition. The results obtained here suggest that patients at ultra high risk of developing schizophrenia have impairments to the processes of voluntary and involuntary attention, as well as to the processes of inhibitory control, which may be due to dysfunction of the right prefrontal cortex and weakening of top down influences in the attention and inhibitory control systems.
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Becker, W. and Jurgens, R., “An analysis of the saccadic system by means of double step stimuli,” Vision Res., 19, No. 9, 967–974 (1979).
Benson, P. J., Beedy, S. A., Shphard, E., et al., “Simple viewing tests can detect eye movement abnormalities that distinguish schizophrenia cases from controls with exceptional accuracy,” Biol. Psychiatry, 72, 716–724 (2012).
Bragina, N. N. and Dobrokhotova, T. A., Functional Asymmetry in Humans, Meditsina, Moscow (1988).
Broerse, A., Crawford, T. J., and Boer, J. A., “Parsing cognition in schizophrenia using saccadic eye movements: a selective overview,” Neuropsychology, 39, 742–756 (2001).
Camchong, J., Dyckman, K. A., Austin, B. P., et al., “Common neural circuitry supporting volitional saccades and its disruption in schizophrenia patients and relatives,” Biol. Psychiatry, 64, No. 12, 1042–1050 (2008).
Coull, J. T., “Neural correlates of attention and arousal insights from electrophysiology, functional neuroimaging and psychopharmacology,” Prog. Neurobiol., 55, 343–361 (1998).
Eimer, M., Van Velzen, J., Cherry, E., and Press, C., “ERP correlates of shared control mechanisms involved in saccade preparation and in covert attention,” Brain Res., 1135, 134–166 (2007).
Everling, S. and Fischer, B., “The antisaccade: a review of basic research and clinical studies,” Neuropsychology, 36. No. 9, 885–892 (1998).
Gaymard, B., Ploner, C. J., Rivaud, S., et al., “Cortical control of saccades,” Exp. Brain Res., 123, 159–163. (1998).
Goldman-Rakic, P. S., “Topography of cognition: Parallel distributed networks in primate association cortex,” Ann. Rev. Neurosci., 11, 137–156 (1988).
Hughes, M. E., Fulhamm W. R., Johnston, P. J., and Michie, P. T., “Stop-signal response inhibition in schizophrenia: behavioural, event-related potential and functional neuroimaging data,” Biol. Psychol., No. 1, 220–231 (2012).
Kable, J. and Glimcher, P., “The neurobiology of decision: consensus and controversy,” Neuron, 63, 733–745 (2009).
Klein, C., Rockstroh, B., Cohen, R., and Berg, P., “Contingent negative variation (CNV) and determinants of the post-imperative negative variation (PINV) in shizophrenic patients and healthy controls,” Schizophr. Res., 21, 97–110 (1996).
Lijffijt, M., Lane, S. D., Maier, S. L., et al., “P50, N100 and P200 sensory gating: Relationships with behavioral inhibition, attention, and working memory,” Psychophysiology, 46, No. 5, 1059–1072 (2009).
Lisberger, S., Fuch, A., King, W., and Evinger, L., “Effect of mean reaction time on saccadic responses to two step stimuli with horizontal and vertical components,” Vision Res., 15, 1021–1029 (1975).
Maruff, P. and Hay, D., “Asymmetries of the covert orienting of visual spatial attention in schizophrenia,” Neurophysiology, 33, No. 10, 1205–1223 (1995).
Moran, M. J. and Thaker, G. K., “Covert visual attention in schizophrenia spectrum personality disorder subjects: visuospatial cuing and alerting effects.” J. Psychiatr. Res., 30, No. 4, 261–275 (1996).
Nestor, P. G., Faux, S. F., McCarley, et al., “Attention cues in chronic schizophrenia. Abnormal disengagement of attention.” J. Abnorm. Psychol., 101, 682–689 (1992).
Nieman, D., Becker, H., van de Fliert, R., et al., “Antisaccade task performance in patients at ultra high risk for developing psychosis,” Schizophr Res., 95, No. 1–3, 54–60 (2007).
Omel’chenko, M. A., Rumyantsev, A. O., and Kaleda, V. G., “Dynamics of psychopathological symptoms of ultra high risk of manifesting schizophrenia in patients with nonpsychotic mental disorders at juvenile age,” Zh. Nevrol. Psikhiat., 116, No. 2, 16–21 (2016).
Posner, M., “Orienting of attention,” J. Exp. Psychol., 32, 3–21 (1980).
Ptak, R., Camen, C., Morand, S., and Schnider, A., “Early event-related cortical activity originating in the frontal eye fields and inferior parietal lobe predicts the occurrence of correct and error saccades,” Hum. Brain Mapp., 32, No. 3, 358–69 (2011).
Reuter, B., Moellers, D., Bender, J., et al., “Volitional saccades and attentional mechanisms in schizophrenia patients and healthy control subjects,” Psychophysiology, 48, No. 10, 1333–1339 (2011).
Shul’govskii, V. V., Slavutskaya, M. V., Lebedeva, I. S., et al., “Characteristics of saccadic reactions to sequential visual stimuli in health and schizophrenia,” Fiziol. Cheloveka, 41, No. 4, 37–43 (2015).
Slavutskaya, M. V., Shukeir, Z, and Shul’govskii, V. V., “Latent periods of saccadic eye movements in humans in different visual stimulation conditions,” Zh. Vyssh. Nerv. Deyat., 58, No. 2, 133–152 (2008).
Slavutskaya, M. V. and Shulgovskiy, V. V., “Presaccadic brain Potentials in conditions of covert attention orienting.,” Span. J. Physiol., 10, No. 2, 277–284 (2007).
Spencer, K. M., Nestor, P. G., Valdman, O., et al., “Enhanced facilitation of spatial attention in schizophrenia,” Neuropsychology, 25, No. 1, 76–85 (2011).
Strelets, V. B., Garakh, Zh. V., Mar’ina, I. V., et al., “Time characteristics of the initial stage of processing verbal information in health and schizophrenia,” Zh. Vyssh. Nerv. Deyat., 62, No. 2, 165–173 (2012).
Thakkar, K. N., Schall J. D., Boucher, L., et al., “Response inhibition and response monitoring in a saccadic countermanding task in schizophrenia,” Biol. Psychiatry, 69, No. 1, 55–62 (2011).
Thakkar, K. N., Schall, J. D., Heckers, S. and Park, S., “Disrupted saccadic corollary discharge in schizophrenia,” J. Neurosci., 35, No. 27, 9935–9947 (2015).
Urbakh, V. Yu., Biometric Methods, Nauka, Moscow (1964).
Van Tricht, M. J., Nieman, D. H., Bourée, T., et al., “Increased saccadic rate during smooth pursuit eye movements in patients at ultra high risk for developing a psychosis,” Brain Cogn., 73, No. 3, 215–221 (2010).
Yung, A. R., Yuen, H. P., Berger, G., et al., “Declining transition rate in ultra high risk (prodromal) services: Dilution or reduction of risk?” Schizophr. Bull., 33, 673–681 (2007).
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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 66, No. 6, pp. 682–689, November–December, 2016.
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Slavutskaya, M.V., Lebedeva, I.S., Karelin, S.A. et al. Characteristics of Saccadic Responses in an Experimental “Go/No Go” Scheme in Healthy Subjects and Those at Ultra High Risk of Developing Schizophrenia. Neurosci Behav Physi 48, 261–266 (2018). https://doi.org/10.1007/s11055-018-0559-7
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DOI: https://doi.org/10.1007/s11055-018-0559-7