Catalepsy is a passive defensive freezing reaction in response to threatening stimuli. In hypertrophied form it constitutes a symptom of impaired brain function. In mice, the main gene determining the predisposition to catalepsy is located in the distal 111.35–116.16 Mbp fragment of chromosome 13. This fragment was transferred by backcrossing from the genome of cataleptic CBS mice to the genome of the catalepsy- resistant strain C57BL/6J and two recombinant strains were obtained – C57BL6.CBA-D13Mit76C and C57BL6.CBA-D13Mit76B – carrying this fragment from CBA or C57BL/6J, respectively. The proportion of cataleptic animals among C57BL6.CBA-D13Mit76C mice was found to be greater than that among control C57BL6.CBA-D13Mit76B mice. Testing in the startle reaction and a social interaction paradigm revealed no differences in behavior. At the same time, C57BL6.CBA-D13Mit76C mice showed lower levels of exploratory activity in the open field test than C57BL6.CBA-D13Mit76B mice. The duration of immobility in C57BL6.CBA-D13Mit76C animals in the forced swimming test was also significantly shorter than that in C57BL6.CBA-D13Mit76B mice.
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 101, No. 6, pp. 670–677, June, 2015.
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Kondaurova, E.M., Bazovkina, D.V. & Kulikov, A.V. Studies of Catalepsy and Other Forms of Behavior Using Recombinant Mouse Strains. Neurosci Behav Physi 46, 992–996 (2016). https://doi.org/10.1007/s11055-016-0343-5
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DOI: https://doi.org/10.1007/s11055-016-0343-5