Abstract
Within the last two decades, plant viral vectors have emerged as an excellent tool for the expression of foreign peptides and proteins. Virus particles carrying foreign antigenic epitopes present some interesting advantages for vaccine design and other applications. This review covers recent advances in the use of some typical plant viruses with helical particles that present heterologous peptides with particular emphasis on particles derived from the Potato virus X (PVX) and its uses.
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Abbreviations
- aa:
-
amino acid
- AlMV:
-
Alfalfa mosaic virus
- CP:
-
coat protein
- CPMV:
-
Cowpea mosaic virus
- GFP:
-
green fluorescent protein
- GUS:
-
β-glucuronidase
- HC-Pro:
-
helper component proteinase
- HPV:
-
Human papillomavirus
- HR:
-
hypersensitive response
- mAbs:
-
monoclonal antibodies
- MP:
-
movement protein
- ORF:
-
open reading frame
- PPV:
-
Plum pox virus
- PVA:
-
Potato virus A
- PVX:
-
Potato virus X
- PVY:
-
Potato virus Y
- RdRp:
-
viral replicase
- ssRNA:
-
single stranded RNA
- TMV:
-
Tobacco mosaic virus
- TRV:
-
Tobacco rattle virus
- TSP:
-
total soluble protein
- TuMV:
-
Turnip mosaic virus
- VLP:
-
virus like particles
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Acknowledgements: This research was supported by the Grant Nos. GA15-10768S and P501/12/1761 of the Czech Science Foundation, CZ.2. 16/3.1.00/24014 from the European Regional Development Fund, Operational Programme Prague-Competitiveness.
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Plchova, H., Cerovska, N., Vaculik, P. et al. Plant viruses as scaffolds for the presentation of vaccine epitopes. Biol Plant 61, 1–12 (2017). https://doi.org/10.1007/s10535-016-0690-7
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DOI: https://doi.org/10.1007/s10535-016-0690-7